Axon guidance (Homo sapiens)

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Neuron1, 2Regulation ofactin cytoskeletonMAPK signalingDCCLRRC4CCFL1RHOAPLXNA1NRP1L1CAMSEMA3AFESFYNCDK5PLCG1DPYSL5DPYSL2PLXNB2SEMA4FSEMA5BSEMA6CSEMA7AMETPLXNC1PTK2ITGB1PTK2RAC1PAK4RRASRND1ARHGEF12RHOASRCRAF1MAPK1SHHPTCH1SMOBOCSMOPRKCAILKWNT5AFZD3RYKTRPC1CAMK2AWNT4UNC5DFZD3PIK3CAPDPK1PRKCZPARD3PARD6ATRPC1PPP3CANTN1BMPR2BMPR1BBMP7GDF7SHHCFL1LIMK1CFL1NTN3CDC42NCK2CDC42GSK3BFYNGSK3BNTN4DCCLRRC4PTK2NCK1PTPN11NFATC2PAK4SRCFYNRHOATRPC1ROCK1RAC1ABLIM3NEO1LRIG2NTNG1RGMAPTK2ARHGEF12RHOAROCK1MYL12BEPHA2EPHB1ABL1NTNG2RASA1NGEFENAHHRASMAPK1RAC1CDC42RHOAROCK1EFNA1EFNB1CXCR4CXCR4CXCL12PAK4RASA1FYNNCK2PTK2RGS3GNAI1PPP3CAGNAI1ROBO2ROBO1SLIT1SLIT2SLIT3ROBO3ABL1ENAHSRGAP2PAK4RAC1RAC1PAK4RHODRND1LIMK1Ca2+Ca2+Ca2+Ca2+Axon repulsionAttractionTranscriptionLegendAxon outgrowthWnt signalingRegulation of actin cytoskeletonCytokine-cytokinereceptor interactionRepulsionAttractionAxon attractionMicrotubulereorganizationRegulation ofactin cytoskeletonRegulation of actin cytoskeletonMAPK signalingDCCPhosphorylationDephosphorylation


Description

Axon guidance forms neuronal networks. Axons are guided by factors including netrins, ephrins, Slits, and semaphorins. These guidance cues interact with growth cone receptors, and downstream signal transduction pathways converge onto Rho GTPases which change in cytoskeletal organization. Those cytoskeletal changes determine which way the growth cone will turn. This pathway is derived from https://www.kegg.jp/entry/map04360.

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Ontology Terms

 

Bibliography

  1. Goto-Silva L, Martins M, Murillo JR, Souza LRQ, Vitória G, Oliveira JT, Nascimento JM, Loiola EC, Nogueira FCS, Domont GB, Guimarães MZP, Tovar-Moll F, Rehen SK, Junqueira M; ''Quantitative profiling of axonal guidance proteins during the differentiation of human neurospheres.''; Biochim Biophys Acta Proteins Proteom, 2021 PubMed Europe PMC Scholia
  2. ''''; https://www.kegg.jp/entry/map04360,

History

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CompareRevisionActionTimeUserComment
130759view03:12, 30 May 2024EweitzRefine link to new WikiPathway
129834view00:34, 23 May 2024EweitzLink "Regulation of actin cytoskeleton" to WP pathway
129655view23:10, 21 May 2024EweitzImprove node alignment
129654view23:09, 21 May 2024EweitzEconomize layout
129648view22:49, 21 May 2024EweitzImprove node alignment, economize layout
129647view22:45, 21 May 2024EweitzEconomize layout
129617view02:54, 19 May 2024EweitzImprove connectivity, refine colors, economize layout
129605view19:33, 18 May 2024EweitzEconomize layout
129604view17:38, 18 May 2024EweitzColor terminal interactions
129603view17:18, 18 May 2024EweitzImprove connectivity, per KEGG source
129602view15:59, 18 May 2024EweitzModified description
129601view15:55, 18 May 2024EweitzModified description
129600view15:33, 18 May 2024EweitzEconomize layout
129595view00:47, 17 May 2024EweitzSpecify most phosphorylation interactions, add legend
129592view12:42, 16 May 2024EweitzEconomize layout
129591view12:18, 16 May 2024EweitzRefine content per KEGG source, economize layout
129589view03:30, 16 May 2024EweitzReduce overlapping interactions, economize layout
129588view03:19, 16 May 2024EweitzEconomize layout
129587view03:08, 16 May 2024EweitzFinish diagram rotation / tranposition for easier viewing
129586view01:07, 16 May 2024EweitzContinue diagram rotation
129585view00:48, 16 May 2024EweitzContinue diagram rotation, refine alignments
129584view23:54, 15 May 2024EweitzBegin graphical rotation, for better readability on desktop viewports
129580view21:18, 14 May 2024EweitzEconomize layout
129573view01:15, 14 May 2024EweitzEconomize layout
129572view22:44, 13 May 2024EweitzEconomize layout
129571view22:33, 13 May 2024EweitzEconomize layout
129446view15:59, 20 April 2024EweitzModified title
129395view17:39, 8 April 2024Khanspersadded KEGG pathway as reference
129394view17:38, 8 April 2024KhanspersOntology Term : 'signaling pathway pertinent to the brain and nervous system' added !
129393view17:37, 8 April 2024KhanspersOntology Term : 'neuron' added !
129392view17:34, 8 April 2024Khanspersadded xrefs, updated interactions, removed redundant and empty nodes
129389view00:36, 6 April 2024Khanspersupdated interactions to elbows, changed pathway nodes to labels
129388view00:21, 6 April 2024Khanspersremoved fill color for nodes and cell shapes, updated pathway and metabolite nodes
124308view16:09, 12 October 2022LLadeiraModified title
124307view16:06, 12 October 2022LLadeiraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1ProteinENSG00000097007 (Ensembl)
ABLIM3ProteinO94929 (Uniprot-TrEMBL)
ARHGEF12ProteinNM_015313 (RefSeq)
BMP7Protein1074 (HGNC Accession number)
BMPR1BProtein658 (Entrez Gene)
BMPR2Protein659 (Entrez Gene)
BOCProtein91653 (Entrez Gene)
CAMK2AProtein1460 (HGNC Accession number)
CDC42Protein998 (Entrez Gene)
CDK5ProteinCDK5 (HGNC)
CFL1ProteinENSG00000172757 (Ensembl)
CXCL12ProteinP48061 (Uniprot-TrEMBL)
CXCR4ProteinNM_001008540 (RefSeq)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cytokine-cytokine receptor interactionPathwayhsa04060 (KEGG Pathway)
DCCProteinNM_005215 (RefSeq)
DPYSL2ProteinNM_001386 (RefSeq)
DPYSL5ProteinQ9BPU6 (Uniprot-TrEMBL)
EFNA1Protein1942 (Entrez Gene)
EFNB1ProteinP98172 (Uniprot-TrEMBL)
ENAHProteinNM_018212 (RefSeq)
EPHA2ProteinEPHA2 (HGNC)
EPHB1ProteinEPHB1 (HGNC)
FESProteinNM_002005 (RefSeq)
FYNProteinFYN (HGNC)
FZD3ProteinFZD3 (HGNC)
GDF7ProteinGDF7 (HGNC)
GNAI1ProteinNM_002069 (RefSeq)
GSK3BProteinGSK3B (HGNC)
HRASProteinENSG00000174775 (Ensembl)
ILKProteinENSG00000166333 (Ensembl)
ITGB1ProteinNM_002211 (RefSeq)
L1CAMProteinP32004 (Uniprot-TrEMBL)
LIMK1Protein6613 (HGNC Accession number)
LRIG2Protein9860 (Entrez Gene)
LRRC4Protein15586 (HGNC Accession number)
LRRC4CProteinENSG00000148948 (Ensembl)
MAPK signalingPathwayhsa04010 (KEGG Pathway)
MAPK1ProteinENSG00000100030 (Ensembl)
METProteinMET (HGNC)
MYL12BProtein103910 (Entrez Gene)
NCK1ProteinENSG00000158092 (Ensembl)
NCK2Protein7665 (HGNC Accession number)
NEO1Protein7754 (HGNC Accession number)
NFATC2Protein7776 (HGNC Accession number)
NGEFProteinQ8N5V2 (Uniprot-TrEMBL)
NRP1Protein8829 (Entrez Gene)
NTN1Protein8029 (HGNC Accession number)
NTN3Protein4917 (Entrez Gene)
NTN4Protein59277 (Entrez Gene)
NTNG1Protein23319 (HGNC Accession number)
NTNG2ProteinNM_032536 (RefSeq)
PAK4Protein16059 (HGNC Accession number)
PARD3ProteinPARD3 (HGNC)
PARD6AProteinENSG00000102981 (Ensembl)
PDPK1ProteinENSG00000140992 (Ensembl)
PIK3CAProtein8975 (HGNC Accession number)
PLCG1Protein9065 (HGNC Accession number)
PLXNA1ProteinENSG00000114554 (Ensembl)
PLXNB2Protein9104 (HGNC Accession number)
PLXNC1Protein9106 (HGNC Accession number)
PPP3CAProtein9314 (HGNC Accession number)
PRKCAProteinPRKCA (HGNC)
PRKCZProtein5590 (Entrez Gene)
PTCH1ProteinNM_000264 (RefSeq)
PTK2Protein9611 (HGNC Accession number)
PTPN11Protein9644 (HGNC Accession number)
RAC1Protein5879 (Entrez Gene)
RAF1ProteinENSG00000132155 (Ensembl)
RASA1ProteinNM_002890 (RefSeq)
RGMAProtein56963 (Entrez Gene)
RGS3Protein9999 (HGNC Accession number)
RHOAProtein667 (HGNC Accession number)
RHODProteinO00212 (Uniprot-TrEMBL)
RND1Protein18314 (HGNC Accession number)
ROBO1ProteinQ9Y6N7 (Uniprot-TrEMBL)
ROBO2ProteinNM_001128929 (RefSeq)
ROBO3ProteinNM_022370 (RefSeq)
ROCK1Protein6093 (Entrez Gene)
RRASProteinRRAS (HGNC)
RYKProteinENSG00000163785 (Ensembl)
Regulation of actin cytoskeletonPathwayhsa04810 (KEGG Pathway)
Regulation of actin cytoskeletonPathwayhsa04810 (KEGG Pathway)
Regulation of actin cytoskeletonPathwayhsa04810 (KEGG Pathway)
SEMA3AProteinNM_006080 (RefSeq)
SEMA4FProtein10734 (HGNC Accession number)
SEMA5BProtein54437 (Entrez Gene)
SEMA6CProteinENSG00000143434 (Ensembl)
SEMA7AProtein8482 (Entrez Gene)
SHHProteinQ15465 (Uniprot-TrEMBL)
SLIT1ProteinSLIT1 (HGNC)
SLIT2Protein9353 (Entrez Gene)
SLIT3ProteinSLIT3 (HGNC)
SMOProtein11119 (HGNC Accession number)
SRCProteinP12931 (Uniprot-TrEMBL)
SRGAP2ProteinNM_015326 (RefSeq)
TRPC1ProteinTRPC1 (HGNC)
UNC5DProteinQ6UXZ4 (Uniprot-TrEMBL)
WNT4ProteinENSG00000162552 (Ensembl)
WNT5AProteinWNT5A (HGNC)
Wnt signalingPathwayhsa04310 (KEGG Pathway)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5289"
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