Cell lineage map for neuronal differentiation (Homo sapiens)

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1-5Stem cellSOX17DLG1NESCACNG2FGF4GRIN2BSHANK3HES3SOX2CD34SOX9FUT4UNC13ATHCASKFEVSLC6A4FOXA2LEF1CHATGLRA2MSX2HOMER2HOMER3HES5FOXA2AP2A1TPH1RIMBP2TUBB3HNF4ALIN7AHTR5ANLGN1MBPTNCHES1PCLOSLC1A3GATA6SLC6A9S100BERC1POU5F1LHX1SLC1A2DPPA3ERASSLC17A7GLRA4FABP7AQP4SLC6A3GLRBKRT15SOX10SLC6A2FOXD3GLRA1RIMS2SNAP25MOGALDH1L1GLSSYPADRA2BCD24ROBO1DLG3GPHNITGB1TWIST1PPFIA1MSX1CDH2SNAI2ACHEDLG4NGFRDLL1CDH1LMX1BKLF4ITGA6TBR1TPM1GABBR1TBXTTWIST2FBXO15ADRA2AGLULNEFMESRRBPAX3CNPHTR1AGATA4PECAM1EVX1BSNNANOGGABBR2AP2A2SLC6A5ADRA2CSLC18A3MIXL1NEFLDLG2NOTCH1BMP4SLC6A1GLRA3KCNJ6GAD2PAX6SNAI1CSPG4HOMER1RBFOX3NR4A2GRIN1GAD1SLC17A6MAP2SHANK1DCXCLDN11NODALOLIG2DPPA2ZFP42GFAPEctodermMesodermEndodermNeural progenitorNon-neural ectodermNeural crestImmature neuronAstrocyteOligodendrocyteMature neuronPre-synapsePost-synapseGlutamatergicGABAergicGlycinergicCholinergicDopaminergicNoradrenergicSerotonergic


Description

This cell lineage map consists of a set of cell types emerging during neural differentiation.

A selection of cell type-specific markers was made based on literature (e.g. Beccari et al., 2018, https://doi.org/10.1038/s41586-018-0578-0; Kügler et al., 2010, https://doi.org/10.14573/altex.2010.1.16; Spangler et al., 2018, https://doi.org/10.1016/j.scr.2018.07.022; Tao and Zhang, 2016, https://doi.org/10.1016/j.stem.2016.10.015) to distinguish these different cell types. This map was published in: Victoria de Leeuw et al., 2020, NeuroToxicology 76, 1-9. https://doi.org/10.1016/j.neuro.2019.09.014.

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Quality Tags

Ontology Terms

 

Bibliography

  1. ''Markers of murine embryonic and neural stem cells, neurons and astrocytes: Reference points for developmental neurotoxicity testing ''; , DOI Scholia
  2. ''Neural Subtype Specification from Human Pluripotent Stem Cells''; , DOI Scholia
  3. ''Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map''; , DOI Scholia
  4. ''A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo''; , DOI Scholia
  5. ''Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids''; , DOI Scholia

History

View all...
CompareRevisionActionTimeUserComment
128450view18:13, 4 February 2024EweitzOntology Term : 'serotonergic neuron' added !
128449view18:13, 4 February 2024EweitzOntology Term : 'cholinergic neuron' added !
128448view18:13, 4 February 2024EweitzOntology Term : 'GABAergic neuron' added !
128447view18:12, 4 February 2024EweitzOntology Term : 'noradrenergic neuron' added !
128446view18:12, 4 February 2024EweitzOntology Term : 'dopaminergic neuron' added !
128445view18:11, 4 February 2024EweitzOntology Term : 'glutamatergic neuron' added !
128444view18:11, 4 February 2024EweitzOntology Term : 'oligodendrocyte' added !
128443view18:10, 4 February 2024EweitzOntology Term : 'astrocyte' added !
128442view18:10, 4 February 2024EweitzOntology Term : 'neural crest cell' added !
128441view18:10, 4 February 2024EweitzOntology Term : 'neural progenitor cell' added !
128440view18:09, 4 February 2024EweitzOntology Term : 'endodermal cell' added !
128439view18:09, 4 February 2024EweitzOntology Term : 'mesodermal cell' added !
128438view18:09, 4 February 2024EweitzOntology Term : 'ectodermal cell' added !
128437view18:09, 4 February 2024EweitzOntology Term : 'stem cell' added !
128436view18:08, 4 February 2024EweitzStandardize case
127426view10:10, 1 October 2023EgonwAdded the titles of the DOI articles
127425view10:07, 1 October 2023EgonwAdded the DOIs as literature references (to be completed on classic)
127420view09:53, 1 October 2023EgonwOntology Term : 'regulatory pathway' added !
127419view09:53, 1 October 2023EgonwOntology Term : 'neuron' added !
127321view08:52, 14 September 2023PenningsModified description
127318view08:47, 14 September 2023PenningsNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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Annotated Interactions

No annotated interactions

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