Nephrogenesis (Homo sapiens)

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122. Primed nephron progenitor1. Induction of pretubular aggregateNephron progenitor cell3. Epithelialized renal vesiclePretubular aggregate4. Comma-shaped stageFrom ureteric budStromal progenitorGREB1LALDH1A2LHX1WNT9B SIX2RSPO1OSR1TCF21WNT4FGF20MEIS1FGF8FOXD1JAG1RSPO3BMP7PAX2WNT3ANOTCH2


Description

This pathway describes the gene signaling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R; ''Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.''; Development, 2007 PubMed Europe PMC Scholia
  2. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, Cleper R, Landau D, Kovalski Y, Weissman I, Eisenstein I, Soudack M, Wolf HR, Issler N, Lotan D, Anikster Y, Dekel B; ''Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.''; J Am Soc Nephrol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134598view01:11, 23 July 2024EweitzModified description
134597view01:10, 23 July 2024EweitzStandardize case
118777view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118775view15:56, 1 June 2021Fehrhartadded WNT4 interaction with WNT3A
115258view09:18, 8 February 2021FehrhartModified description
115255view09:02, 8 February 2021FehrhartOntology Term : 'kidney disease' added !
115254view09:02, 8 February 2021FehrhartOntology Term : 'Notch signaling pathway' added !
115253view09:01, 8 February 2021FehrhartOntology Term : 'signaling pathway' added !
115249view08:47, 8 February 2021FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALDH1A2GeneProductENSG00000128918 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GREB1LGeneProductENSG00000141449 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
LHX1GeneProductENSG00000274577 (Ensembl)
MEIS1GeneProductENSG00000143995 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT9B GeneProductENSG00000158955 (Ensembl)

Annotated Interactions

No annotated interactions

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