MAPK cascade (Homo sapiens)
From WikiPathways
Description
The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities.
Quality Tags
Ontology Terms
Bibliography
- Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008 PubMed Europe PMC Scholia
- Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ARAF | GeneProduct | ENSG00000078061 (Ensembl) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BRAF | GeneProduct | 673 (Entrez Gene) | |
ELK1 | GeneProduct | 2002 (Entrez Gene) | |
GDP | Metabolite | 146-91-8 (CAS) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
GTP | Metabolite | 2564-35-4 (CAS) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
KRAS | GeneProduct | 3845 (Entrez Gene) | |
MAP2 | GeneProduct | 4133 (Entrez Gene) | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | |
MAP2K2 | GeneProduct | 5605 (Entrez Gene) | |
MAP2K3 | GeneProduct | 5606 (Entrez Gene) | |
MAP2K4 | GeneProduct | 6416 (Entrez Gene) | |
MAP2K6 | GeneProduct | 5608 (Entrez Gene) | |
MAP2K7 | GeneProduct | 5609 (Entrez Gene) | |
MAP3K12 | GeneProduct | 7786 (Entrez Gene) | |
MAP3K1 | GeneProduct | 4214 (Entrez Gene) | |
MAP3K2 | GeneProduct | 10746 (Entrez Gene) | |
MAP3K3 | GeneProduct | 4215 (Entrez Gene) | |
MAPK10 | GeneProduct | 5602 (Entrez Gene) | |
MAPK12 | GeneProduct | 6300 (Entrez Gene) | |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MBP | GeneProduct | 4155 (Entrez Gene) | |
MP1 | GeneProduct | 8649 (Entrez Gene) | |
NRAS | GeneProduct | 4893 (Entrez Gene) | |
PLCB3 | GeneProduct | 5331 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RASA3 | GeneProduct | 22821 (Entrez Gene) | |
RRAS | GeneProduct | 6237 (Entrez Gene) | |
RapGAPII | GeneProduct | ||
SIPA1 | GeneProduct | 6494 (Entrez Gene) | not confirmed SwissProt ID - mu: SPA1 MOUSE |
SOS1 | GeneProduct | ENSG00000115904 (Ensembl) | |
SOS2 | GeneProduct | 6655 (Entrez Gene) |
Annotated Interactions
No annotated interactions