Arsenic liver toxicity pathway (Homo sapiens)

Revision as of 09:48, 27 March 2024 by Mkutmon (Talk | contribs)

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Description

This is an adverse outcome pathway of arsenic toxicity on liver including key processes leading to arsenic induced liver cancer.

View approved pathways at the new wikipathways.org.

Angrish MM, Allard P, McCullough SD, Druwe IL, Helbling Chadwick L, Hines E, Chorley BN; ''Epigenetic Applications in Adverse Outcome Pathways and Environmental Risk Evaluation.''; Environ Health Perspect, 2018 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
129377	view	09:48, 27 March 2024	Mkutmon	Ontology Term : 'disease pathway' added !
128630	view	03:16, 17 February 2024	Eweitz	Economize layout, standardize case
128617	view	00:05, 17 February 2024	Eweitz	Ontology Term : 'hepatocyte' added !
128616	view	00:05, 17 February 2024	Eweitz	Ontology Term : 'liver cancer' added !
128615	view	00:04, 17 February 2024	Eweitz	Modified title
128606	view	20:25, 15 February 2024	Marvin M2	Added reference
122969	view	12:43, 5 June 2022	ZDLech
122896	view	12:00, 30 May 2022	ZDLech	Changed ID for pathway: Arsenic carcinogenesis - reactive oxygen species
122862	view	17:14, 25 May 2022	ZDLech	Added Key Event 155
122694	view	13:23, 3 May 2022	ZDLech	Pathway change under KE1487
122660	view	15:03, 27 April 2022	ZDLech	Removed arsenic node add added arrows to the interactions
122656	view	13:16, 26 April 2022	ZDLech	New pathway

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Name	Type	Database reference
Arsenic carcinogenesis - reactive oxygen species	Pathway	WP5233 (WikiPathways)
Cell cycle	Pathway	WP179 (WikiPathways)
DNA damage response	Pathway	WP707 (WikiPathways)
KE1194: Increased DNA damage	Key Event	1194 (AOP-Wiki KE)
KE1395: Liver cancer	Key Event	1395 (AOP-Wiki KE)
KE1487:Binding, Thiol/seleno-proteins involved in protection against oxidative stress	Key Event	1487 (AOP-Wiki KE)
KE155: Inadequate DNA repair	Key Event	155 (AOP-Wiki KE)
KE1894: Chronic low grade systemic inflammation	Key Event	1894 (AOP-Wiki KE)
KE1940: Up-regulation of reactive oxygen species	Key Event	1940 (AOP-Wiki KE)
KE1969: Increased oxidative stress	Key Event	1969 (AOP-Wiki KE)
KE716: Increase, cell proliferation (hepatocytes)	Key Event	716 (AOP-Wiki KE)
NRF2 pathway	Pathway	WP2884 (WikiPathways)
Oxidative damage response	Pathway	WP3941 (WikiPathways)
TNF-alpha signaling pathway	Pathway	WP231 (WikiPathways)

No annotated interactions