Monoamine transport (Homo sapiens)

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1221241828203324301, 6, 191862213243030151620322194, 27246241025241118, 3012162669103825, 19264192017, 29247, 9201515, 303107814, 21242312ExpressionLegendNucleusSynthesis TransportGene / proteinCell membraneBindingNegative transportNegative regulationProtein modificationSmall moleculeNegative expressionGolgiRegulationSTX1ATSC2HEPESRBL2AMPHSCAMP2SYN1ReserpineNoradrenalineAnisomycinPVRL2TNFSLC5A7FBXO32SLC6A2ITGB3SB 203580CDC25CNOS1ACHEDopamineEpinephrineDBHTDO24-Aminobutanoic acidTNFRSF11BCatecholamineAGTSLC6A3SerotoninTPH2Hemicholinium-3HRH3MAPK14TGFB1I1Phorbol esterSLC6A1IL1R1CitalopramUNC13BL-tryptophanADORA2ATHPPP2CBIL1BSLC6A4


Description

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  1. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  2. Volpicelli-Daley LA, Hrabovska A, Duysen EG, Ferguson SM, Blakely RD, Lockridge O, Levey AI; ''Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia
  3. Carneiro AM, Blakely RD; ''Serotonin-, protein kinase C-, and Hic-5-associated redistribution of the platelet serotonin transporter.''; J Biol Chem, 2006 PubMed Europe PMC Scholia
  4. Zhu CB, Hewlett WA, Feoktistov I, Biaggioni I, Blakely RD; ''Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  5. Hahn MK, Robertson D, Blakely RD; ''A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  6. Miner LH, Jedema HP, Moore FW, Blakely RD, Grace AA, Sesack SR; ''Chronic stress increases the plasmalemmal distribution of the norepinephrine transporter and the coexpression of tyrosine hydroxylase in norepinephrine axons in the prefrontal cortex.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  7. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  8. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  9. Williams JM, Owens WA, Turner GH, Saunders C, Dipace C, Blakely RD, France CP, Gore JC, Daws LC, Avison MJ, Galli A; ''Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine.''; PLoS Biol, 2007 PubMed Europe PMC Scholia
  10. Iwamoto H, Blakely RD, De Felice LJ; ''Na+, Cl-, and pH dependence of the human choline transporter (hCHT) in Xenopus oocytes: the proton inactivation hypothesis of hCHT in synaptic vesicles.''; J Neurosci, 2006 PubMed Europe PMC Scholia
  11. Liprando LA, Miner LH, Blakely RD, Lewis DA, Sesack SR; ''Ultrastructural interactions between terminals expressing the norepinephrine transporter and dopamine neurons in the rat and monkey ventral tegmental area.''; Synapse, 2004 PubMed Europe PMC Scholia
  12. Sung U, Apparsundaram S, Galli A, Kahlig KM, Savchenko V, Schroeter S, Quick MW, Blakely RD; ''A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity.''; J Neurosci, 2003 PubMed Europe PMC Scholia
  13. Carneiro AM, Cook EH, Murphy DL, Blakely RD; ''Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans.''; J Clin Invest, 2008 PubMed Europe PMC Scholia
  14. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  15. Jayanthi LD, Samuvel DJ, Blakely RD, Ramamoorthy S; ''Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  16. Carneiro AM, Airey DC, Thompson B, Zhu CB, Lu L, Chesler EJ, Erikson KM, Blakely RD; ''Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
  17. Hahn MK, Blakely RD; ''Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia
  18. Zhu CB, Carneiro AM, Dostmann WR, Hewlett WA, Blakely RD; ''p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  19. Miner LH, Schroeter S, Blakely RD, Sesack SR; ''Ultrastructural localization of the norepinephrine transporter in superficial and deep layers of the rat prelimbic prefrontal cortex and its spatial relationship to probable dopamine terminals.''; J Comp Neurol, 2003 PubMed Europe PMC Scholia
  20. Dipace C, Sung U, Binda F, Blakely RD, Galli A; ''Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
  21. Savchenko V, Sung U, Blakely RD; ''Cell surface trafficking of the antidepressant-sensitive norepinephrine transporter revealed with an ectodomain antibody.''; Mol Cell Neurosci, 2003 PubMed Europe PMC Scholia
  22. Sung U, Jennings JL, Link AJ, Blakely RD; ''Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  23. Mazei-Robison MS, Bowton E, Holy M, Schmudermaier M, Freissmuth M, Sitte HH, Galli A, Blakely RD; ''Anomalous dopamine release associated with a human dopamine transporter coding variant.''; J Neurosci, 2008 PubMed Europe PMC Scholia
  24. Zhu CB, Blakely RD, Hewlett WA; ''The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.''; Neuropsychopharmacology, 2006 PubMed Europe PMC Scholia
  25. Tamminga CA, Nemeroff CB, Blakely RD, Brady L, Carter CS, Davis KL, Dingledine R, Gorman JM, Grigoriadis DE, Henderson DC, B Innis RB, Killen J, Laughren TP, McDonald WM, M Murphy GM Jr, Paul SM, Rudorfer MV, Sausville E, Schatzberg AF, Scolnick EM, Suppes T; ''''; , PubMed Europe PMC Scholia
  26. Sung U, Blakely RD; ''Calcium-dependent interactions of the human norepinephrine transporter with syntaxin 1A.''; Mol Cell Neurosci, 2007 PubMed Europe PMC Scholia
  27. Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD; ''Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase.''; Proc Natl Acad Sci U S A, 2005 PubMed Europe PMC Scholia
  28. Hahn MK, Blakely RD; ''The functional impact of SLC6 transporter genetic variation.''; Annu Rev Pharmacol Toxicol, 2007 PubMed Europe PMC Scholia
  29. Hoard JL, Hoover DB, Mabe AM, Blakely RD, Feng N, Paolocci N; ''Cholinergic neurons of mouse intrinsic cardiac ganglia contain noradrenergic enzymes, norepinephrine transporters, and the neurotrophin receptors tropomyosin-related kinase A and p75.''; Neuroscience, 2008 PubMed Europe PMC Scholia
  30. Steiner JA, Carneiro AM, Blakely RD; ''Going with the flow: trafficking-dependent and -independent regulation of serotonin transport.''; Traffic, 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134168view00:36, 16 July 2024EweitzStandard node color, case; lighten organelles; economize layout
134167view00:21, 16 July 2024EweitzIncrease font size, for readability
134166view00:10, 16 July 2024EweitzRefine Golgi layout placement
134165view00:07, 16 July 2024EweitzEconomize layout
134164view00:05, 16 July 2024EweitzMitigate Golgi layout discrepancy between PathVisio and Kaavio / Pvjs
134163view00:01, 16 July 2024EweitzRefine legend, economize layout
134162view23:54, 15 July 2024EweitzUse standard organelle graphics, standardize node height
134161view21:56, 15 July 2024EweitzEconomize layout
134160view21:55, 15 July 2024EweitzStandardize case
134159view21:54, 15 July 2024EweitzEconomize layout
116775view09:48, 14 May 2021EweitzModified title
107191view14:28, 17 September 2019MaintBotChEBI identifier normalization
106651view21:13, 12 September 2019KhanspersModified description
105652view05:13, 10 August 2019KhanspersModified description
97828view06:16, 10 June 2018EgonwUndo revision 97756 by [[Special:Contributions/DeSl|DeSl]] ([[User talk:DeSl|Talk]]) Text cannot be copied from other websites.
97756view13:18, 7 June 2018DeSlModified description
94734view14:58, 5 October 2017Mkutmonfix unconnected lines
90193view20:21, 21 October 2016Khanspersfixed unconnected in legend
88905view08:41, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79969view18:59, 28 April 2015Zariannotated anisomycin and catecholamines metabolites
68928view17:33, 8 July 2013MaintBotUpdated to 2013 gpml schema
67491view11:08, 26 June 2013DdiglesOntology Term : 'monoamine transport pathway' added !
41075view23:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
40001view19:05, 23 January 2011AlexanderPicomore descriptive title
34584view22:25, 21 December 2009KhanspersModified categories
34456view18:24, 10 December 2009MaintBotAutomatic update of empty xrefs
33664view20:54, 2 December 2009Dex duncanadd registered user
33426view14:54, 30 November 2009MaintBotRemoved group label
33355view19:10, 24 November 2009Bzhangname change
30181view21:59, 7 July 2009BzhangNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
4-Aminobutanoic acidMetabolite56-12-2 (CAS)
ACHEGeneProduct43 (Entrez Gene) acetylcholinesterase (Yt blood group)
ADORA2AGeneProduct135 (Entrez Gene) adenosine A2a receptor
AGTGeneProduct183 (Entrez Gene) angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AMPHGeneProduct273 (Entrez Gene) amphiphysin
AnisomycinMetaboliteCHEBI:338412 (ChEBI)
CDC25CGeneProduct995 (Entrez Gene) cell division cycle 25 homolog C (S. pombe)
CatecholamineMetaboliteCHEBI:33567 (ChEBI)
CitalopramMetabolite59729-33-8 (CAS)
DBHGeneProduct1621 (Entrez Gene) dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DopamineMetabolite51-61-6 (CAS)
EpinephrineMetabolite51-43-4 (CAS)
FBXO32GeneProduct114907 (Entrez Gene) F-box protein 32
HEPESMetabolite7365-45-9 (CAS)
HRH3GeneProduct11255 (Entrez Gene) histamine receptor H3
Hemicholinium-3Metabolite312-45-8 (CAS)
IL1BGeneProduct3553 (Entrez Gene) interleukin 1 beta
IL1R1GeneProduct3554 (Entrez Gene) interleukin 1 receptor, type I
ITGB3GeneProduct3690 (Entrez Gene) integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
L-tryptophanMetabolite73-22-3 (CAS)
MAPK14GeneProduct1432 (Entrez Gene) mitogen activated protein kinase 14
NOS1GeneProduct4842 (Entrez Gene) nitric oxide synthase 1 (neuronal)
NoradrenalineMetabolite51-41-2 (CAS)
PPP2CBGeneProduct5516 (Entrez Gene) protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
PVRL2GeneProduct5819 (Entrez Gene) poliovirus receptor-related 2 (herpesvirus entry mediator B)
Phorbol esterMetabolite16561-29-8 (CAS)
RBL2GeneProduct5934 (Entrez Gene) retinoblastoma-like 2 (p130)
ReserpineMetabolite50-55-5 (CAS)
SB 203580Metabolite152121-47-6 (CAS)
SCAMP2GeneProduct10066 (Entrez Gene) secretory carrier membrane protein 2
SLC5A7GeneProduct60482 (Entrez Gene) solute carrier family 5 (choline transporter), member 7
SLC6A1GeneProduct6529 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, GABA), member 1
SLC6A2GeneProduct6530 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
SLC6A3GeneProduct6531 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
SLC6A4GeneProduct6532 (Entrez Gene) solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
STX1AGeneProduct6804 (Entrez Gene) syntaxin 1A (brain)
SYN1GeneProduct6853 (Entrez Gene) synapsin I
SerotoninMetabolite50-67-9 (CAS)
TDO2GeneProduct6999 (Entrez Gene) tryptophan 2,3-dioxygenase
TGFB1I1GeneProduct7041 (Entrez Gene) transforming growth factor beta 1 induced transcript 1
THGeneProduct7054 (Entrez Gene) tyrosine hydroxylase
TNFGeneProduct7124 (Entrez Gene) tumor necrosis factor
TNFRSF11BGeneProduct4982 (Entrez Gene) tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
TPH2GeneProduct121278 (Entrez Gene) tryptophan hydroxylase 2
TSC2GeneProduct7249 (Entrez Gene) tuberous sclerosis 2
UNC13BGeneProduct10497 (Entrez Gene) unc-13 homolog B (C. elegans)

Annotated Interactions

No annotated interactions

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