Peroxiredoxin 2 induced ovarian failure (Homo sapiens)
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Ovarian structural degeneration
Size of ovaries decline
Apoptosis
Ovarian failure
Ovarian functional degeneration
The number of follicles and Corpora lutea declines
Aging
CYP11A1
Reactive oxygen species
BAX
JNK
Estradiol-17beta
PARP2
Peroxiredoxin-2
STAR
Progesterone
CASP3
Cytochrome C
HSD3B2
Description
This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway [WP4835_109250.gpml] with a 62.0% conversion rate.
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Bibliography
Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
134631
view
11:22, 23 July 2024
Eweitz
Ontology Term : 'infertility' added !
134354
view
05:43, 21 July 2024
Egonw
Removed a template comment
110299
view
15:10, 2 May 2020
Egonw
Replaced secondary ChEBI identifiers with a primary identifiers.
110067
view
08:43, 16 April 2020
Fehrhart
Ontology Term : 'ovarian dysfunction' added !
110066
view
08:42, 16 April 2020
Fehrhart
Ontology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110065
view
08:41, 16 April 2020
Fehrhart
Modified description
110064
view
08:39, 16 April 2020
Fehrhart
Graphical adjustments
110063
view
08:37, 16 April 2020
Fehrhart
Added reference
109748
view
15:08, 30 March 2020
Bas Lahaije
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
BAX
GeneProduct
ENSG00000087088 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873
CASP3
Protein
ENSG00000164305 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1
CYP11A1
Protein
ENSG00000140459 (Ensembl)
Mitochondrial
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82
Cytochrome C
Metabolite
CHEBI:18070 (ChEBI)
Somatic
Multiple homologues found: En:ENSG00000172115;En:ENSG00000172115;
Estradiol-17beta
Metabolite
CHEBI:16469 (ChEBI)
HSD3B2
Protein
ENSG00000203859 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7
JNK
Protein
P53779 (Uniprot-TrEMBL)
PARP2
GeneProduct
ENSG00000129484 (Ensembl)
Peroxiredoxin-2
Protein
P32119 (Uniprot-TrEMBL)
No homologues found for original id S:Q61171
Progesterone
Metabolite
DB00396 (DrugBank)
Reactive oxygen species
Metabolite
CHEBI:26523 (ChEBI)
STAR
Protein
ENSG00000147465 (Ensembl)
Mitichondrial
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557
Annotated Interactions
No annotated interactions
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