Urea cycle and metabolism of amino groups (Homo sapiens)

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Purine metabolismN-MethylhydantoinC03406N-Acetyl-L-glutamateN2-Acetyl-L-ornithineCO2N-Acetyl-L-glutamateAla and aspartate metabolismPhosphoguanidinoacetateFumarateCarbamoylGuanidinoacetateFormateD-Arg and D-ornithine metabolismNitrogen metabolismPro metabolismGlutamate metabolismPyrimidine metabolismN-CarbamoylsarcosineL-Aspartate5-semialdehyde(S)-1-Pyrroline-5-carboxylateCitrate cycle (TCA cycle)Urea-1-carboxylateArginine metabolismNH3Amino acid metabolismN-Acetyl-glutamateL-Glutamylcreatine-P3.5.1.59PYCRLNAGSSarcosineCPS1ARG2FormaldehydeSRMSpermineASL6.3.4.63.5.3.3PYCR1GAMTUreaL-ProlineL-Citrulline1.2.1.383.5.1.542.6.1.11ALDH18A13.5.1.5ALDH18A13.5.4.212.7.3.11.5.99.1L-Ornithine1.2.1.462.6.1.693.5.2.10SpermidineASS2.3.1.35PutrescineOATACY1ODC1ArginineARG1GATM3.5.1.16GLUD1CreatineCKMOTCL-Glutamate-L-Glutamate3.5.2.142.7.2.8CKBSMSSMSCreatinine


Description

No description

Comments

GenMAPP notes 
Converted from rat to human using ortholog information. Link to original KEGG map: http://www.genome.ad.jp/dbget-bin/show pathway?rno00220
GenMAPP remarks 
Edited by Sebastien Burel

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : asparagine metabolic pathway
 

Bibliography

  1. Dahlman, Douglas L., Milan A. Berge.; ''Possible mechanisms for adverse effects of L-canavanine on insects.''; ACS Publications, 1986 DOI Scholia
  2. Seiler N; ''Ornithine aminotransferase, a potential target for the treatment of hyperammonemias.''; Curr Drug Targets, 2000 PubMed Europe PMC Scholia
  3. Deuschle K, Funck D, Hellmann H, Däschner K, Binder S, Frommer WB; ''A nuclear gene encoding mitochondrial Delta-pyrroline-5-carboxylate dehydrogenase and its potential role in protection from proline toxicity.''; Plant J, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137470
Approved
view14:58, 2 March 2025EgonwModified description
119105view10:02, 17 June 2021FinterlyAdded DOI, removed duplicate PublicationXref and fixed BiopaxRef
114002view21:55, 16 December 2020EgonwTwo more pathways clickable
105850view23:15, 15 August 2019KhanspersModified description
103837view12:35, 10 April 2019IreneHemelAdded Uniprot IDs
103836view11:00, 10 April 2019IreneHemelChanged datanodes for enzymes from geneproduct to protein
96019view15:13, 15 February 2018Mkutmonremoved old pathways attributes
96018view15:13, 15 February 2018MkutmonModified description
95281view18:12, 29 November 2017DeSlChanged several graphical lines to directed interactions + added litertaure references for these.
94180view13:40, 25 August 2017DeSlAdded ID for L-Glutamyl
92933view09:00, 20 July 2017EgonwFixed to the correct CAS number: it had the number of creatine.
72142view10:02, 25 October 2013Mkutmonadded datasource to EC numbers
71261view21:34, 16 October 2013MaintBotAutomated update of data sources
71169view11:01, 11 October 2013Mkutmonfixed unconnected lines
68976view17:41, 8 July 2013MaintBotUpdated to 2013 gpml schema
45014view18:23, 6 October 2011KhanspersOntology Term : 'urea cycle pathway' added !
43586view14:08, 5 July 2011AdrienDefayadd database name for TCA
41149view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
38842view17:40, 24 September 2010Khanspers
38688view18:15, 23 September 2010KhanspersMore pathway links
38687view18:08, 23 September 2010KhanspersAdded pathway links and changed arrows and layout
38685view18:04, 23 September 2010KhanspersPeriodical save, work in progress
34435view18:15, 10 December 2009MaintBotAutomatic update of empty xrefs
32123view13:53, 14 August 2009MaintBotFixed group labels
21724view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Urea cycle and metabolism of amino groups KEGG]] moved to [[Pathway:WP497]]: Moved to stable identifier
13997view16:08, 20 May 2008Thomasconnected lines
13129view11:18, 17 May 2008MaintBotautomated metabolite conversion
8476view13:46, 7 January 2008MaintBot[[Pathway:Human:Urea cycle and metabolism of amino groups KEGG]] moved to [[Pathway:Homo sapiens:Urea cycle and metabolism of amino groups KEGG]]: Renaming species
7854view16:23, 18 December 2007MaintBotfixed category names
7413view12:42, 4 November 2007MaintBotAdded categories to GPML
6404view22:18, 22 May 2007L.M.Ferrantegpml file for [[Human:Urea_cycle_and_metabolism_of_amino_groups_KEGG]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
1.2.1.38GeneProduct1.2.1.38
1.2.1.46GeneProduct1.2.1.46
1.5.99.1GeneProduct1.5.99.1
2.3.1.35GeneProduct2.3.1.35
2.6.1.11GeneProduct2.6.1.11
2.6.1.69GeneProduct2.6.1.69
2.7.2.8GeneProduct2.7.2.8
2.7.3.1GeneProduct2.7.3.1
3.5.1.16GeneProduct3.5.1.16
3.5.1.5GeneProduct3.5.1.5
3.5.1.54GeneProduct3.5.1.54
3.5.1.59GeneProduct3.5.1.59
3.5.2.10GeneProduct3.5.2.10
3.5.2.14GeneProduct3.5.2.14
3.5.3.3GeneProduct3.5.3.3
3.5.4.21GeneProduct3.5.4.21
6.3.4.6GeneProduct6.3.4.6
ACY1GeneProduct95 (Entrez Gene)
ALDH18A1GeneProduct5832 (Entrez Gene)
ARG1GeneProduct383 (Entrez Gene)
ARG2GeneProduct384 (Entrez Gene)
ASLGeneProduct435 (Entrez Gene)
ASSGeneProduct445 (Entrez Gene)
Arginine74-79-3 (CAS) L-Arginine
CKBGeneProduct1152 (Entrez Gene)
CKMGeneProduct1158 (Entrez Gene)
CPS1GeneProduct1373 (Entrez Gene)
Creatine57-00-1 (CAS) Creatine
Creatinine60-27-5 (CAS) Creatinine
Formaldehyde50-00-0 (CAS) Formaldehyde
GAMTGeneProduct2593 (Entrez Gene)
GATMGeneProduct2628 (Entrez Gene)
GLUD1GeneProduct2746 (Entrez Gene)
L-Citrulline372-75-8 (CAS) L-Citrulline
L-Glutamate-56-86-0 (CAS)
L-Glutamate56-86-0 (CAS) L-Glutamate
L-Ornithine70-26-8 (CAS) L-Ornithine
L-Proline147-85-3 (CAS) L-Proline
NAGSGeneProduct162417 (Entrez Gene)
OATGeneProduct4942 (Entrez Gene)
ODC1GeneProduct4953 (Entrez Gene)
OTCGeneProduct5009 (Entrez Gene)
PYCR1GeneProduct5831 (Entrez Gene)
PYCRLGeneProduct65263 (Entrez Gene)
Putrescine110-60-1 (CAS) Putrescine
SMSGeneProduct6611 (Entrez Gene)
SRMGeneProduct6723 (Entrez Gene)
Sarcosine107-97-1 (CAS) Sarcosine
Spermidine124-20-9 (CAS) Spermidine
Spermine71-44-3 (CAS) Spermine
Urea57-13-6 (CAS) Urea
creatine-P57-00-1 (CAS) Phosphocreatine

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP497"
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