IL10 anti-inflammatory signaling (Homo sapiens)

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1, 2Macrophage cytoplasmNucleusInflammatory cytokinegenesLPS induced pathwayDNA+JAK/STAT inducedgenesBLVRBCOHemeSTAT2IL10RBTNFHMOX1BiliverdinSTAT3BLVRAIL10BilirubinSTAT1JAK1p38 MAPK pathwayIL6IL1AIL10RAHMOX1DNA


Description

IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production.

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Ontology Terms

 

Bibliography

  1. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, Tripathy SP, Suar M, Pandey A, Gandotra S, Prasad TS, Shankar S; ''A network map of Interleukin-10 signaling pathway.''; J Cell Commun Signal, 2016 PubMed Europe PMC Scholia
  2. Hutchins AP, Diez D, Miranda-Saavedra D; ''The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges.''; Brief Funct Genomics, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129721view01:33, 22 May 2024EweitzModified title
128412view13:01, 4 February 2024EweitzRefine cell type name, expand uncommon abbreviation, tailor pathway node heights
128411view12:54, 4 February 2024EweitzOntology Term : 'macrophage' added !
125654view15:55, 6 March 2023DeSlOntology Term : 'Interleukin-10 signaling pathway' added !
125652view15:53, 6 March 2023DeSlConnected unconnected line
125634view02:03, 6 March 2023AlexanderPicoModified description
123501view04:58, 29 July 2022EgonwMade a pathway clickable
117759view12:53, 22 May 2021EweitzModified title
102692view15:42, 19 January 2019FehrhartOntology Term : 'signaling pathway' added !
102664view12:53, 16 January 2019LaurentModified description
102649view09:19, 16 January 2019LaurentUpdated literature
102648view09:12, 16 January 2019LaurentAdded metabolite and pathway nodes. Fixed interactions
102621view13:54, 14 January 2019LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BLVRAGeneProduct644 (Entrez Gene)
BLVRBGeneProduct645 (Entrez Gene)
BilirubinMetaboliteQ104219 (Wikidata)
BiliverdinMetaboliteQ422964 (Wikidata)
COMetaboliteQ2025 (Wikidata)
HMOX1GeneProduct3162 (Entrez Gene)
HemeMetaboliteQ189621 (Wikidata)
IL10GeneProduct3586 (Entrez Gene)
IL10RAGeneProduct3587 (Entrez Gene)
IL10RBGeneProduct3588 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT2GeneProduct6773 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TNFGeneProduct7214 (Entrez Gene)
p38 MAPK pathwayPathwayWP400 (WikiPathways)

Annotated Interactions

No annotated interactions

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