Dengue-2 interactions with complement and coagulation cascades (Homo sapiens)

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C3aKinin kallikrein systemmembrane attack complexCollagen,basement membrane,activated platelets, etc.Lectin PathwayAntibody/antigencomplexCell lysisMuscle contraction,Chemotaxis,Phagocyte recruitmentInflammation, etc.Coagulation CascadeC3bZymosan,insulin, etc.ThrombinC4aC5aCell adhesion,migration,proliferation, etcAlternative PathwayDegradationFibrinolytic systemPlatelet, monocyte,lymphocyte,endothelial cells,smooth muscle cellsactivation, etcClassical PathwayC3Convertasefibrin degradationproductsMediatorsVascular injuryC3b/BbCell adhesion,migration,proliferation, etcC3b/4b, C3b, C3dC4b/2aClotExtrinsic pathwayCross-linkedfibrin polymerComplement CascadeSERPING1F12C2F3MASP1CFIC8GMCPF2CLUC9HcSERPINE1KLKB1CPB2MASP2CR1BradykininDaf1APOA2SERPINA1PrM/CapMBL1ADNC1SC1QGPrM/CapC3AR1SERPIND1SERPINF2A2MFibrin monomerC6VWFCR2C1RF10BDKRB1CFHCRRYPROS1C1QAC3C1QBKNG1TFPIF7PLATSERPINC1109821PLAUH2-BFF2RPLGF13BFGBDaf2F8PROCF5C7CD59ASERPINA5PLAURC4C5R1THBDF91


Description

Dengue virus infection can give rise to hemorrhagic shock. Highlighted in red are Dengue-2 structural protein interactions with human proteins involved in coagulation, building upon the complement and coagulation cascades described in http://wikipathways.org/index.php/Pathway:WP558 by the following text:

Blood coagulation is a series of coordinated and calcium-dependent proenzyme-to-serine protease conversions likely to be localized on the surfaces of activated cells in vivo. It culminates in the formation of thrombin, the enzyme responsible for the conversion of soluble fibrinogen to the insoluble fibrin clot. The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). Kinin peptides are implicated in many physiological and pathological processes including the regulation of blood pressure and sodium homeostasis, inflammatory processes, and the cardioprotective effects of preconditioning. Complement is a system of plasma proteins that is activated by the presence of pathogens. There are three pathways of complement activation: the classical pathway, the lectin pathway, and the alternative pathway. All of these pathways generate a crucial enzymatic activity that, intern, generates the effector molecules of complement. The three main consequences of complement activation are the opsonization of pathogens, the recruitment of inflammatory and immunocompetent cells, and the direct killing of pathogens.

Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway:map04610)

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Bibliography

  1. Folly BB, Weffort-Santos AM, Fathman CG, Soares LR; ''Dengue-2 structural proteins associate with human proteins to produce a coagulation and innate immune response biased interactome.''; BMC Infect Dis., 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134282view05:23, 20 July 2024EgonwRemoved a template comment
129065view02:21, 10 March 2024EweitzOntology Term : 'kallikrein-kinin cascade pathway' added !
129061view02:02, 10 March 2024EweitzModified description
128610view23:57, 15 February 2024KhanspersOntology Term : 'infectious disease pathway' added !
128609view23:56, 15 February 2024Khanspersconnected nodes
126437view18:22, 28 April 2023EgonwLicense is CCZero
117695view12:18, 22 May 2021EweitzModified title
94779view21:54, 5 October 2017AlexanderPicoRemoved nested groups and checked connected lines
90040view21:51, 8 October 2016MaintBotOntology Term : 'coagulation cascade pathway' added !
90008view23:18, 7 October 2016MaintBotOntology Term : 'dengue disease' added !
90007view23:17, 7 October 2016MaintBotAdded Dengue reference and updated red paths
90006view23:05, 7 October 2016MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
109821GeneProduct109821 (Entrez Gene)
A2MGeneProduct2 (Entrez Gene)
ADNGeneProduct1675 (Entrez Gene)
APOA2GeneProductENSG00000158874 (Ensembl)
BDKRB1GeneProduct623 (Entrez Gene)
BradykininMetabolite58-82-2 (CAS)
C1QAGeneProduct712 (Entrez Gene)
C1QBGeneProduct713 (Entrez Gene)
C1QGGeneProduct714 (Entrez Gene)
C1RGeneProduct715 (Entrez Gene)
C1SGeneProduct716 (Entrez Gene)
C2GeneProduct717 (Entrez Gene)
C3GeneProduct718 (Entrez Gene)
C3AR1GeneProduct719 (Entrez Gene)
C4GeneProduct721 (Entrez Gene)
C5R1GeneProduct728 (Entrez Gene)
C6GeneProduct729 (Entrez Gene)
C7GeneProduct730 (Entrez Gene) MGI:88235 LL:109828
C8GGeneProduct733 (Entrez Gene)
C9GeneProduct735 (Entrez Gene)
CD59AGeneProduct
CFHGeneProduct3075 (Entrez Gene)
CFIGeneProduct3426 (Entrez Gene)
CLUGeneProduct1191 (Entrez Gene) CLU
CPB2GeneProduct1361 (Entrez Gene)
CR1GeneProduct1378 (Entrez Gene)
CR2GeneProduct1380 (Entrez Gene)
CRRYGeneProduct
Daf1GeneProduct1604 (Entrez Gene)
Daf2GeneProduct
F10GeneProduct2159 (Entrez Gene)
F12GeneProduct2161 (Entrez Gene)
F13BGeneProduct2165 (Entrez Gene)
F2GeneProduct2147 (Entrez Gene)
F2RGeneProduct2149 (Entrez Gene)
F3GeneProduct2152 (Entrez Gene)
F5GeneProduct2153 (Entrez Gene)
F7GeneProduct2155 (Entrez Gene)
F8GeneProduct2157 (Entrez Gene)
F9GeneProduct2158 (Entrez Gene)
FGBGeneProduct2244 (Entrez Gene)
Fibrin monomerMetabolite9001-31-4 (CAS)
H2-BFGeneProduct629 (Entrez Gene)
HcGeneProduct1213 (Entrez Gene)
KLKB1GeneProduct3818 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
MASP1GeneProduct5648 (Entrez Gene)
MASP2GeneProduct10747 (Entrez Gene)
MBL1GeneProduct3998 (Entrez Gene)
MCPGeneProduct4179 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PLAURGeneProduct5329 (Entrez Gene)
PLGGeneProduct5340 (Entrez Gene)
PROCGeneProduct5624 (Entrez Gene)
PROS1GeneProduct5627 (Entrez Gene)
PrM/CapGeneProduct
SERPINA1GeneProduct5265 (Entrez Gene)
SERPINA5GeneProduct5104 (Entrez Gene)
SERPINC1GeneProduct462 (Entrez Gene)
SERPIND1GeneProduct3053 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SERPINF2GeneProduct5345 (Entrez Gene)
SERPING1GeneProduct710 (Entrez Gene)
TFPIGeneProduct7035 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)
VWFGeneProduct7450 (Entrez Gene)

Annotated Interactions

No annotated interactions

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