Glucocorticoid and mineralcorticoid metabolism (Mus musculus)

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UrocortisonePregnane 3,20-dione5b-Pregnane-3,20-dione3a,11b,21-Trihydroxy-20-Oxo-5b-Pregnan-18-al11-DeoxycorticosteroneGlucuronides*11-DeoxycortisolUrocortisol11b,17a 21-Trihydroxy-5b*Glucocorticoids11b, 21-Dihydroxy-3,20-5b-Pregnan-18-al3B-OH-delta-steroid Dh*3Progesterone degradationCortoloneHsd3b217alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trioneHsd3b1Cyp17a1Akr1c21CortisolCorticosteroneCyp11a1Cyp11b218-Hydroxycorticosterone3alpha-Hydroxy-5beta-pregnane-20-one3a-Hydroxysteroid DhHsd11b2Hsd3b6CortisolCholesterol biosynthesisCyp17a1AldosteroneHsd3b4ProgesteroneAndrogen synthesisand metabolismCortisonePregnenoloneHsd11b1Cyp21a1Steroid hormonesignalingHsd3b13-Oxo-5b-Steroid DhHsd3b3Cyp11b2MetaboliteHsd3b117-a-Hydroxyprogesterone17a-HydroxypregnenoloneCortisone beta-reductaseHsd3b5PregnanediolCholesterol20b-Hydroxysteroid Dh(R)20-hydroxysteroid Dh


Description

Pathway will be compared to Human version when curated, followed by homology conversion.

Comments

GenMAPP remarks 
Adapted from http://au.expasy.org/tools/pathways/

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
128039view21:32, 21 January 2024EweitzConnect interactions, refine to mim-catalysis
128038view20:32, 21 January 2024EweitzUpgrade pathway representations
118582view13:40, 28 May 2021EweitzModified title
114020view15:19, 17 December 2020NhungPConnecting lines
112996view15:18, 29 October 2020DeSlModified description
112995view15:16, 29 October 2020DeSlChanged title, removed structural drawings
106899view13:37, 17 September 2019MaintBotHMDB identifier normalization
71740view20:18, 17 October 2013MaintBotAutomated update of data sources
71325view17:17, 17 October 2013MaintBotAutomated update of data sources
69138view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67283view10:31, 26 June 2013Christine ChichesterOntology Term : 'C21-steroid hormone biosynthetic pathway' added !
62838view04:59, 3 May 2013MaintBotUpdated UniProt data source
41327view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
33388view14:43, 30 November 2009MaintBotRemoved group label
32963view21:54, 28 September 2009MaintBotPeriodical save, work in progress
32962view21:23, 28 September 2009MaintBotAdded metabolites and connectors
32961view21:10, 28 September 2009MaintBotadded metabolites and connectors
32960view21:05, 28 September 2009MaintBotPeriodical save, work in progress
32959view20:55, 28 September 2009MaintBotPeriodical save, work in progress
21720view11:32, 14 November 2008MaintBot[[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:WP495]]: Moved to stable identifier
8080view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Glucocorticoid Mineralocorticoid Metabolism]] moved to [[Pathway:Mus musculus:Glucocorticoid Mineralocorticoid Metabolism]]: Renaming species
7662view16:08, 18 December 2007MaintBotfixed category names
7361view12:42, 4 November 2007MaintBotAdded categories to GPML
7108view13:20, 10 October 2007MichielSpecify description
7107view13:19, 10 October 2007MichielSpecify description
7106view13:17, 10 October 2007Michieltest
7105view13:15, 10 October 2007Michieltest
7101view12:57, 10 October 2007MichielTest
19472view22:19, 22 May 2007M.Liebermangpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]
6450view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:Glucocorticoid_Mineralocorticoid_Metabolism]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(R)20-hydroxysteroid DhGeneProduct
17-a-HydroxyprogesteroneMetabolite
17a-HydroxypregnenoloneMetaboliteHMDB0000363 (HMDB)
17alpha,21-Dihydroxy-5beta-pregnane-3,11,20-trioneMetaboliteHMDB0006758 (HMDB)
18-HydroxycorticosteroneMetaboliteHMDB0000319 (HMDB)
20b-Hydroxysteroid DhGeneProduct
3-Oxo-5b-Steroid DhGeneProduct
3a-Hydroxysteroid DhGeneProduct
3alpha-Hydroxy-5beta-pregnane-20-oneMetaboliteHMDB0006759 (HMDB)
Akr1c21GeneProduct77337 (Entrez Gene) SP, mouse EST: AW611181, rat SP: DIDH RAT
AldosteroneMetaboliteHMDB0000037 (HMDB)
Androgen synthesis

and metabolism

Pathway
Cholesterol biosynthesisPathwayWP103 (WikiPathways)
CholesterolMetaboliteHMDB0000067 (HMDB)
CorticosteroneMetaboliteHMDB0001547 (HMDB)
CortisolMetaboliteHMDB0000063 (HMDB)
Cortisone beta-reductaseGeneProduct
CortisoneMetaboliteHMDB0002802 (HMDB)
CortoloneMetaboliteHMDB0003128 (HMDB)
Cyp11a1GeneProduct13070 (Entrez Gene)
Cyp11b2GeneProduct13072 (Entrez Gene) EC number: 1.14.15.5
Cyp17a1GeneProduct13074 (Entrez Gene)
Cyp21a1GeneProduct13079 (Entrez Gene)
Hsd11b1GeneProduct15483 (Entrez Gene)
Hsd11b2GeneProduct15484 (Entrez Gene)
Hsd3b1GeneProduct15492 (Entrez Gene)
Hsd3b2GeneProduct15493 (Entrez Gene)
Hsd3b3GeneProduct15494 (Entrez Gene)
Hsd3b4GeneProduct15495 (Entrez Gene)
Hsd3b5GeneProduct15496 (Entrez Gene)
Hsd3b6GeneProduct15497 (Entrez Gene)
MetaboliteMetabolite
PregnanediolMetaboliteHMDB0004025 (HMDB)
PregnenoloneMetaboliteHMDB0000253 (HMDB)
Progesterone degradationPathway
ProgesteroneMetaboliteHMDB0001830 (HMDB)
Steroid hormone signalingPathway

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP495"
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