ADHD and autism (ASD) pathways (Homo sapiens)

From WikiPathways

Revision as of 02:56, 5 January 2024 by Alexmadsen1 (Talk | contribs)
Jump to: navigation, search
766814113659, 1841129314114142119112, 144MitochondriaNucleusSynapticVesicleSynapticVesicleAdrenal VesicleAdrenal MedullaRTKmethionine synthase interactomeCytoskeletalOrganizaitonRegulation of actin cytoskeletonLegendDisks large homologNote: enzymes color coded for readability exogenous cannabinoidIntestinCatecholamineSynthesisROSReactive OxygenStressFolateCycleSerotoninSynthesis(5-HT)Kynurenine Pathway (KP)MelatoninSynthesisAlex Madsen2023copyright (c) 2023CC0 1.0 Universal (CC0 1.0)Public Domain DedicationSynaptophysinSynaptobrevinComplexSynaptic Cleftcytosol (intracellular)MethionineCyclen.e.BH4SynthaseOpioid Receptorhydroxylation101Endocannabinoid System (ECS)IntercellularEGFRSSRIs(fluoxetine, citalopram,sertraline, paroxetine,escitalopram)SNPsingle nucleotidepolymorphismTBCD7glycineProteinMetaboliteGATMGeneProductSCN2ARHOANMPEAPLCG1MAPK1guanidinoacetateINSRRHEBCALM3KITphenylethylamine2-phenylethylaminePEAcreatinePDGFRA2-phenylacetaldehydeDAGL-ornithineDRD4 VNTR exon III-7r4747474764, 861694771, 94, 98rs6189140MN2+CNTN6rs11370709, 30, 39, 73, 79...NA AldehydeTHF-polyglutamate3-MT SOSCN1Ars6561333148Imidazole-4-acetate72, 107a 1-(1-hydroxyalkyl)-sn-glycerol92FMN74rs434357ALDH2107rs12843533178rs237897NOX4H2O2rs1051312140SCN4BDHMA1-O-(1,2-saturated-alkyl)-sn-glycerol92ADAM10160rs628057q-BH21, 23HNMTrs799701257, 97GABRA2ACE136angiotensin I136SAMSAMe31rs1487275148PCBD11rs10879352148HCFC1 (cblX)124, 127, 184PCBD21L-tryptophan27, 112SLC25A32AANAT17, 60, 80, 112SCN5Ars11178997140MAOAALDHserine11TYrs602618128NMN-SOCSADPPH455serotonin112rs10521432120PTS55sepiapterin14rs1923886148MG2+NormetanephrineNMGABRB3rs205620238, 131rs686148THF11rs59896816, 32NOformate11MAOBL-citrulliners1950902153rs146510773FADCBSGABRA3Metanephriners378514356, 91rs74060154tyraminers207101061, 75GABRA5SLC18A148, 57rs1023159rs165774GLS151SLC46A1CNTN1B6pyridoxineCPLX1PDXKglycine betaineFOLH1110SHMT2taurine5-MTHFMOPGALAdoCblMeCbl(III)alaminOPRM137deamido-NAD+122CYP2D6L-histidinol72SCN10ACNTNAP4SLC17A6rs1406946148ALDH5A1DHNTP55, 87DAG1L-cysteatemelatonin112, 144rs3622043-MTSULT1A3rs224244633, 106, 158rs229844453, 75GCATglycine11SLC25A12rs35062132rs29349661485-10MeTHF10-formyl-THF11MTRRO2−76DOPL78rs3601790, 157PNPO5, 10-MTHFPG11SCN7AHISN84-aminobutanoateNADSYN1122AHCYL1rs2236225153rs237889rs590551120rs1284326851rs1697635857L-tyrosiners594902881MTHFD2LMN-SO4nicotinate D-ribonucleotide(2−)4N-METHYL-HISTAMINE102, 121B9rs3027407161, 178SLC17A8RFK74dopamineDBHAOC1SIRT3112, 144cysteine sulfinateSAH31L-dopaNM Aldehyde pyridoxine 5'-phosphaters651646 19rs227063757S-adenosyl-L-homocysteineMHPGMOPEGrs413004757DOPET78rs4818FLAD1Biopterinrs3782025148histamine72, 121GABRA11′-OXPH426, 55SCN8ASLC19A1NOS1rs139093857, 126, 145PNMTrs179983628, 57, 120, 154rs632382GABRA4rs6582071148rs227970957AKR1B155rs626785BHMT146DHFR55, 87ALDH9A1rs227064157H4gtpGPTrs373389029, 137HDCN-Methylhistamine102, 121imidazole-4-acetaldehyde107, 121pyridoxaminers165599GABRB1QPRT122FAAH2rs5906883 161, 178SOD2112, 144rs737865rs1801198148rs665180644, 120, 154CNTNAP242rs5905512154SCN2BSCN9Aq-H2BPT5, 92GABRG1SLC6A457NAS112L-alanine5-MTFe2+rs17469654GABRG2ADGRL3GPCRsrs2268491rs1667627rs1672717148rs7632287glycerolO2L-histidine72DOPAC35, 78rs265981GABRQfatty aldehydes88DHPGrs1800544128, 140Alpha-dystroglycan125hemiacetals88SCN3BNOX1CNTN2TDCCNTNAP1GABRB2alkylglycerols88Xanthurenic acid27rs1051266SLC6A2134GCH155, 87rs59444557rs2838684052, 1682-oxoglutarateMet31rs468054, 85rs229281338, 131rs381303457rs197927775, 145, 149, 170CBCollybistin125, 174SLC52A2FOLR1noladin ether5, 36, 113, 175rs208810254MTHFD2SLC6A3STXBP1rs3746544140QDPR1TAAR145, 114rs3785157168TYMS173SCN1Bpyridoxalrs556933NOX3DNMT1TCN2CNTN5rs77986757, 135rs53576acetateSLC52A1rs180508757, 149AGTR1rs4633NOS3SCN4AMOCOSPAHGABRDrs6269DHFAGMO5, 92MoCoL-glutamine15, 151rs151257822rs237902rs429157ASMT80, 112(4aS,6R)-4a-hydroxy - BH423rs25191566Derived From WP4159GABA receptor signaling5-HialDDCmoco sulfide rs674603034, 85HVAL35SOD195NCAM142RIT2155TPH223glycerol 3-phosphateMTR31SLC52A3Derived From WP4271Vitamin B12 disordersrs4570625140Pharmacological Intervention(drug)Angiotensinogen136CNTN4MTHFRrs631857hypotaurineNMNAT1122DOPGALSCN11ASLC25A13ALDH1L1rs237887B231, 74rs453257SCN3Ars1352250148rs4570625140GPHN125, 174OH-NOX5rs302740073rs2129575170CDO1SLC17A7KYAT3ALDH1L2GKSYPFMO1REN136rs271010257CTH6R-BH492adrenalineAKRAHCYCNTN3arachidonic acidcystathionineDOPEGSPR55, 875-hydroxy-L-tryptophan112CNTNAP3rs779474557rs179997120, 37, 85L-arginine47TPH123GLUL49rs2254298ADHL-cysteiners444690932L-phenylalanine2′-OXPH426, 55homocysteine31MAT1AMAT2BBH423BH27,8-dihydrofolate23AKR1A1AKR1C355CBR155AKR1C1B95, 10-MTHFPG11SHMT110-formyl-THF11MTHFD1MTHFD1LTHF11NADPrs87665742122NOS2NADPNADPHONOO-serotoninDopamineReceptorsDRD3DRD5DRD4DRD2DRD1HTR4HTR5bHTR6HTR1D133HTR1EHTR7HTR2AHTR1FHTR5aHTR2BHTR1A133HTR1B133HTR2CADRA2CADRA1AADRB3aADRA1BADRA2AADRB1ADRA2BADRA1DADRB2AdrenergicReceptorsserotoninnorepinephrinedopaminers180113157, 111rs180113357, 111rs4846049111rs1801394132rs1532268rs3819331rs2518352rs121913223rs70991108norepinephriners1677712dopamineserotonindopamineVMAHVA35, 78COMT785-HIAAnorepinephrineadrenalineClonidine162Guanfacine162Prazosin77L-glutamateL-AspL-Asprs908670131Ca2+SNAP25VAMP2SYT1STX1ACa2+GlutReceptAMPAAMPARPSDGlutamatereceptorionotropicNMDANMDARMetabotropicglutamatereceptormGluGRM8KCNA2KCNA1DLG3GRM6GRM5GRM3KCNA3GRIN2CDLG5DLGAP5125GRM4GRIN2BDLGAP3125GRIA183GRIN1GRM2GRIN2ADLGAP4125KCNA4KCNA5DLG2KCNA6GRIA2GRM7DLGAP2125OXTR42MC4R42SHANK168GRIA483F-actin141NLGN1125S-SCAM141NRXN2125GRIN3BABL1141HOMER2141CTNNB1GRIN3ASHANK141DLG4141SAPAP141NLGN2125DLGAP1125KCNA7HOMER141CBL141SRBS221Cortactin141GRIN2DNLGN4X125NRXN3125APP141SHANK38, 42GRIA3GRIP2HOMER3141DLG1NRXN1125NLGN342, 125, 165PTK2B141P141HOMER1141SHANK268GRM1GRIP1CACNG2141PSD9596, 125, 159, 182CTTN141F-actin141SAPAP141SHANK141Cortactin141F-actin141F-actin141SHANK141SAPAP141Cortactin141PSD9596, 125, 159, 182ABL2141SHANK141SAPAP141HOMER141PSD9596, 125, 159, 182GKAP1141P141P141S-SCAM125, 141Beta-dystroglycan125Potassium(k)channelPresynapticPostsynapticGABReceptors5-MTHFFOLR2HTR3AHTR3BHTR3CHTR3DHTR3Ers1543334183CACNG6CACNG7CACNG3CACNG4CACNG8CACNG5CACNG1GNAQ50PLCB50oxytocinOXTCACNA1C50angiotensin II136SOD295SOD395NADPHMAO InhibitorsMAOIsB95-MTHF5-10MeTHFrs6198140rs629614018118118118162, 1816262626262, 181626262, 181626262, 18162181Glucocorticoid stimuliPro-inflammatorycytokines3-Hydroxykynurenine13, 27Kynurenic Acid27Picolinic Acid13IFNGKYNU3-Hydroxyanthranilic Acid4, 13, 27KAT1Quinolinic AcidQUIN4, 27, 76, 122Anthranilic Acid13, 27Kynurenine4, 13, 27NAD+122INFAKMOIDO1IDO2T23OKAT3AADATAATMTNFAQUINNitric Oxide (NO) SynthaseSynaptic CleftSynaptic CleftadrenalineNorepinephrineNAAdrenaline Synaptic VesicleadrenalineNeurotransmitter Catabolism (Breakdown)GABA Synaptic vesiclegamma-hydroxybutyrate L-glutamate15, 151GABAGABBR1SLC32A1succinate citrate cycleGAD2succinic semialdehydeALDH9A1ABATGAD1GABASLC6A1GABAGLS21512A-3OBUL-threonineFMO3HistamineSynthase &CatabolismCysteine Synthase &CatabolismPLPpyridoxal 5'-phosphateFADFADB2riboflavin31, 74PLPPLPPLPFMN74Lysosome69130171147cblJABCD4184, 185Succinyl-CoAMMUTCbl185CD320R-cob(III)alamin185cob(II)alamin185143cob(I)alamincbLAMMAAMethylmalonyl-CoAMMADHC184cblFLMBRD1184cbLCMMACHC184, 185cbLCMMACHC184, 185FADFMN130MMABcblBPLPPLPPLPPLPPLPPLPR-cob(III)alamin185CblD-1MMADHC184, 185CblD-2MMADHC184, 185CblDMMADHC184, 185CYP3A4CYP2C1918endogenous cannabinoidsPKACBD catabolismNeuronal cell of CNS(hyppocampus, cerebellum or basal ganglia)ADCY1CNR140, 113CYP2C911-OH-THCMAPK PhosphatidylethanolamineDAGLBcAMP NAPEPLD156ADCY73NAPEDAGLA156Arachidonic acidTHC1''-hydroxycannabidiol182-AG167FAAH156L-glutamate138ADORA2A16CNR2Ca2+ATPAEAAnti-inflammatory pathwaysCOOH-THC117CBD1762''-hydroxycannabidiol 183''-hydroxycannabidiol 184''-hydroxycannabidiol 185''-hydroxycannabidiol 186a-hydroxycannabidiol 186b-hydroxycannabidiol 187-hydroxycannabidiol 18endogeneous cannabinoid synthesisPRKACBPRKACAPRKAR1APRKAR2BPRKAR1BPRKACGPRKAR2ACa2+CBDKUVAN(BH4 Supplement) 77Derived From WP3869Cannabinoid receptor signalingCatabolism(Vitamin B12)pathwayPLPPLPGlutamate Synaptic VesicleL-glutamate151adrenalineDextroamphetamine + Amphetamine (Adderall)Viloxazine(Qelbree)63rs255093657rs13189021Ketamine 14843, 46AEASNRIs(Desvenlafaxine, Duloxetine,Levomilnacipran, MilnacipranVenlafaxine)COMT Inhibitors84NRIs(Atomoxetine /Strattera,Reboxetine /Edronax & Vestra)Methylphenidate(Ritalin)2-AG12, 77PLP167SAMSAMe31SAH31SAMeSAH31NDRIBupropion (Wellbutrin)3112, 77SAMeSAH3131SAMeSAH3131RisperidoneSerotoninReceptors77rs916455129rs1800955109CalciumchannelsPIK3AP1TSC18664, 86AKT164, 86PTEN86PIP264, 86PIP3AKT264, 86AKT364, 86TSC264, 8664, 86MTORPIK3R2 PIK3CB PIK3CA PIK3R1 PIK3CDPIK3R3PDGFRBPRKCD PRKCZ PRKCA 179PRKCB PLCG2PRKCG mTORC1mTORC1 complexMLST8mTORC2 complexAKT1S1RPTORDEPTORMTORMLST8MAPKAP1RICTORMTORMAPK3SAMeSAH31MeCbl(III)alamin31cob(II)alamincbLCMMACHC184, 185FAD


Description

Pathways associated with ADHD (attention deficit hyperactivity disorder) and autism spectrum disorder (ASD). Neurodivergent conditions linked in studies to these pathways include ADHD, autism, dyspraxia, dyslexia, dyscalculia, bipolar disorder, obsessive-compulsive disorder, sensory processing disorders, and Tourette syndrome. This aims to be a highly detailed, comprehensive map of the metabolic pathways associated with these disorders, from indicated input vitamins through synthesis to signaling across the synaptic gap, re-uptake, and catabolism receptors. This pathway is constructed with computational analysis and machine learning in mind. In cases where there is a trade-off between readability and parametric accuracy, parametric accuracy is prioritized. This pathway is inspired by Kimberly Kitzerow and her meta-analysis research on the biomechanisms and pathways behind invisible illnesses.

https://kimberly102347.com/the-chart/

Pathways included in this map: One-Carbon (1C), Metabolism Folate Cycle, Methionine Cycle, Tetrahydrobiopterin (BH4) Pathway, Neurotransmitter Synthesis, Reuptake, and Breakdown, Kynurenine Pathway (KP), Endocannabinoid System (ECS), Neuroreceptor Dynamics in the Synaptic Cleft,

ROS Reactive Oxygen Stress.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. https://magazine.medlineplus.gov/pdf/Common-antidepressants.PDF_.Final_.09012023.pdf; ''''; ,
  2. Yip CK, Murata K, Walz T, Sabatini DM, Kang SA; ''Structure of the human mTOR complex I and its implications for rapamycin inhibition.''; Mol Cell, 2010 PubMed Europe PMC Scholia
  3. DOI: 10.1093/nar/gkab1016 RHEA:15889 RHEA:36683; ''''; , DOI Scholia
  4. 10.1097/YPG.0000000000000010; ''''; , DOI Scholia
  5. DOI: 10.3390/ijms19082439; ''''; , DOI Scholia
  6. Gerber SH, Südhof TC.; ''Molecular determinants of regulated exocytosis.''; PubMed Europe PMC Scholia
  7. DOI: 10.3390/nu13093207; ''''; , DOI Scholia
  8. Huang J, Manning BD; ''The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.''; Biochem J, 2008 PubMed Europe PMC Scholia
  9. DOI: 10.1101/cshperspect.a036780; ''''; , DOI Scholia
  10. Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U, Wollheim CB.; ''Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits.''; PubMed Europe PMC Scholia
  11. https://www.pharmgkb.org/pathway/PA166181140; ''''; ,
  12. DOI: 10.1016/j.gene.2017.05.003; ''''; , DOI Scholia
  13. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  14. ''Assessment of Methylphenidate and Propranolol Combination Treatment in Comparison with Methylphenidate and Placebo Among Children with Attention Deficit Hyperactivity Disorder (ADHD)''; Scientific Medical Journal, 2011
  15. DOI: 10.3390/genes12091407; ''''; , DOI Scholia
  16. Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbe S, Clague MJ, Tooze SA; ''Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.''; Autophagy, 2010 PubMed Europe PMC Scholia
  17. DOI: 10.1176/appi.ajp.161.4.662; ''Circadian variations of hormonal content in the nervous system of the crayfish.''; Comp Biochem Physiol A Comp Physiol, 1975 DOI Scholia
  18. https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''''; ,
  19. DOI: 10.1186/s12993-015-0080-x; ''''; , DOI Scholia
  20. DOI 10.3390/nu8020068; ''''; , DOI Scholia
  21. https://www.genome.jp/pathway/map04921+K04229; ''''; ,
  22. https://www.pharmgkb.org/pathway/PA166181002; ''''; ,
  23. Cochrane, L., Conroy, Judith, Tansey, Katherine, Gill, Michael, Anney, R., Gallagher, Louise, https://imfar.confex.com/imfar/2008/webprogram/Paper2290.html; ''Genes Analysed for Association with Autism and DBH Level''; Conference: International Meeting for Autism Research 2008, 2008/05/16
  24. doi: 10.1080/10409238.2021.1979459; ''''; , DOI Scholia
  25. DOI: 10.1038/ng1136; ''''; , DOI Scholia
  26. ; ''''; http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNR2&keywords=cnr2,
  27. 10.1161/hc3801.095585; ''''; , DOI Scholia
  28. https://psychscenehub.com/psychinsights/guanfacine-and-clonidine-for-adhd/; ''''; ,
  29. DOI: 10.1016/j.pnpbp.2018.01.016; ''''; , DOI Scholia
  30. Olson CO, Pejhan S, Kroft D, Sheikholeslami K, Fuss D, Buist M, Ali Sher A, Del Bigio MR, Sztainberg Y, Siu VM, Ang LC, Sabourin-Felix M, Moss T, Rastegar M; ''MECP2 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients.''; Front Genet, 2018 PubMed Europe PMC Scholia
  31. Lawler NG, Gray N, Kimhofer T, Boughton B, Gay M, Yang R, Morillon AC, Chin ST, Ryan M, Begum S, Bong SH, Coudert JD, Edgar D, Raby E, Pettersson S, Richards T, Holmes E, Whiley L, Nicholson JK; ''Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.''; J Proteome Res, 2021 PubMed Europe PMC Scholia
  32. DOI: 10.3389/fnmol.2022.922840; ''''; , DOI Scholia
  33. DOI: 10.1038/s41398-020-0755-4; ''''; , DOI Scholia
  34. Su, H, Lenardo, M.; ''Chapter 5 Combined Immune Deficiencies''; https://doi.org/10.1016/B978-0-12-405546-9.00005-4, 2014 DOI Scholia
  35. DOI: 10.1093/ijnp/pyw013; ''''; , DOI Scholia
  36. DOI: 10.1186/2040-2392-3-10; ''''; , DOI Scholia
  37. Catena V, Fanciulli M; ''Deptor: not only a mTOR inhibitor.''; J Exp Clin Cancer Res, 2017 PubMed Europe PMC Scholia
  38. DOI: 10.1161/01.ATV.0000243924.00970.cb; ''''; , DOI Scholia
  39. DOI: 10.1186/2040-2392-2-8; ''''; , DOI Scholia
  40. Yang SN, Berggren PO.; ''Beta-cell CaV channel regulation in physiology and pathophysiology.''; PubMed Europe PMC Scholia
  41. Liu M, Wang X, Wang L, Ma X, Gong Z, Zhang S, Li Y; ''Targeting the IDO1 pathway in cancer: from bench to bedside.''; J Hematol Oncol, 2018 PubMed Europe PMC Scholia
  42. 10.3109/08039488.2015.1089321; ''''; , DOI Scholia
  43. DOI: 10.1016/j.biopha.2020.110496; ''''; , DOI Scholia
  44. Jung CH, Ro SH, Cao J, Otto NM, Kim DH; ''mTOR regulation of autophagy.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  45. DOI: 10.1038/s41430-022-01110-9.; ''''; , DOI Scholia
  46. Zhao Y, Fang Q, Straub SG, Sharp GW.; ''Both G i and G o heterotrimeric G proteins are required to exert the full effect of norepinephrine on the beta-cell K ATP channel.''; PubMed Europe PMC Scholia
  47. doi: 10.1159/000142363; ''''; , DOI Scholia
  48. DOI: 10.1038/s41531-021-00161-2; ''''; , DOI Scholia
  49. DOI: 10.1186/1471-2105-9-S12-S23; ''''; , DOI Scholia
  50. DOI: 10.1016/j.cell.2010.05.024; ''''; , DOI Scholia
  51. https://www.omim.org/entry/612100; ''''; ,
  52. DOI: 10.1111/cge.13243; ''''; , DOI Scholia
  53. DOI: 10.1038/nn.4352; ''''; , DOI Scholia
  54. DOI: 10.3389/fphar.2021.740996; ''''; , DOI Scholia
  55. doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  56. Yajima H, Komatsu M, Sato Y, Yamada S, Yamauchi K, Sharp GW, Aizawa T, Hashizume K.; ''Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase.''; , PubMed Europe PMC Scholia
  57. Raux E, Schubert HL, Warren MJ; ''Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.''; Cell Mol Life Sci, 2000 PubMed Europe PMC Scholia
  58. 10.1371/journal.pone.0053727; ''''; , DOI Scholia
  59. DOI: https://doi.org/10.3390/children10101639; ''''; , DOI Scholia
  60. https://hmdb.ca/proteins/HMDBP00295; ''''; ,
  61. DOI: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  62. doi: 10.1073/pnas.1002404107; ''''; , DOI Scholia
  63. Vignali S, Leiss V, Karl R, Hofmann F, Welling A.; ''Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.''; PubMed Europe PMC Scholia
  64. doi: 10.1002/jimd.12060; ''''; , DOI Scholia
  65. Lang J.; ''Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.''; PubMed Europe PMC Scholia
  66. Anderson GD, Chan LN; ''Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products.''; Clin Pharmacokinet, 2016 PubMed Europe PMC Scholia
  67. MacDonald PE, Wang G, Tsuk S, Dodo C, Kang Y, Tang L, Wheeler MB, Cattral MS, Lakey JR, Salapatek AM, Lotan I, Gaisano HY.; ''Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.''; PubMed Europe PMC Scholia
  68. Carrier EJ, Auchampach JA, Hillard CJ; ''Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression.''; Proc Natl Acad Sci U S A, 2006 PubMed Europe PMC Scholia
  69. http://autism.mindspec.org/GeneDetail/NLGN4X; ''''; ,
  70. DOI: 10.3389/fpsyt.2021.788779; ''''; , DOI Scholia
  71. Ross D, Joyner WL.; ''Resting distribution and stimulated translocation of protein kinase C isoforms alpha, epsilon and zeta in response to bradykinin and TNF in human endothelial cells.''; PubMed Europe PMC Scholia
  72. Grabsch H, Pereverzev A, Weiergräber M, Schramm M, Henry M, Vajna R, Beattie RE, Volsen SG, Klöckner U, Hescheler J, Schneider T.; ''Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system.''; PubMed Europe PMC Scholia
  73. DOI: 10.1186/s40246-021-00319-2; ''''; , DOI Scholia
  74. DOI: 10.1016/j.neures.2008.11.007; ''''; , DOI Scholia
  75. DOI: https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  76. Bratanova-Tochkova TK, Cheng H, Daniel S, Gunawardana S, Liu YJ, Mulvaney-Musa J, Schermerhorn T, Straub SG, Yajima H, Sharp GW.; ''Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.''; PubMed Europe PMC Scholia
  77. DOI: 10.3389/fphar.2018.00279; ''''; , DOI Scholia
  78. Froese DS, Gravel RA; ''Genetic disorders of vitamin B12 metabolism: eight complementation groups--eight genes.''; Expert Rev Mol Med, 2010 PubMed Europe PMC Scholia
  79. DOI: 10.1038/mp.2013.140; ''''; , DOI Scholia
  80. 10.1038/sj.mp.4002016; ''''; , DOI Scholia
  81. DOI: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  82. doi: 10.1007/s13311-021-01043-4; ''''; , DOI Scholia
  83. Watkins D, Rosenblatt DS; ''Inborn errors of cobalamin absorption and metabolism.''; Am J Med Genet C Semin Med Genet, 2011 PubMed Europe PMC Scholia
  84. ''''; , PubMed Europe PMC Scholia
  85. https://my.clevelandclinic.org/health/treatments/24797-snri; ''''; ,
  86. DOI: 10.3389/fphar.2019.00452; ''''; , DOI Scholia
  87. Roach PJ; ''AMPK -> ULK1 -> autophagy.''; Mol Cell Biol, 2011 PubMed Europe PMC Scholia
  88. Cheng H, Straub SG, Sharp GW.; ''Protein acylation in the inhibition of insulin secretion by norepinephrine, somatostatin, galanin, and PGE2.''; PubMed Europe PMC Scholia
  89. 10.1093/jncics/pkad039; ''''; , DOI Scholia
  90. ''''; , PubMed Europe PMC Scholia
  91. DOI: 10.3389/fpls.2021.668819; ''''; , DOI Scholia
  92. ''''; , PubMed Europe PMC Scholia
  93. Henquin JC, Ishiyama N, Nenquin M, Ravier MA, Jonas JC.; ''Signals and pools underlying biphasic insulin secretion.''; PubMed Europe PMC Scholia
  94. Bakula D, Muller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T; ''WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.''; Nat Commun, 2017 PubMed Europe PMC Scholia
  95. doi: 10.1371/journal.pone.0085164; ''''; , DOI Scholia
  96. DOI: 10.17116/jnevro2021121041151; ''''; , DOI Scholia
  97. Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM; ''Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.''; Br J Pharmacol, 2015 PubMed Europe PMC Scholia
  98. Ostenson CG, Gaisano H, Sheu L, Tibell A, Bartfai T.; ''Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients.''; PubMed Europe PMC Scholia
  99. Froese DS, Zhang J, Healy S, Gravel RA; ''Mechanism of vitamin B12-responsiveness in cblC methylmalonic aciduria with homocystinuria.''; Mol Genet Metab, 2009 PubMed Europe PMC Scholia
  100. 10.1136/jmedgenet-2011-100386; ''''; , DOI Scholia
  101. ''''; , PubMed Europe PMC Scholia
  102. Barg S, Eliasson L, Renström E, Rorsman P.; ''A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.''; PubMed Europe PMC Scholia
  103. https://doi.org/10.1177/1362361319868633; ''''; , DOI Scholia
  104. Barg S, Rorsman P.; ''Insulin secretion: a high-affinity Ca2+ sensor after all?''; PubMed Europe PMC Scholia
  105. DOI: 10.1016/j.nbd.2020.105061; ''''; , PubMed Europe PMC Scholia
  106. DOI: 10.1016/S1075-6280(01)27007-4; ''''; , DOI Scholia
  107. Luvisetto S, Fellin T, Spagnolo M, Hivert B, Brust PF, Harpold MM, Stauderman KA, Williams ME, Pietrobon D.; ''Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits.''; PubMed Europe PMC Scholia
  108. DOI: 10.1038/s41598-017-06782-z; ''''; , DOI Scholia
  109. DOI: 10.3390/genes12050782; ''''; , DOI Scholia
  110. DOI: 10.3389/fpsyt.2022.904091; ''''; , DOI Scholia
  111. http://autism.mindspec.org/GeneDetail/SHANK2; ''''; ,
  112. PMID: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  113. DOI: 10.3390/cells12071087; ''''; , DOI Scholia
  114. DOI: 10.1084/jem.20181965; ''''; , DOI Scholia
  115. Yang SN, Berggren PO.; ''The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology.''; PubMed Europe PMC Scholia
  116. DOI: 10.3390/cells10051081; ''''; , DOI Scholia
  117. 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  118. Raybaud A, Baspinar EE, Dionne F, Dodier Y, Sauvé R, Parent L.; ''The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels.''; PubMed Europe PMC Scholia
  119. doi: 10.1038/s41398-019-0588-1; ''''; , DOI Scholia
  120. Jiang R, Yamaori S, Takeda S, Yamamoto I, Watanabe K; ''Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes.''; Life Sci, 2011 PubMed Europe PMC Scholia
  121. DOI: 10.1016/j.biopsych.2013.03.027; ''''; , DOI Scholia
  122. Zachari M, Ganley IG; ''The mammalian ULK1 complex and autophagy initiation.''; Essays Biochem, 2017 PubMed Europe PMC Scholia
  123. DOI: 10.3390/ijms23073861; ''''; , DOI Scholia
  124. DOI: 10.1111/pcn.12606; ''''; , DOI Scholia
  125. DOI: 10.1089/gtmb.2014.0066; ''''; , DOI Scholia
  126. DOI: 10.3390/ijms23031910; ''''; , DOI Scholia
  127. Memmott RM, Dennis PA; ''Akt-dependent and -independent mechanisms of mTOR regulation in cancer.''; Cell Signal, 2009 PubMed Europe PMC Scholia
  128. http://autism.mindspec.org/GeneDetail/NLGN3; ''''; ,
  129. ''''; , DOI Scholia
  130. DOI: 10.1089/ars.2012.4641; ''''; , PubMed Europe PMC Scholia
  131. 10.3389/fnmol.2022.919773; ''''; , DOI Scholia
  132. DOI: 10.1039/C4RA09872B; ''''; , DOI Scholia
  133. DOI: 10.3390/ijms21155310; ''''; , DOI Scholia
  134. Sher E, Giovannini F, Codignola A, Passafaro M, Giorgi-Rossi P, Volsen S, Craig P, Davalli A, Carrera P.; ''Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications.''; PubMed Europe PMC Scholia
  135. 10.1097/MD.0000000000027858; ''''; , DOI Scholia
  136. DOI: 10.1371/journal.pone.0051330; ''''; , DOI Scholia
  137. DOI: 10.1007/s00702-009-0281-2; ''''; , DOI Scholia
  138. 10.1007/s00213-009-1628-y; ''''; , DOI Scholia
  139. ''''; , PubMed Europe PMC Scholia
  140. DOI: 10.1038/tp.2012.7; ''''; , DOI Scholia
  141. DOI 10.3390/nu8020068; ''Defects of glucose-6-phosphate and 6-phosphogluconate dehydrogenases in Neurospora and their pleiotropic effects.''; Curr Top Cell Regul, 1976 DOI Scholia
  142. ''''; , PubMed Europe PMC Scholia
  143. DOI: 10.3389/fneur.2021.683275; ''''; , DOI Scholia
  144. DOI: 10.3389/fpsyt.2021.780921; ''''; , DOI Scholia
  145. http://autism.mindspec.org/GeneDetail/PTEN; ''''; ,
  146. Rutter GA, Hill EV.; ''Insulin vesicle release: walk, kiss, pause ... then run.''; PubMed Europe PMC Scholia
  147. DOI: 10.1038/mp.2017.255; ''''; , DOI Scholia
  148. Sharp GW.; ''Mechanisms of inhibition of insulin release.''; PubMed Europe PMC Scholia
  149. DOI: 10.1016/j.pneurobio.2020.101906; ''''; , DOI Scholia
  150. https://www.potomacpsychiatry.com/blog/adra2a-gene-test-adhd-genetic-testing; ''''; ,
  151. Tsuboi T, Rutter GA.; ''Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells.''; PubMed Europe PMC Scholia
  152. ''Serum microRNA-501-3p is a potential diagnostic tool for detecting mild cognitive impairment: Ehime genome study.''; J Neurochem, 2023 PubMed Europe PMC Scholia
  153. DOI: https://doi.org/10.1002/iub.114; ''''; , DOI Scholia
  154. DOI 10.3390/cells10051081; ''''; , DOI Scholia
  155. Wolthers KR, Lou X, Toogood HS, Leys D, Scrutton NS; ''Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry.''; Biochemistry, 2007 PubMed Europe PMC Scholia
  156. 10.1016/j.pnpbp.2018.01.013; ''''; , DOI Scholia
  157. https://tmedweb.tulane.edu/pharmwiki/doku.php/amphetamines; ''''; ,
  158. DOI: 10.1038/s41598-021-03885-6; ''''; , DOI Scholia
  159. DOI: 10.1038/s12276-017-0018-5; ''''; , DOI Scholia
  160. 10.1002/ajmg.b.30872; ''''; , DOI Scholia
  161. 10.3389/fmicb.2019.02305; ''''; , DOI Scholia
  162. DOI: 10.1515/cclm-2012-0673; ''''; , DOI Scholia
  163. DOI: 10.1016/j.psychres.2016.10.044; ''''; , DOI Scholia
  164. https://www.genome.jp/pathway/hsa04150; ''''; ,
  165. doi: 10.20517/jtgg.2020.34; ''''; , DOI Scholia
  166. DOI: 10.1016/j.neubiorev.2017.01.013; ''''; , DOI Scholia
  167. doi: 10.1093/scan/nsp049; ''''; , DOI Scholia
  168. DOI: 10.1016/j.molmet.2018.01.007; ''''; , DOI Scholia
  169. 10.31887/DCNS.2012.14.3/jneul; ''''; , DOI Scholia
  170. doi: 10.1016/j.bbadis.2016.10.016; ''''; , DOI Scholia
  171. DOI: 10.3390/cells11233815; ''''; , DOI Scholia
  172. https://medlineplus.gov/genetics/gene/hcfc1/#synonyms; ''''; ,
  173. 10.1111/j.1601-183X.2007.00384.x; ''''; , DOI Scholia
  174. DOI: 10.3389/fendo.2019.00249; ''''; , DOI Scholia
  175. Seino S, Chen L, Seino M, Blondel O, Takeda J, Johnson JH, Bell GI.; ''Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.''; PubMed Europe PMC Scholia
  176. DOI: 10.1016/j.psychres.2012.08.016; ''''; , DOI Scholia
  177. DOI: 10.1016/j.jphs.2022.08.00; ''A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae.''; Biochem Biophys Res Commun, 1975 DOI Scholia
  178. 10.DOI: 10.1080/1028415X.2019.1570442; ''''; , DOI Scholia
  179. DOI: 10.1111/j.1600-079X.2011.00902.x; ''''; , DOI Scholia
  180. 10.1038/sj.mp.4002090; ''''; , DOI Scholia
  181. ''''; , PubMed Europe PMC Scholia
  182. rs1801394; ''''; ,
  183. doi: 10.1002/jimd.12060.; ''''; , DOI Scholia
  184. DOi: 10.3390/ijms23073861; ''''; , DOI Scholia
  185. DOI: 10.1016/j.phrs.2022.106340; ''''; , DOI Scholia
  186. DOI: 10.1038/nature12630; ''''; , DOI Scholia
  187. DOI: 10.1016/j.euroneuro.2012.07.003; ''''; , DOI Scholia
  188. doi: 10.1016/B978-0-12-801238-3.64985-1; ''''; , DOI Scholia
  189. DOI: 10.1016/j.tips.2017.04.001; ''''; , DOI Scholia
  190. Yamada K, Gherasim C, Banerjee R, Koutmos M; ''Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
  191. DOI: 10.3389/fgene.2018.00635; ''''; , DOI Scholia
  192. DOI: 10.1007/s12519-023-00702-0; ''''; , DOI Scholia
  193. Doi: 10.3390/antiox12051037; ''''; , DOI Scholia
  194. 10.DOI: 10.1080/23312025.2019.1606555; ''''; , DOI Scholia
  195. 10.4088/JCP.14l09346; ''''; , DOI Scholia
  196. DOI: 10.4137/IJTR.S8158; ''''; , DOI Scholia
  197. doi: 10.1515/jpem-2012-0293; ''''; , DOI Scholia
  198. DOI: 10.15586/codonpublications.parkinsonsdisease.2018.ch7; ''''; , DOI Scholia
  199. doi: 10.1590/2326-4594-jiems-2019-0007; ''''; , DOI Scholia
  200. Winzell MS, Ahrén B.; ''G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes.''; PubMed Europe PMC Scholia
  201. 10.1007/7854_2011_187; ''''; , DOI Scholia
  202. Funderburk SF, Wang QJ, Yue Z; ''The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.''; Trends Cell Biol, 2010 PubMed Europe PMC Scholia
  203. DOI: 10.1038/s41430-020-0657-9; ''Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH.''; Biochem Biophys Res Commun, DOI Scholia
  204. DOI: 10.1093/nar/gkab1016 RHEA:15889; ''''; , DOI Scholia
  205. https://en.wikipedia.org/wiki/DLG4; ''''; ,
  206. ; ''''; , DOI Scholia
  207. DOI: 10.1038/s41392-022-01081-0; ''''; , DOI Scholia
  208. DOI: 10.1016/S0003-9861(03)00295-9; ''''; , DOI Scholia
  209. Díaz-Alonso J, Guzmán M, Galve-Roperh I; ''Endocannabinoids via CB� receptors act as neurogenic niche cues during cortical development.''; Philos Trans R Soc Lond B Biol Sci, 2012 PubMed Europe PMC Scholia
  210. DOI: 10.1172/JCI121277; ''''; , DOI Scholia
  211. Aylett CH, Sauer E, Imseng S, Boehringer D, Hall MN, Ban N, Maier T; ''Architecture of human mTOR complex 1.''; Science, 2016 PubMed Europe PMC Scholia
  212. doi: 10.1124/jpet.105.085282.; ''''; , DOI Scholia
  213. Peterhoff M, Sieg A, Brede M, Chao CM, Hein L, Ullrich S.; ''Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice.''; PubMed Europe PMC Scholia
  214. Jeon SM; ''Regulation and function of AMPK in physiology and diseases.''; Exp Mol Med, 2016 PubMed Europe PMC Scholia
  215. https://doi.org/10.3390/ijms21228870; ''''; , DOI Scholia
  216. DOI: 10.1021/BI992997S; ''''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
134491view05:19, 22 July 2024EgonwImproved the semantics of the references
134489view04:58, 22 July 2024EgonwRemoved template comments
134394view19:39, 21 July 2024EweitzRemove template comments
130790view09:07, 30 May 2024DeSlAll pathway models in WikiPathways are CC0, other licences are not valid.
129619view16:06, 19 May 2024Alexmadsen1
129618view15:55, 19 May 2024Alexmadsen1split Adderall into Dextroamphetamine
129599view17:29, 17 May 2024Alexmadsen1add beta blockers and connect adrenaline
129450view23:43, 22 April 2024EweitzModified title
128702view21:57, 20 February 2024EgonwFixed two datasources
128690view20:04, 19 February 2024EgonwRemoved redundant RHEA: prefix in two interaction identifiers
128491view01:18, 7 February 2024Alexmadsen1update
128483view04:10, 6 February 2024Alexmadsen1add Purine Synthesis cycle and connection and I connected in ADSL that is #22 on ASD/ADHD list.
128459view19:53, 4 February 2024Alexmadsen1updat PNMT SAD
128458view19:48, 4 February 2024Alexmadsen1add SNP
128312view19:35, 31 January 2024Khanspersupdate with latest changes from Alex Madsen
128112view19:42, 26 January 2024KhanspersReverted to version '19:33, 26 January 2024' by Khanspers
128111view19:39, 26 January 2024KhanspersLatest edits from Alex Madsen
128110view19:33, 26 January 2024KhanspersReverted to version '02:04, 6 January 2024' by Khanspers
128109view19:29, 26 January 2024KhanspersIncorporating latest changes from Alex Madsen
127881view02:04, 6 January 2024EweitzModified description
127879view23:55, 5 January 2024Alexmadsen1uodate TSC1/2 <-->AMPK <-> NOS
127878view23:13, 5 January 2024Alexmadsen1add GPT The linkage between AMPK, NOS, MECP2, PTEN, PRKCB, mTORC1, mTORC2, and their relationship to Autism Spectrum Disorder (ASD) represents a complex network of interactions critical for neuronal function and development.
127877view03:54, 5 January 2024Alexmadsen1added linkage between NOS and 5-MTH per https://doi.org/10.1159/000142363
127876view02:56, 5 January 2024Alexmadsen1added refrences for Cbl / b12 pathway and added methionine synthase interactome
127875view04:15, 4 January 2024Alexmadsen1final check in
127874view03:26, 4 January 2024Alexmadsen1add glycine > guanidinoacetate > creatine and several DOI refrences
127873view01:42, 4 January 2024Alexmadsen1
127869view03:20, 3 January 2024Alexmadsen1general cleanup
127868view03:16, 3 January 2024Alexmadsen1add mTORC1 and mTORC 2 complex and MAPK3 MAPK1
127867view01:01, 3 January 2024Alexmadsen1add PI3K/Akt/mTOR intracellular signaling pathway
127855view03:24, 2 January 2024Alexmadsen1reorganise gudimate recptors
127854view01:19, 2 January 2024Alexmadsen1
127850view18:45, 31 December 2023Alexmadsen1added DRD4 SNP and RD4 VNTR exon III-7 repeat (7R), rs916455, rs1800955
127849view02:16, 30 December 2023Alexmadsen1cleanup
127848view21:43, 28 December 2023Alexmadsen1removed incorrect linkage between DHF to THF and BH2 to BH4
127733view04:05, 30 November 2023Alexmadsen1add Risperidone
127724view04:16, 29 November 2023Alexmadsen1add SAMe to COMT Neurotransmitter Catabolism (Breakdown). Linked COMT SNP to PNMT.
127718view04:44, 28 November 2023Alexmadsen1add NDRI Bupropion (Wellbutrin), fix Guanfacine and Clonidine and other cleanup
127682view23:20, 21 November 2023EweitzModified description
127680view23:14, 21 November 2023EweitzModified title
127675view22:42, 19 November 2023Alexmadsen1clanup
127674view22:24, 19 November 2023Alexmadsen1general cleanup
127672view17:10, 18 November 2023Alexmadsen1add SAME to NA to NM with COMT
127671view05:38, 18 November 2023Alexmadsen1add SAM to SAH conversion for PNMT when convering Norepinephran to Epinephran
127665view02:51, 16 November 2023Alexmadsen1fix floating connections
127664view02:47, 16 November 2023Alexmadsen1add PEA,NMPEA,2-phenylacetaldehyde
127638view14:02, 11 November 2023EgonwFixed more reference identifiers
127637view13:33, 11 November 2023EgonwFixed a few references (removed a few duplicates) and added a missing slash is a DOI
127597view02:09, 3 November 2023Alexmadsen1clean up methods of action in synaptic gap
127596view01:46, 3 November 2023Alexmadsen1

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(4aS,6R)-4a-hydroxy - BH4MetaboliteCHEBI:15642 (ChEBI)
1''-hydroxycannabidiolMetaboliteCHEBI:133056 (ChEBI)
1-O-(1,2-saturated-alkyl)-sn-glycerolMetaboliteCHEBI:83957 (ChEBI)
10-formyl-THFMetaboliteCHEBI:15637 (ChEBI)
11-OH-THCMetaboliteHMDB0060906 (HMDB)
1′-OXPH4MetaboliteHMDB0013642 (HMDB) 1'-oxo-2'-hydroxypropyl-tetrahydropterin
2''-hydroxycannabidiol MetaboliteCHEBI:133058 (ChEBI)
2-AGMetaboliteCHEBI:52392 (ChEBI) 2-arachidonoylglycerol
2-oxoglutarateMetaboliteCHEBI:16810 (ChEBI)
2-phenylacetaldehydeMetaboliteCHEBI:16424 (ChEBI)
2A-3OBUMetaboliteCHEBI:78948 (ChEBI)
2′-OXPH4MetaboliteCHEBI:17248 (ChEBI) 1'-hydroxy-2'-oxopropyl-tetrahydropterin (2'-OXPH4)
3''-hydroxycannabidiol MetaboliteCHEBI:133059 (ChEBI)
3-Hydroxyanthranilic AcidMetaboliteCHEBI:15793 (ChEBI)
3-HydroxykynurenineMetaboliteCHEBI:1547 (ChEBI)
3-MT SOMetaboliteCHEBI:133708 (ChEBI)
3-MTMetaboliteCHEBI:1582 (ChEBI)
4''-hydroxycannabidiol MetaboliteCHEBI:133055 (ChEBI)
4-aminobutanoateMetaboliteCHEBI:30566 (ChEBI)
5''-hydroxycannabidiol MetaboliteCHEBI:133062 (ChEBI)
5, 10-MTHFPGMetaboliteCHEBI:60976 (ChEBI)
5-10MeTHFMetaboliteCHEBI:20502 (ChEBI)
5-HIAAMetaboliteCHEBI:27823 (ChEBI) AKA 5-HIAA
5-HialMetaboliteCHEBI:50157 (ChEBI)
5-MTMetaboliteCHEBI:2089 (ChEBI)
5-MTHFMetaboliteCHEBI:15641 (ChEBI)
5-hydroxy-L-tryptophanMetaboliteCHEBI:58266 (ChEBI)
6R-BH4MetaboliteCHEBI:59560 (ChEBI)
6a-hydroxycannabidiol MetaboliteCHEBI:133049 (ChEBI)
6b-hydroxycannabidiol MetaboliteCHEBI:133052 (ChEBI)
7-hydroxycannabidiol MetaboliteCHEBI:133053 (ChEBI)
AADATProteinQ8N5Z0 (Uniprot-TrEMBL)
AANATProteinQ16613 (Uniprot-TrEMBL)
AATMProteinP00505 (Uniprot-TrEMBL)
ABATProteinP80404 (Uniprot-TrEMBL) 4-Aminobutyrate aminotransferase
ABL1ProteinP00519 (Uniprot-TrEMBL)
ABL2ProteinP42684 (Uniprot-TrEMBL)
ACEGeneProductP12821 (Uniprot-TrEMBL)
ADAM10ProteinO14672 (Uniprot-TrEMBL)
ADCY1GeneProductCHEBI:58165 (Uniprot-TrEMBL)
ADCY7GeneProductADCY7 (Uniprot-TrEMBL)
ADGRL3 GPCRsProteinQ9HAR2 (Uniprot-TrEMBL)
ADHProteinEC 1.1.1.1 (KEGG Genes)
ADORA2AGeneProductP29274 (Uniprot-TrEMBL)
ADRA1AProteinP35348 (Uniprot-TrEMBL)
ADRA1BGeneProductP35368 (Uniprot-TrEMBL)
ADRA1DGeneProductP25100 (Uniprot-TrEMBL)
ADRA2AGeneProduct266750 (Entrez Gene)
ADRA2BGeneProduct266751 (Entrez Gene)
ADRA2CGeneProduct266752 (Entrez Gene)
ADRB1GeneProduct557194 (Entrez Gene)
ADRB2GeneProductP07550 (Uniprot-TrEMBL)
ADRB3aGeneProduct558248 (Entrez Gene)
AEAMetaboliteCHEBI:2700 (ChEBI) anandamide
AGMOProteinQ6ZNB7 (Uniprot-TrEMBL)
AGTR1ProteinP30556 (Uniprot-TrEMBL)
AHCYL1ProteinO43865 (Uniprot-TrEMBL)
AHCYProteinP23526 (Uniprot-TrEMBL)
AKRProtein
AKR1A1ProteinP14550 (Uniprot-TrEMBL)
AKR1B1ProteinP15121 (Uniprot-TrEMBL)
AKR1C1ProteinQ04828 (Uniprot-TrEMBL)
AKR1C3ProteinP42330 (Uniprot-TrEMBL)
AKT1GeneProductP31749 (Uniprot-TrEMBL)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AKT2GeneProductP31751 (Uniprot-TrEMBL)
AKT3GeneProductQ9Y243 (Uniprot-TrEMBL)
ALDHProtein
ALDH1L1ProteinO75891 (Uniprot-TrEMBL)
ALDH1L2ProteinQ3SY69 (Uniprot-TrEMBL)
ALDH2ProteinP05091 (Uniprot-TrEMBL)
ALDH5A1ProteinCHEBI:57706 (Uniprot-TrEMBL)
ALDH9A1ProteinP49189 (Uniprot-TrEMBL) 4-trimethylaminobutyraldehyde dehydrogenase
AOC1GeneProductP19801 (Uniprot-TrEMBL)
APPProteinP05067 (Uniprot-TrEMBL)
ASMTProteinP46597 (Uniprot-TrEMBL)
ATPMetaboliteHMDB0000538 (HMDB)
AdoCblMetaboliteCHEBI:18408 (ChEBI)
Alpha-dystroglycanProtein
AngiotensinogenMetaboliteCHEBI:2720 (ChEBI)
Anthranilic AcidMetaboliteCHEBI:16567 (ChEBI)
Anti-inflammatory pathwaysPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
B2 riboflavinMetaboliteCHEBI:17015 (ChEBI)
B2MetaboliteCHEBI:17015 (ChEBI)
B6 pyridoxineMetaboliteCHEBI:16709 (ChEBI)
B9MetaboliteCHEBI:27470 (ChEBI)
BH2 7,8-dihydrofolateMetaboliteCHEBI:64240 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
BHMTProteinQ93088 (Uniprot-TrEMBL)
Beta-dystroglycanProtein
BiopterinMetaboliteCHEBI:15373 (ChEBI)
CACNA1CProteinQ13936 (Uniprot-TrEMBL)
CACNG1ProteinQ06432 (Uniprot-TrEMBL)
CACNG2ProteinQ9Y698 (Uniprot-TrEMBL)
CACNG3ProteinO60359 (Uniprot-TrEMBL)
CACNG4ProteinQ9UBN1 (Uniprot-TrEMBL)
CACNG5ProteinQ9UF02 (Uniprot-TrEMBL)
CACNG6ProteinQ9BXT2 (Uniprot-TrEMBL)
CACNG7ProteinP62955 (Uniprot-TrEMBL)
CACNG8ProteinQ8WXS5 (Uniprot-TrEMBL)
CALM3GeneProductP0DP23 (Uniprot-TrEMBL)
CB CollybistinProtein
CBDMetaboliteCHEBI:69478 (ChEBI)
CBLProteinP22681 (Uniprot-TrEMBL)
CBR1ProteinP16152 (Uniprot-TrEMBL)
CBSProteinP35520 (Uniprot-TrEMBL)
CD320ProteinQ9NPF0 (Uniprot-TrEMBL) Aka CD320 receptor
CDO1GeneProductQ16878 (Uniprot-TrEMBL)
CNR1GeneProductP21554 (Uniprot-TrEMBL) CB1
CNR2GeneProductP34972 (Uniprot-TrEMBL) CB2
CNTN1GeneProductQ9UQ52 (Uniprot-TrEMBL)
CNTN2GeneProductO94779 (Uniprot-TrEMBL)
CNTN3GeneProductQ8IWV2 (Uniprot-TrEMBL)
CNTN4GeneProductQ9P232 (Uniprot-TrEMBL)
CNTN5GeneProductQ02246 (Uniprot-TrEMBL)
CNTN6GeneProductQ12860 (Uniprot-TrEMBL)
CNTNAP1GeneProductP78357 (Uniprot-TrEMBL)
CNTNAP2GeneProductQ9UHC6 (Uniprot-TrEMBL)
CNTNAP3GeneProductQ9BZ76 (Uniprot-TrEMBL)
CNTNAP4GeneProductQ9C0A0 (Uniprot-TrEMBL)
COMT InhibitorsMetabolite
COMTProteinP21964 (Uniprot-TrEMBL) AKA Catechol-O- metyltransferase
COOH-THCMetaboliteCHEBI:77273 (ChEBI)
CPLX1ProteinO14810 (Uniprot-TrEMBL)
CSADProteinQ9Y600 (Uniprot-TrEMBL)
CTHProteinP32929 (Uniprot-TrEMBL)
CTNNB1GeneProductENSG00000168036 (Ensembl)
CTTNProteinQ14247 (Uniprot-TrEMBL)
CYP2C19GeneProductENSG00000165841 (Ensembl)
CYP2C9GeneProductENSG00000138109 (Ensembl)
CYP2D6ProteinP10635 (Uniprot-TrEMBL)
CYP3A4GeneProductENSG00000160868 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
CblD MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-1 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblD-2 MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
CblMetaboliteQ3329800 (Wikidata)
ClonidineMetaboliteCHEBI:46631 (ChEBI)
CortactinGeneProductENSG00000085733 (Ensembl)
DAG1GeneProductQ14118 (Uniprot-TrEMBL)
DAGMetaboliteC00165 (KEGG Drug)
DAGLAGeneProductENSG00000134780 (Ensembl)
DAGLBGeneProductENSG00000164535 (Ensembl)
DBHProteinP09172 (Uniprot-TrEMBL)
DDCProteinP20711 (Uniprot-TrEMBL)
DEPTORGeneProductENSG00000155792 (Ensembl)
DHFMetaboliteCHEBI:23743 (ChEBI)
DHFRProteinP00374 (Uniprot-TrEMBL)
DHMAMetaboliteCHEBI:27637 (ChEBI)
DHNTPMetaboliteCHEBI:18372 (ChEBI)
DHPGMetaboliteCHEBI:1387 (ChEBI)
DLG1ProteinQ12959 (Uniprot-TrEMBL)
DLG2ProteinQ15700 (Uniprot-TrEMBL)
DLG3ProteinQ92796 (Uniprot-TrEMBL)
DLG4ProteinP78352 (Uniprot-TrEMBL)
DLG5ProteinQ8TDM6 (Uniprot-TrEMBL)
DLGAP1GeneProductO14490 (Uniprot-TrEMBL)
DLGAP2GeneProductQ9P1A6 (Uniprot-TrEMBL)
DLGAP3GeneProductO95886 (Uniprot-TrEMBL)
DLGAP4GeneProductQ9Y2H0 (Uniprot-TrEMBL)
DLGAP5GeneProductQ15398 (Uniprot-TrEMBL)
DNMT1ProteinP26358 (Uniprot-TrEMBL)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DOPEGMetaboliteCHEBI:1387 (ChEBI)
DOPETMetaboliteCHEBI:68889 (ChEBI)
DOPGAL MetaboliteCHEBI:180943 (ChEBI)
DOPLMetaboliteCHEBI:27978 (ChEBI)
DRD1GeneProduct568126 (Entrez Gene)
DRD2GeneProductP14416 (Uniprot-TrEMBL)
DRD3GeneProduct282554 (Entrez Gene)
DRD4 VNTR exon III-7rRna
DRD4GeneProductP21917 (Uniprot-TrEMBL)
DRD5ProteinP21918 (Uniprot-TrEMBL)
Derived From WP3869 Cannabinoid receptor signalingPathwayWP3869 (WikiPathways)
Derived From WP4159 GABA receptor signalingPathwayWP4159 (WikiPathways)
Derived From WP4271 Vitamin B12 disordersPathwayWP4271 (WikiPathways)
Dextroamphetamine + Amphetamine (Adderall)MetaboliteCHEBI:2679 (ChEBI)
EGFRProteinP00533 (Uniprot-TrEMBL)
F-actinGeneProduct
FAAH2GeneProductQ6GMR7 (Uniprot-TrEMBL)
FAAHGeneProductENSG00000117480 (Ensembl)
FADMetaboliteCHEBI:57692 (ChEBI) cofactor
FLAD1MetaboliteQ8NFF5 (ChEBI)
FMNMetabolitecHEBI:58210 (ChEBI) cofactor
FMO1GeneProductQ01740 (Uniprot-TrEMBL)
FMO3GeneProductQ01740 (Uniprot-TrEMBL)
FOLH1GeneProductQ04609 (Uniprot-TrEMBL)
FOLR1ProteinP15328 (Uniprot-TrEMBL)
FOLR2ProteinP14207 (Uniprot-TrEMBL)
Fe2+MetaboliteCHEBI:29033 (ChEBI)
GABAMetaboliteCHEBI:59888 (ChEBI)
GABBR1ProteinQ9UBS5 (Uniprot-TrEMBL)
GABRA1ProteinP14867 (Uniprot-TrEMBL)
GABRA2ProteinP47869 (Uniprot-TrEMBL)
GABRA3ProteinP34903 (Uniprot-TrEMBL)
GABRA4ProteinP48169 (Uniprot-TrEMBL)
GABRA5ProteinP31644 (Uniprot-TrEMBL)
GABRB1ProteinP18505 (Uniprot-TrEMBL)
GABRB2ProteinP47870 (Uniprot-TrEMBL)
GABRB3ProteinP28472 (Uniprot-TrEMBL)
GABRDProteinO14764 (Uniprot-TrEMBL)
GABRG1ProteinQ8N1C3 (Uniprot-TrEMBL)
GABRG2ProteinP18507 (Uniprot-TrEMBL)
GABRQProteinQ9UN88 (Uniprot-TrEMBL)
GAD1GeneProductQ99259 (Uniprot-TrEMBL)
GAD2GeneProductQ05329 (Uniprot-TrEMBL)
GATMGeneProductP50440 (Uniprot-TrEMBL)
GCATGeneProductO75600 (Uniprot-TrEMBL)
GCH1ProteinP30793 (Uniprot-TrEMBL)
GKAP1GeneProductQ5VSY0 (Uniprot-TrEMBL)
GKProteinP32189 (Uniprot-TrEMBL)
GLS2ProteinQ9UI32 (Uniprot-TrEMBL)
GLSProteinO94925 (Uniprot-TrEMBL)
GLULGeneProductP15104 (Uniprot-TrEMBL)
GNAQProteinP50148 (Uniprot-TrEMBL)
GPHNProteinQ9NQX3 (Uniprot-TrEMBL)
GRIA1ProteinP42261 (Uniprot-TrEMBL)
GRIA2ProteinP42262 (Uniprot-TrEMBL)
GRIA3ProteinP42263 (Uniprot-TrEMBL)
GRIA4ProteinP48058 (Uniprot-TrEMBL)
GRIN1ProteinQ05586 (Uniprot-TrEMBL)
GRIN2AProteinQ12879 (Uniprot-TrEMBL)
GRIN2BProteinQ13224 (Uniprot-TrEMBL)
GRIN2CProteinQ14957 (Uniprot-TrEMBL)
GRIN2DProteinO15399 (Uniprot-TrEMBL)
GRIN3AProteinQ8TCU5 (Uniprot-TrEMBL)
GRIN3BProteinO60391 (Uniprot-TrEMBL)
GRIP1ProteinQ9Y3R0 (Uniprot-TrEMBL)
GRIP2ProteinQ9C0E4 (Uniprot-TrEMBL)
GRM1ProteinQ13255 (Uniprot-TrEMBL)
GRM2ProteinQ14416 (Uniprot-TrEMBL)
GRM3ProteinQ14832 (Uniprot-TrEMBL)
GRM4ProteinQ14833 (Uniprot-TrEMBL)
GRM5ProteinP41594 (Uniprot-TrEMBL)
GRM6ProteinO15303 (Uniprot-TrEMBL)
GRM7ProteinQ14831 (Uniprot-TrEMBL)
GRM8ProteinO00222 (Uniprot-TrEMBL)
GeneProductGeneProduct
GuanfacineMetaboliteHMDB15153 (HMDB)
H2O2Metabolite16240 (ChEBI)
H4gtp GPTMetaboliteCHEBI: (ChEBI)
HCFC1 (cblX)GeneProductP51610 (Uniprot-TrEMBL)
HDCGeneProductP19113 (Uniprot-TrEMBL)
HISN8ProteinQ9C5U8 (Uniprot-TrEMBL)
HNMTGeneProductP50135 (Uniprot-TrEMBL)
HOMERGeneProduct
HOMER1ProteinQ86YM7 (Uniprot-TrEMBL)
HOMER2ProteinQ9NSB8 (Uniprot-TrEMBL)
HOMER3ProteinQ9NSC5 (Uniprot-TrEMBL)
HTR1AProtein100001828 (Entrez Gene)
HTR1BProtein561647 (Entrez Gene)
HTR1DProteinP28221 (Uniprot-TrEMBL)
HTR1EProteinP28566 (Uniprot-TrEMBL)
HTR1FProteinP30939 (Uniprot-TrEMBL)
HTR2AProteinP28223 (Uniprot-TrEMBL)
HTR2BProteinP41595 (Uniprot-TrEMBL)
HTR2CProtein
HTR3AProteinP40227 (Uniprot-TrEMBL)
HTR3BProteinO95264 (Uniprot-TrEMBL)
HTR3CProteinQ8WXA8 (Uniprot-TrEMBL)
HTR3DProteinQ70Z44 (Uniprot-TrEMBL)
HTR3EProteinA5X5Y0 (Uniprot-TrEMBL)
HTR4ProteinQ13639 (Uniprot-TrEMBL)
HTR5aProtein100038775 (Entrez Gene)
HTR5bProtein
HTR6ProteinP50406 (Uniprot-TrEMBL)
HTR7ProteinP34969 (Uniprot-TrEMBL)
HVAMetaboliteCHEBI:545959 (ChEBI) AKA HVA
HVALMetaboliteCHEBI:173769 (ChEBI) HVAL = Homovanillyl = alcohol(4-Hydroxy-3-methoxyphenyl)ethanol
IDO1ProteinP14902 (Uniprot-TrEMBL)
IDO2ProteinQ6ZQW0 (Uniprot-TrEMBL)
IFNGProteinP01579 (Uniprot-TrEMBL)
INFAProtein
INSRProteinP06213 (Uniprot-TrEMBL)
Imidazole-4-acetateMetaboliteCHEBI:16974 (ChEBI)
KAT1ProteinQ16773 (Uniprot-TrEMBL)
KAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KCNA1ProteinQ09470 (Uniprot-TrEMBL)
KCNA2ProteinP16389 (Uniprot-TrEMBL)
KCNA3ProteinP22001 (Uniprot-TrEMBL)
KCNA4ProteinP22459 (Uniprot-TrEMBL)
KCNA5ProteinP22460 (Uniprot-TrEMBL)
KCNA6ProteinP17658 (Uniprot-TrEMBL)
KCNA7ProteinQ96RP8 (Uniprot-TrEMBL)
KITProteinP10721 (Uniprot-TrEMBL)
KMOProteinO15229 (Uniprot-TrEMBL)
KUVAN (BH4 Supplement) MetaboliteCHEBI:15372 (ChEBI)
KYAT3ProteinQ6YP21 (Uniprot-TrEMBL)
KYNUProteinQ16719 (Uniprot-TrEMBL)
Ketamine MetaboliteCHEBI:6121 (ChEBI)
Kynurenic AcidMetaboliteCHEBI:58454 (ChEBI)
KynurenineMetaboliteCHEBI:57959 (ChEBI)
L-AspMetaboliteCHEBI:29991 (ChEBI)
L-alanineMetabolite57972 (ChEBI)
L-arginineMetaboliteCHEBI:32682 (ChEBI)
L-citrullineMetaboliteCHEBI:57743 (ChEBI)
L-cysteateMetaboliteCHEBI:58090 (ChEBI)
L-cysteineMetaboliteCHEBI:35235 (ChEBI)
L-dopaMetaboliteCHEBI:57504 (ChEBI)
L-glutamateMetaboliteCHEBI:29985 (ChEBI)
L-glutamineMetaboliteCHEBI:58359 (ChEBI)
L-histidineMetaboliteCHEBI:57595 (ChEBI)
L-histidinolMetaboliteCHEBI:57699 (ChEBI)
L-ornithineMetaboliteCHEBI:46911 (ChEBI)
L-phenylalanineMetaboliteCHEBI:58095 (ChEBI)
L-threonineMetaboliteCHEBI:57926 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
L-tyrosineMetaboliteCHEBI:58315 (ChEBI)
MAO Inhibitors MAOIsMetabolite
MAOAProteinP21397 (Uniprot-TrEMBL)
MAOBProteinP27338 (Uniprot-TrEMBL)
MAPK GeneProduct2.7.11.24 (Enzyme Nomenclature)
MAPK1ProteinP28482 (dbSNP)
MAPK3ProteinP27361 (dbSNP)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MAT1AProteinQ00266 (Uniprot-TrEMBL)
MAT2BProteinQ9NZL9 (Uniprot-TrEMBL)
MC4RProteinP32245 (Uniprot-TrEMBL)
MG2+MetaboliteCHEBI:18420 (ChEBI)
MHPG MOPEGMetaboliteCHEBI:1576 (ChEBI)
MLST8GeneProductENSG00000167965 (Ensembl)
MMAB cblBProtein60488 (Uniprot-TrEMBL) gene: MMAB
MMADHCProteinQ9H3L0 (Uniprot-TrEMBL)
  • "cblD protein might be responsible for branching of the cobalamin metabolism pathways to the cytosolic or mitochondrial compartments" Pubmed: 21114891
  • gene is called MMADHC
MMUTProteinP22033 (Uniprot-TrEMBL) aka methylmalonyl-CoA mutase or MCM
MN-SO4MetaboliteHMDB0240719 (HMDB)
MN2+MetaboliteCHEBI:29035 (ChEBI)
MOCOSProteinQ96EN8 (Uniprot-TrEMBL)
MOPGALMetabolite27932 (ChEBI)
MTHFD1LProteinQ6UB35 (Uniprot-TrEMBL)
MTHFD1ProteinP11586 (Uniprot-TrEMBL)
MTHFD2LProteinQ9H903 (Uniprot-TrEMBL)
MTHFD2ProteinP13995 (Uniprot-TrEMBL)
MTHFRProteinP42898 (Uniprot-TrEMBL)
MTORGeneProductENSG00000198793 (Ensembl)
  • effect of AKT on MTOR is indirect
  • Part of two multiprotein complexes, TORC 1 and TORC 2
MTORProteinP42345 (Uniprot-TrEMBL)
MTRProteinQ99707 (Uniprot-TrEMBL)
MTRRProteinQ9UBK8 (Uniprot-TrEMBL)
MeCbl(III)alaminMetaboliteCHEBI:28115 (ChEBI)
MetMetaboliteCHEBI:64558 (ChEBI)
MetaboliteMetabolite
MetanephrineMetaboliteCHEBI:89633 (ChEBI)
Methylmalonyl-CoAMetaboliteCHEBI:16625 (ChEBI)
Methylphenidate(Ritalin)MetaboliteHMDB14566 (HMDB)
MoCoMetabolite71302 (ChEBI)
N-METHYL-HISTAMINEMetaboliteCHEBI:58600 (ChEBI)
N-MethylhistamineMetaboliteCHEBI:29009 (ChEBI)
NA AldehydeMetabolite
NAD+MetaboliteCHEBI:13389 (ChEBI)
NADPMetaboliteCHEBI:58349 (ChEBI)
NADPHMetaboliteCHEBI:57783 (ChEBI)
NADSYN1ProteinQ6IA69 (Uniprot-TrEMBL)
NAPEMetaboliteCHEBI:61232 (ChEBI)
NAPEPLDProteinNAPEPLD (Uniprot-TrEMBL)
NASMetaboliteCHEBI:17697 (ChEBI)
NCAM1ProteinP13591 (Uniprot-TrEMBL)
NDRI Bupropion (Wellbutrin)MetaboliteDB01156 (DrugBank)
NLGN1ProteinQ8N2Q7 (Uniprot-TrEMBL)
NLGN2ProteinQ8NFZ4 (Uniprot-TrEMBL)
NLGN3ProteinQ9NZ94 (Uniprot-TrEMBL)
NLGN4XProteinQ8N0W4 (Uniprot-TrEMBL)
NM Aldehyde Metabolite
NMN-SOMetaboliteHMDB0240719 (HMDB)
NMNAT1ProteinQ9HAN9 (Uniprot-TrEMBL)
NMPEAMetaboliteCHEMBL45763 (ChEMBL compound)
NOMetabolite16480 (ChEBI)
NOS1ProteinP29475 (Uniprot-TrEMBL)
NOS2ProteinP35228 (Uniprot-TrEMBL)
NOS3ProteinP29474 (Uniprot-TrEMBL)
NOX1ProteinQ9Y5S8 (Uniprot-TrEMBL)
NOX3ProteinQ9HBY0 (Uniprot-TrEMBL)
NOX4ProteinQ9NPH5 (Uniprot-TrEMBL)
NOX5ProteinQ96PH1 (Uniprot-TrEMBL)
NRIs

(Atomoxetine /Strattera,

Reboxetine /Edronax & Vestra)		Metabolite
NRXN1ProteinQ9ULB1 (Uniprot-TrEMBL)
NRXN2ProteinP58401 (Uniprot-TrEMBL)
NRXN3ProteinQ9HDB5 (Uniprot-TrEMBL)
Norepinephrine NAMetaboliteCHEBI:72587 (ChEBI)
Normetanephrine NMMetaboliteCHEBI:89951 (ChEBI)
O2MetaboliteCHEBI:5379 (ChEBI)
O2−MetaboliteCHEBI:18421 (ChEBI)
OH-MetaboliteCHEBI:16234 (ChEBI)
ONOO-MetaboliteCHEBI:25941 (ChEBI)
OPRM1ProteinP35372 (Uniprot-TrEMBL)
OXTProteinP01178 (Uniprot-TrEMBL)
OXTRProteinP30559 (Uniprot-TrEMBL)
P
PAHProteinP00439 (Uniprot-TrEMBL)
PCBD1ProteinP61457 (Uniprot-TrEMBL)
PCBD2ProteinQ9H0N5 (Uniprot-TrEMBL)
PDGFRAProteinP16234 (Uniprot-TrEMBL)
PDGFRBProteinP09619 (Uniprot-TrEMBL)
PDXKProteinO00764 (Uniprot-TrEMBL)
PIK3AP1GeneProductQ6ZUJ8 (Uniprot-TrEMBL)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3CB ProteinP42338 (Uniprot-TrEMBL)
PIK3CDProteinO00329 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIK3R3ProteinQ92569 (Uniprot-TrEMBL)
PIP2MetaboliteQ413692 (Wikidata)
PIP3MetaboliteCHEBI:16618 (ChEBI)
PLCBGeneProductP50148 (Uniprot-TrEMBL)
PLCG1GeneProductP19174 (Uniprot-TrEMBL)
PLCG2GeneProductP16885 (Uniprot-TrEMBL)
PLP pyridoxal 5'-phosphateMetaboliteCHEBI:597326 (ChEBI)
PLPMetaboliteCHEBI:597326 (ChEBI)
PNMTProteinP11086 (Uniprot-TrEMBL)
PNPOProteinQ9NVS9 (Uniprot-TrEMBL)
PPH4MetaboliteCHEBI:17804 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKAR1AGeneProductENSG00000108946 (Ensembl)
PRKAR1BGeneProductENSG00000188191 (Ensembl)
PRKAR2AGeneProductENSG00000114302 (EMBL)
PRKAR2BGeneProductENSG00000005249 (Ensembl)
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCB ProteinP05771 (Uniprot-TrEMBL)
PRKCD ProteinQ05655 (Uniprot-TrEMBL)
PRKCG ProteinP05129 (Uniprot-TrEMBL)
PRKCZ ProteinQ05513 (Uniprot-TrEMBL)
PSD95GeneProductP78352 (Uniprot-TrEMBL)
PTENGeneProductP60484 (Uniprot-TrEMBL)
PTK2BProteinQ14289 (Uniprot-TrEMBL)
PTSProteinQ03393 (Uniprot-TrEMBL)
Pharmacological

Intervention

(drug)
PhosphatidylethanolamineMetaboliteHMDB0060501 (HMDB)
Picolinic AcidMetaboliteCHEBI:28747 (ChEBI)
PrazosinMetaboliteHMDB14600 (HMDB)
ProteinProtein
QDPRProteinP09417 (Uniprot-TrEMBL)
QPRTProteinQ15274 (Uniprot-TrEMBL)
QUINMetaboliteCHEBI:16675 (ChEBI)
Quinolinic Acid QUINMetaboliteCHEBI:16675 (ChEBI)
R-cob(III)alaminMetaboliteCHEBI:140785 (ChEBI)
RENProteinP00797 (Uniprot-TrEMBL)
RFKProteinQ969G6 (Uniprot-TrEMBL)
RHEBProteinQ15382 (Uniprot-TrEMBL)
RHOAProteinP61586 (Uniprot-TrEMBL)
RICTORGeneProductENSG00000164327 (Ensembl)
RIT2ProteinQ99578 (Uniprot-TrEMBL)
RPTORGeneProductENSG00000141564 (Ensembl)
RisperidoneMetaboliteDB00734 (DrugBank)
S-SCAMGeneProduct
S-adenosyl-L-homocysteineMetaboliteCHEBI:57856 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SAM

SAMe

MetaboliteCHEBI:59789 (ChEBI)
SAMe MetaboliteCHEBI:59789 (ChEBI)
SAPAPGeneProduct
SCN10AProteinQ9Y5Y9 (Uniprot-TrEMBL)
SCN11AProteinQ9UI33 (Uniprot-TrEMBL)
SCN1AProteinP35498 (Uniprot-TrEMBL)
SCN1BProteinQ07699 (Uniprot-TrEMBL)
SCN2AProteinQ99250 (Uniprot-TrEMBL)
SCN2BProteinO60939 (Uniprot-TrEMBL)
SCN3AProteinQ9NY46 (Uniprot-TrEMBL)
SCN3BProteinQ9NY72 (Uniprot-TrEMBL)
SCN4AProteinP35499 (Uniprot-TrEMBL)
SCN4BProteinQ8IWT1 (Uniprot-TrEMBL)
SCN5AProteinQ14524 (Uniprot-TrEMBL)
SCN7AProteinQ01118 (Uniprot-TrEMBL)
SCN8AProteinQ9UQD0 (Uniprot-TrEMBL)
SCN9AProteinQ15858 (Uniprot-TrEMBL)
SHANKGeneProduct
SHANK1ProteinQ9Y566 (Uniprot-TrEMBL)
SHANK2ProteinQ9UPX8 (Uniprot-TrEMBL)
SHANK3ProteinQ9BYB0 (Uniprot-TrEMBL)
SHMT1ProteinP34896 (Uniprot-TrEMBL)
SHMT2ProteinP34897 (Uniprot-TrEMBL)
SIRT3GeneProductQ9NTG7 (Uniprot-TrEMBL)
SLC17A6GeneProductQ9P2U8 (Uniprot-TrEMBL)
SLC17A7ProteinQ9P2U8 (Uniprot-TrEMBL) Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10820226). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (By similarity).
SLC17A8GeneProductQ9P2U8 (Uniprot-TrEMBL)
SLC18A1ProteinP54219 (Uniprot-TrEMBL)
SLC19A1ProteinP41440 (Uniprot-TrEMBL)
SLC25A12ProteinO75746 (Uniprot-TrEMBL)
SLC25A13ProteinQ9UJS0 (Uniprot-TrEMBL)
SLC25A32ProteinQ9H2D1 (Uniprot-TrEMBL)
SLC32A1ProteinQ9H598 (Uniprot-TrEMBL) Vesicular inhibitory amino acid transporter
SLC46A1ProteinQ96NT5 (Uniprot-TrEMBL)
SLC52A1GeneProductQ9NWF4 (Uniprot-TrEMBL)
SLC52A2GeneProductQ9HAB3 (Uniprot-TrEMBL)
SLC52A3GeneProductQ9NQ40 (Uniprot-TrEMBL)
SLC6A1GeneProductP30531 (Uniprot-TrEMBL)
SLC6A2ProteinP23975 (Uniprot-TrEMBL)
SLC6A3ProteinQ01959 (Uniprot-TrEMBL) Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3. AKA DAT1
SLC6A4ProteinP31645 (Uniprot-TrEMBL)
SNAP25ProteinP60880 (Uniprot-TrEMBL)
SNP

single nucleotide

polymorphism		Rna
SNRIs

(Desvenlafaxine, Duloxetine, Levomilnacipran, Milnacipran

Venlafaxine)		Metabolite
SOD1ProteinP00441 (Uniprot-TrEMBL)
SOD2ProteinP04179 (Uniprot-TrEMBL)
SOD3ProteinP08294 (Uniprot-TrEMBL)
SPRProteinP35270 (Uniprot-TrEMBL)
SRBS2ProteinO94875 (Uniprot-TrEMBL)
SSRIs

(fluoxetine, citalopram, sertraline, paroxetine,

escitalopram)		Metabolite
STX1AProteinQ16623 (Uniprot-TrEMBL)
STXBP1ProteinP61764 (Uniprot-TrEMBL)
SULT1A3ProteinP0DMM9 (Uniprot-TrEMBL)
SYPProteinP08247 (Uniprot-TrEMBL)
SYT1ProteinP21579 (Uniprot-TrEMBL)
Succinyl-CoAMetaboliteCHEBI:15380 (ChEBI)
T23OProteinP48775 (Uniprot-TrEMBL)
TAAR1ProteinQ96RJ0 (Uniprot-TrEMBL)
TBCD7ProteinNon-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex
TCN2ProteinP20062 (Uniprot-TrEMBL)
TDC Protein
THCMetaboliteHMDB0041865 (HMDB)

  • Tetrahydrocannabinol (THC) is the primary psychoactive compound found in cannabis plants. Its effects on cannabinoid receptors CNR1 (CB1) and CNR2 (CB2) are well-documented:

    CB1 Receptor Interaction:

    THC is a partial agonist at the CB1 receptor. When it binds to the CB1 receptor, it activates the receptor to a degree, eliciting a psychoactive response which is often associated with the "high" experienced from cannabis consumption. CB2 Receptor Interaction:

    THC is also a partial agonist at the CB2 receptor, although its affinity for the CB2 receptor is less compared to the CB1 receptor. The activation of CB2 receptors by THC is associated with some of the medicinal properties of cannabis, such as its anti-inflammatory effects.

    In summary, THC acts as a partial agonist at both CB1 and CB2 receptors, stimulating these receptors to produce a variety of effects in the body, including psychoactive and potential therapeutic effects. Unlike CBD, THC does not act as an antagonist or inhibitor at these receptors, and its binding and activation of CB1 and CB2 receptors are central to its effects.
  • Type your comment here
THF-polyglutamateMetaboliteCHEBI:28624 (ChEBI)
THFMetaboliteCHEBI:26907 (ChEBI)
TNFAProteinP01375 (Uniprot-TrEMBL)
TPH1ProteinP17752 (Uniprot-TrEMBL)
TPH2ProteinQ8IWU9 (Uniprot-TrEMBL)
TSC1ProteinQ92574 (Uniprot-TrEMBL)
TSC2ProteinP49815 (Uniprot-TrEMBL)
TYMSProteinP04818 (Uniprot-TrEMBL)
TYProteinP07101 (Uniprot-TrEMBL)
VAMP2ProteinP63027 (Uniprot-TrEMBL)
VMAMetaboliteCHEBI:27622 (ChEBI)
Viloxazine (Qelbree)MetaboliteCHEBI:94405 (ChEBI)
Xanthurenic acidMetaboliteCHEBI:10072 (ChEBI)
a 1-(1-hydroxyalkyl)-sn-glycerolMetaboliteCHEBI:73418 (ChEBI)
acetateMetaboliteCHEBI:58251 (ChEBI)
adrenalineMetaboliteCHEBI:28918 (ChEBI)
alkylglycerolsMetaboliteCHEBI:52575 (ChEBI)
angiotensin IMetaboliteCHEBI:147350 (ChEBI)
angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
arachidonic acidMetaboliteCHEBI:15843 (ChEBI)
cAMP MetaboliteCHEBI:58165 (ChEBI)
cbLA MMAAProteinQ8IVH4 (Uniprot-TrEMBL) Gene: MMAA
cbLC MMACHCProteinQ9Y4U1 (Uniprot-TrEMBL) Gene is called MMAC
cblF LMBRD1ProteinQ9NUN5 (Uniprot-TrEMBL)
cblJ ABCD4ProteinO14678 (Uniprot-TrEMBL)
citrate cyclePathwayWP78 (WikiPathways)
cob(I)alaminMetaboliteCHEBI:15982 (ChEBI)
cob(II)alaminMetaboliteCHEBI:16304 (ChEBI) Should be cob(II)alamin according to literature
creatineMetaboliteCHEBI:57947 (ChEBI)
cystathionineMetaboliteCHEBI:58161 (ChEBI)
cysteine sulfinateMetaboliteCHEBI:61085 (ChEBI)
deamido-NAD+MetaboliteCHEBI:58437 (ChEBI)
dopamineMetaboliteCHEBI:59905 (ChEBI)
fatty aldehydesMetaboliteCHEBI:35746 (ChEBI)
formateMetaboliteCHEBI:15740 (ChEBI)
gamma-hydroxybutyrate MetaboliteQ207920 (Wikidata)
glycerol 3-phosphateMetaboliteCHEBI:57597 (ChEBI)
glycerolMetaboliteCHEBI:17754 (ChEBI)
glycine betaineMetaboliteCHEBI:17750 (ChEBI)
glycineMetaboliteCHEBI:57305 (ChEBI)
guanidinoacetateMetaboliteCHEBI:57742 (ChEBI)
hemiacetalsMetaboliteCHEBI:5653 (ChEBI)
histamineMetaboliteCHEBI:58432 (ChEBI)
homocysteineMetaboliteCHEBI:58199 (ChEBI)
hypotaurineMetaboliteCHEBI:57853 (ChEBI)
imidazole-4-acetaldehydeMetaboliteCHEBI:27398 (ChEBI)
mTORC1 complexComplexCPX-503 (Complex Portal)
mTORC2 complexComplexCPX-4402 (Complex Portal)
melatoninMetaboliteCHEBI:16796 (ChEBI)
moco sulfide Metabolite82685 (ChEBI)
nicotinate D-ribonucleotide(2−)MetaboliteCHEBI:57502 (ChEBI)
noladin etherMetaboliteCHEBI:75913 (ChEBI)
norepinephrineMetaboliteCHEBI:72587 (ChEBI)
oxytocinMetaboliteCHEBI:7872 (ChEBI)
phenylethylamine

2-phenylethylamine PEA

MetaboliteCHEBI:225237 (ChEBI)
pyridoxalMetaboliteCHEBI:17310 (ChEBI)
pyridoxamineMetaboliteCHEBI:57761 (ChEBI)
pyridoxine 5'-phosphateMetaboliteCHEBI:58589 (ChEBI)
q-BH2MetaboliteCHEBI:43029 (ChEBI)
q-H2BPTMetaboliteCHEBI:43120 (ChEBI)
rs1023159Rnars1023159 (dbSNP)
rs1051266Rnars1051266 (dbSNP)
rs1051312Rnars1051312 (dbSNP)
rs10521432Rnars10521432 (dbSNP)
rs10879352Rnars10879352 (dbSNP)
rs11178997Rnars11178997 (dbSNP)
rs1137070Rnars1137070 (dbSNP)
rs121913223Rnars121913223 (dbSNP)
rs12843268Rnars12843268 (dbSNP)
rs12843533Rnars12843533 (dbSNP)
rs13189021Rna
rs1352250Rnars1352250 (dbSNP)
rs1390938Rnars1390938 (dbSNP)
rs1406946Rnars1406946 (dbSNP)
rs1465107Rnars1465107 (dbSNP)
rs1487275Rnars1487275 (dbSNP)
rs151257822GeneProductrs151257822 (dbSNP)
rs1532268Rnars1532268 (dbSNP)
rs1543334Rnars1543334 (dbSNP)
rs165599Rnars165599 (dbSNP)
rs165774Rnars165774 (dbSNP)
rs1667627Rnars1950902 (dbSNP)
rs1672717Rnars1672717 (dbSNP)
rs167771Rnars167771 (dbSNP)
rs16976358Rnars16976358 (dbSNP)
rs174696Rnars174696 (dbSNP)
rs1799836Rnars1799836 (dbSNP)
rs1799971Rnars1799971 (dbSNP)
rs1800544Rnars1800544 (dbSNP)
rs1800955Rnars1800955 (dbSNP)
rs1801131Rnars1801131 (dbSNP)
rs1801133Rnars1801133 (dbSNP)
rs1801198Rnars1801198 (dbSNP)
rs1801394Rnars1801394 (dbSNP)
rs1805087Rnars1805087 (dbSNP)
rs1923886Rnars1923886 (dbSNP)
rs1950902Rnars1950902 (dbSNP)
rs1979277Rnars1979277 (dbSNP)
rs2056202Rnars2056202 (dbSNP)
rs2071010Rnars2071010 (dbSNP)
rs2088102Rnars2088102 (dbSNP)
rs2129575Rnars2129575 (dbSNP) rs2129575
rs2236225Rnars2236225 (dbSNP)
rs2242446Rnars2242446 (dbSNP)
rs2254298GeneProductrs2254298 (dbSNP)
rs2268491GeneProductrs2268491 (dbSNP)
rs2270637Rnars2270637 (dbSNP)
rs2270641Rnars2270641 (dbSNP)
rs2279709Rnars2279709 (dbSNP)
rs2292813Rnars2292813 (dbSNP)
rs2298444Rnars2298444 (dbSNP)
rs237887GeneProductrs237887 (dbSNP)
rs237889GeneProductrs237889 (dbSNP)
rs237897GeneProductrs237897 (dbSNP)
rs237902GeneProductrs237902 (dbSNP)
rs2518352Rnars2518352 (dbSNP)
rs251915Rnars251915 (dbSNP)
rs2550936Rna
rs265981Rnars265981 (dbSNP)
rs2710102Rnars2710102 (dbSNP)
rs28386840Rnars28386840 (dbSNP)
rs2934966Rnars2934966 (dbSNP)
rs3027400Rnars3027400 (dbSNP)
rs3027407Rnars3027407 (dbSNP)
rs35062132GeneProductrs35062132 (dbSNP)
rs36017Rnars36017 (dbSNP)
rs362204Rnars362204 (dbSNP)
rs3733890Rnars3733890 (dbSNP)
rs3746544Rnars3746544 (dbSNP)
rs3782025Rnars3782025 (dbSNP)
rs3785143Rnars3785143 (dbSNP)
rs3785157Rnars3785157 (dbSNP)
rs3813034Rnars3813034 (dbSNP)
rs3819331Rnars3819331 (dbSNP)
rs4130047Rnars4130047 (dbSNP)
rs4291Rnars4291 (dbSNP)
rs4343Rnars4343 (dbSNP)
rs4446909Rnars4446909 (dbSNP)
rs4532Rnars4532 (dbSNP)
rs4570625Rnars4570625 (dbSNP)
rs4633Rnars4633 (dbSNP)
rs4680Rnars4680 (dbSNP)
rs4818RnaRS4818 (dbSNP)
rs4846049Rnars4846049 (dbSNP)
rs53576GeneProductrs53576 (dbSNP)
rs5569Rnars5569 (dbSNP)
rs5905512Rnars5905512 (dbSNP)
rs590551Rnars590551 (dbSNP)
rs5906883 Rnars5906883  (dbSNP)
rs594445Rnars594445 (dbSNP)
rs5949028Rnars5949028 (dbSNP)
rs5989681Rnars5989681 (dbSNP)
rs602618Rnars602618 (dbSNP)
rs6189Rnars6189 (dbSNP)
rs6198Rnars6198 (dbSNP)
rs6267RnaRS6267 (dbSNP)
rs6269Rnars6269 (dbSNP)
rs6280Rnars6280 (dbSNP)
rs6296Rnars6296 (dbSNP)
rs6318Rnars6318 (dbSNP)
rs6323Rnars5906883 (dbSNP)
rs651646 Rnars651646  (dbSNP)
rs6561333Rnars6561333 (dbSNP)
rs6582071Rnars6582071 (dbSNP)
rs6651806Rnars6651806 (dbSNP)
rs6746030Rnars6746030 (dbSNP)
rs686Rnars686 (dbSNP)
rs70991108Rnars70991108 (dbSNP)
rs737865Rnars737865 (dbSNP)
rs740601Rnars740601 (dbSNP)
rs7632287GeneProductrs7632287 (dbSNP)
rs7794745Rnars7794745 (dbSNP)
rs779867Rnars779867 (dbSNP)
rs7997012Rnars7997012 (dbSNP)
rs876657421Rnars876657421 (dbSNP)
rs908670Rnars908670 (dbSNP)
rs916455Rnars916455 (dbSNP)
sepiapterinMetaboliteCHEBI:16095 (ChEBI)
serineMetaboliteQ82980657 (Wikidata)
serotoninMetaboliteCHEBI:350546 (ChEBI)
succinate MetaboliteQ213050 (Wikidata)
succinic semialdehydeMetaboliteCHEBI:57706 (ChEBI)
taurineMetaboliteCHEBI:507393 (ChEBI)
tyramineMetaboliteCHEBI:327995 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5420"
Personal tools