Catabolism of skeletal muscle in cachexia (Homo sapiens)
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Description
Cancer related cachexia is a metabolic disease that is defined by an increased breakdown of muscle protein. Muscle breakdown in cachexia occurs mostly due to activation of either the ubiquitin proteasome system, or the autophagy lysosomal system. In this pathway an overview is presented of the different mechanisms that have been found to activate these two systems involved in muscle degradation.
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- Peris-Moreno D, Taillandier D, Polge C; ''MuRF1/TRIM63, Master Regulator of Muscle Mass.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
- Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M; ''FoxO3 controls autophagy in skeletal muscle in vivo.''; Cell Metab, 2007 PubMed Europe PMC Scholia
- Ross S, Hill CS; ''How the Smads regulate transcription.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
- Cai D, Frantz JD, Tawa NE Jr, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE; ''IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.''; Cell, 2004 PubMed Europe PMC Scholia
- Enwere EK, Lacasse EC, Adam NJ, Korneluk RG; ''Role of the TWEAK-Fn14-cIAP1-NF-κB Signaling Axis in the Regulation of Myogenesis and Muscle Homeostasis.''; Front Immunol, 2014 PubMed Europe PMC Scholia
- Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL; ''Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
- Joulia-Ekaza D, Cabello G; ''The myostatin gene: physiology and pharmacological relevance.''; Curr Opin Pharmacol, 2007 PubMed Europe PMC Scholia
- Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL; ''Foxo transcription factors inducethe atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.''; Cell, 2004 PubMed Europe PMC Scholia
- Antonia RJ, Karelehto E, Toriguchi K, Matli M, Warren RS, Pfeffer LM, Donner DB; ''STAT3 regulates inflammatory cytokine production downstream of TNFR1 by inducing expression of TNFAIP3/A20.''; J Cell Mol Med, 2022 PubMed Europe PMC Scholia
- Schiaffino S, Dyar KA, Ciciliot S, Blaauw B, Sandri M; ''Mechanisms regulating skeletal muscle growth and atrophy.''; FEBS J, 2013 PubMed Europe PMC Scholia
- Li YP, Reid MB; ''NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes.''; Am J Physiol Regul Integr Comp Physiol, 2000 PubMed Europe PMC Scholia
- Stefanetti RJ, Voisin S, Russell A, Lamon S; ''Recent advances in understanding the role of FOXO3.''; F1000Res, 2018 PubMed Europe PMC Scholia
- Ma JF, Sanchez BJ, Hall DT, Tremblay AK, Di Marco S, Gallouzi IE; ''STAT3 promotes IFNγ/TNFα-induced muscle wasting in an NF-κB-dependent and IL-6-independent manner.''; EMBO Mol Med, 2017 PubMed Europe PMC Scholia
- Diep S, Maddukuri M, Yamauchi S, Geshow G, Delk NA; ''Interleukin-1 and Nuclear Factor Kappa B Signaling Promote Breast Cancer Progression and Treatment Resistance.''; Cells, 2022 PubMed Europe PMC Scholia
- ''JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia''; Am J Physiol Endocrinol Metab., 2012 PubMed Europe PMC Scholia
- Zhang G, Anderson LJ, Gao S, Sin TK, Zhang Z, Wu H, Jafri SH, Graf SA, Wu PC, Dash A, Garcia JM, Li YP; ''Weight Loss in Cancer Patients Correlates With p38β MAPK Activation in Skeletal Muscle.''; Front Cell Dev Biol, 2021 PubMed Europe PMC Scholia
- Goodman CA, McNally RM, Hoffmann FM, Hornberger TA; ''Smad3 induces atrogin-1, inhibits mTOR and protein synthesis, and promotes muscle atrophy in vivo.''; Mol Endocrinol, 2013 PubMed Europe PMC Scholia
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