Oxidative stress in pulmonary tissue (Homo sapiens)

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1Cigarette smokeApoptosisKE3: Cell death and cycle arrestKE2: Inflammation and pro-fibrotic stateAO1: Idophatic pulmonary fibrosisKE1: Increased oxidative stressParticulate matterKE6: ER stressEmission from biomassfuel and combusitonNitrogen oxidesKE4: Mitrochondrial dysfucntionPollen grainsRelease of pro-inflammatory cytokinesAO2: COPDAO3: Acute respiratory distresssyndromeKE5: Collagen production and reduced ECMAO4: AsthmaProfibrotic pathwayOzoneMIE1: ROS production upregulationIndustrial smokeSenescenceROS damage pathwaySulphur oxidesCarbon monoxidePesticidesChemokine signalling pathway


Description

Adverse Outcome Pathway (AOP) for stressor induced increase in ROS production in pulmonary tissue.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sajal Chakraborti, Narasimham L. Parinandi, Rita Ghosh, Nirmal K. Gangul, Tapati Chakraborti; ''Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases''; Pubmed, 2019 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
135313view21:29, 16 August 2024KhanspersOntology Term : 'oxidative stress response pathway' added !
133233view07:50, 10 June 2024BurritacoEndogenous ROS production was deleted and lipid membrane oxidation was removed.
131847view15:11, 4 June 2024BurritacoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AO1: Idophatic pulmonary fibrosis1458 (Other)
AO2: COPD
AO3: Acute respiratory distress syndrome
AO4: Asthma
ApoptosisPathwayWP254 (WikiPathways)
Carbon monoxide
Chemokine signalling pathwayPathwayWP3929 (WikiPathways)
Cigarette smoke
Emission from biomass fuel and combusiton
Industrial smoke
KE1: Increased oxidative stress1392 (Other)
KE2: Inflammation and pro-fibrotic state 1497 (Other)
KE3: Cell death and cycle arrest
KE4: Mitrochondrial dysfucntion177 (Other)
KE5: Collagen production and reduced ECM
KE6: ER stress
MIE1: ROS production upregulation
Nitrogen oxides
Ozone
Particulate matter
Pesticides
Pollen grains
Profibrotic pathwayPathwayWP3624 (WikiPathways)
ROS damage pathwayPathwayWP5477 (WikiPathways)
Release of pro-inflammatory cytokinesPathwayWP530 (WikiPathways)
SenescencePathwayWP2902 (WikiPathways)
Sulphur oxides

Annotated Interactions

No annotated interactions

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