TROP2 regulatory signaling (Homo sapiens)

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Up-regulationProteinmRNAProteinmRNAProteinmRNA Down-regulationProtein Components of complex unknownCa2+ Calcium ionProteinProtein Proteins in complexProteinXXXX Proteins with/without phosphositeFACECYNUTROP2-ICD TROP2 intracellular domain Protein-protein interaction Kinase-substrate reaction Leads to through unknown mechanisms or indication of studied cell types Leads to decrease in activity or phosphorylation at sites Translocation of proteins Transcriptional or translational regulation of gene/protein expression Cytoplasm Cell leading edges Focal adhesions NucleusLegend19TACSTD224203, 82683711, 27331In LNCaP cells and xenograftsleading toDNA condensationand decrease inhistone methylationEnhanceddirectionalmigrationTROP2 prevents IGF1 & MDKbinding to IGF1R &ALK, respectively, bycompetitive bindingEnhancesGC cell tolerance tochemotherapyInHUVECsIn GBC-SD andSGC-996 cellsInMTE-4-14 cellsInHCT116cellsIn the leading edges of prostate cancer cells plated on FN TROP2dimerIntracellular(TROP2-ICD)24, 31Ca2+CLDN1CLDN712PARP1CD56PSMAPSASOX2MYCTP63OCT3/4ARUpregulatedin VCaP cells &downregulatedin LNCaP cells& 22Rv1 cells SYPInLNCaPandPC-3cells 1212ABCC1NOTCH1In BGC-823 andHGC27 cells 393939391616CDKN2ACell cycleregulation16PRKAA216PIK3R1PAKT1S473T30844, 7, 97Proliferation and migrationof HN6, SCC4,MG63, KM12SMMNNG/HOS, U2OS,MTE4-14 andPC-9/GR cells4, 7, 25MMP25In 8505C,K1 andFT-133 cellsAP155, 33MAPK8MAPK9T183Y185T183Y185MAPK1T185Y187MAPK3Y204T2025, 14, 23, 27, 3755PTENS380PDPK19999IGF119, 4119, 41MDK411515, 26PRKCAPRKCD26CASP337In A549NSCLCs37MMP1337PECAM1EGFRY1173In A549NSCLCs37ACVRL1IGF1RY1604Y1136Y1150Y1135Y115141414141InHeLacells14, 414141RAC1GTP88ITGB13, 8ITGA5TLN1TLN1814, 27CREB1S133STAT1Y701RB1S780NFKB133SRCY416PTK2Y397InPC3-2cellsJUNIn FT-133,FADU andMTE-4-14 cells29ADAM10 TACSTD2S322CDH138Affinity:CLDN7>CLDN130, 35BCL2BAXInA2780,Hela and C33Acells1, 23CTNNB1FN1VIMCDH1Induces EMTin MGC803cells23, 30CDK4InHelaandC33Acells23In LNCaP &TRAMP C2 cells22CCND1CCNE1CDK2CDKN1BInPanc02, Hela and C33AcellsJAK2Y1008Y1007STAT3Y705S72766In LN-229and U87-MGcells6PSEN2ADAM17 20TACSTD220TROP2-ICD20PSEN1 ADAM17 202, 2020In LNCaPcells 202230Upregulatedin Panc02, Hela,C33ATRAMP C2 &HEP2 cells anddown-regulatedin MTE-4-14 cells3012121212InLNCaP,PC-3,VCaP,DU-145cells1212In LNCaP cells and xenografts,PC-3, andVCaP cells12121212CTNNB11191919In TROP2-overexpressingH1299,CL1-0and H23 lungcancer cellsIn TROP2-overexpressingH1299,CL1-0and H23 lungcancer cells19InH1299 andH23 cells19IGF2R25IGF22525RACK12533333393314, 271214CYNUCYNUFACEIn MTE-4-14 cells141414, 2737 TROP2 regulatory signaling networkPAK4S47488NUMB2020In v-SRC PECcells 9


Description

Schematic representation of TROP2 mediated signaling mechanism in different types of cancers

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Bibliography

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History

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CompareRevisionActionTimeUserComment
134245view00:04, 18 July 2024EweitzOntology Term : '' added !
134244view00:03, 18 July 2024EweitzOntology Term : '' added !
134243view00:01, 18 July 2024EweitzRefine legend, standardize case
126494view20:24, 9 May 2023Khanspersconverted interactions in legend to graphical lines, added xref for Ca2+
124970view20:26, 10 January 2023KhanspersOntology Term : 'signaling pathway' added !
124847view21:13, 14 December 2022EweitzModified title
124560view00:44, 9 November 2022EweitzModified title
124536view08:11, 7 November 2022Rex D A BNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCC1Protein4363 (Entrez Gene)
ACVRL1Protein94 (Entrez Gene)
ADAM10 Protein102 (Entrez Gene)
ADAM17 Protein6868 (Entrez Gene)
AKT1Protein4070 (Entrez Gene)
AP1Protein4070 (Entrez Gene)
ARProtein9076 (Entrez Gene)
BAXProtein581 (Entrez Gene)
BCL2Protein596 (Entrez Gene)
CASP3Protein9076 (Entrez Gene)
CCND1Protein595 (Entrez Gene)
CCNE1Protein898 (Entrez Gene)
CD56Protein9076 (Entrez Gene)
CDH1Protein999 (Entrez Gene)
CDK2Protein1017 (Entrez Gene)
CDK4Protein1019 (Entrez Gene)
CDKN1BProtein1027 (Entrez Gene)
CDKN2AProtein1029 (Entrez Gene)
CLDN1Protein9076 (Entrez Gene)
CLDN7Protein1366 (Entrez Gene)
CREB1Protein3725 (Entrez Gene)
CTNNB1Protein1499 (Entrez Gene)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
EGFRProtein1956 (Entrez Gene)
FN1Protein2335 (Entrez Gene)
IGF1Protein3479 (Entrez Gene)
IGF1RProtein3480 (Entrez Gene)
IGF2Protein3481 (Entrez Gene)
IGF2RProtein3482 (Entrez Gene)
ITGA5Protein3678 (Entrez Gene)
ITGB1Protein3688 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNProtein3725 (Entrez Gene)
MAPK1Protein9076 (Entrez Gene)
MAPK3Protein9076 (Entrez Gene)
MAPK8Protein9076 (Entrez Gene)
MAPK9Protein9076 (Entrez Gene)
MDKProtein4192 (Entrez Gene)
MMP13Protein4322 (Entrez Gene)
MMP2Protein1111 (Entrez Gene)
MYCProtein9076 (Entrez Gene)
NFKB1Protein4790 (Entrez Gene)
NOTCH1Protein4851 (Entrez Gene)
NUMBRna8650 (Entrez Gene)
OCT3/4Protein9076 (Entrez Gene)
PAK4Protein10298 (Entrez Gene)
PARP1Protein9076 (Entrez Gene)
PDPK1Protein4070 (Entrez Gene)
PECAM1Protein5175 (Entrez Gene)
PIK3R1Protein5295 (Entrez Gene)
PRKAA2Protein4851 (Entrez Gene)
PRKCAProtein5578 (Entrez Gene)
PRKCDProtein5580 (Entrez Gene)
PSAProtein9076 (Entrez Gene)
PSEN1 Protein5663 (Entrez Gene)
PSEN2Protein5664 (Entrez Gene)
PSMAProtein9076 (Entrez Gene)
PTENProtein5728 (Entrez Gene)
PTK2Protein5747 (Entrez Gene)
RAC1Protein5879 (Entrez Gene)
RACK1Protein10399 (Entrez Gene)
RB1Protein5925 (Entrez Gene)
SOX2Protein9076 (Entrez Gene)
SRCProtein6714 (Entrez Gene)
STAT1Protein6772 (Entrez Gene)
STAT3Protein9076 (Entrez Gene)
SYPProtein9076 (Entrez Gene)
TACSTD2Protein4070 (Entrez Gene)
TLN1Protein7094 (Entrez Gene)
TP63Protein9076 (Entrez Gene)
VIMProtein7431 (Entrez Gene)

Annotated Interactions

No annotated interactions

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