Arsenic metabolism and reactive oxygen species generation (Homo sapiens)

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DMA (V)SOD1ATP1A1Arsenic(5+)GSTO1DMA (III)Activation of oncogenic pathwaysMT-ND1ArsenicMMA (V)Mitochondrial dysfunctionH2OUQCRFS1Arsenic(3+)OXPHOSO2·–CATAS3MTVDAC1ROSSAHSOD2COA3GSHMMA (III)GSSGSDHAH2O2S-adenosylmethionineGSSGGSHAS3MTS-adenosylmethionineSAHGSHGSSGO2·–H2O2


Description

Arsenic induced ROS formation may lead to carcinogenic effects.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M; ''Arsenic: toxicity, oxidative stress and human disease.''; J Appl Toxicol, 2011 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
139842view04:15, 8 July 2025EgonwMerged two descriptions
139549view06:49, 21 June 2025EgonwMore unicode
135216view11:01, 8 August 2024EgonwAdded a reference
134516view12:35, 22 July 2024EweitzStandardize metabolite color, case
134515view12:27, 22 July 2024EweitzFix interaction connection, economize layout
134114view11:13, 21 June 2024EgonwTranslocation
129331view09:06, 27 March 2024MkutmonOntology Term : 'classic metabolic pathway' added !
123583view12:53, 4 August 2022FehrhartOntology Term : 'cancer' added !
123560view18:03, 3 August 2022EgonwTyped a datanode
122729view13:19, 6 May 2022ZDLechAdded references and fixed interactions.
122714view14:14, 4 May 2022ZDLechChange of shape type for node: Activation of oncogenic pathways
122713view14:10, 4 May 2022ZDLechNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AS3MTGeneProductENSG00000214435 (Ensembl)
ATP1A1GeneProductENSG00000163399 (Ensembl)
Activation of oncogenic pathways
Arsenic(3+)MetaboliteCHEBI:35828 (ChEBI)
Arsenic(5+)MetaboliteCHEBI:35829 (ChEBI)
ArsenicMetaboliteCHEBI:27563 (ChEBI)
CATGeneProductENSG00000121691 (Ensembl)
COA3GeneProductENSG00000183978 (Ensembl)
DMA (III)Metabolite161508 (Chemspider)
DMA (V)Metabolite2418 (Chemspider)
GSHMetaboliteCHEBI:16856 (ChEBI)
GSSGMetaboliteCHEBI:17858 (ChEBI)
GSTO1GeneProductENSG00000148834 (Ensembl)
H2O2Metabolite16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
MMA (III)Metabolite141846 (Chemspider)
MMA (V)Metabolite8604 (Chemspider)
MT-ND1GeneProductENSG00000198888 (Ensembl)
Mitochondrial dysfunction
O2·–Metabolite18421 (ChEBI)
OXPHOSPathwayWP111 (WikiPathways)
ROSMetabolite26523 (ChEBI)
S-adenosylmethionineMetaboliteCHEBI:15414 (ChEBI)
SAHMetaboliteCHEBI:16680 (ChEBI)
SDHAGeneProductENSG00000073578 (Ensembl)
SOD1GeneProductENSG00000142168 (Ensembl)
SOD2GeneProductENSG00000112096 (Ensembl)
UQCRFS1GeneProductENSG00000169021 (Ensembl)
VDAC1GeneProductENSG00000213585 (Ensembl)

Annotated Interactions

No annotated interactions

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