Interactions between immune cells and microRNAs in tumor microenvironment (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none MacrophageLymphocyteCancer cellT cellRegulatoryT cellAPCLegendLymphocytes conversion to regulatory T cells in immunosuppressive microenvironmentEVExtracellular vesicleEVMIR212MIR203AMIR203BEVMIR210MIR23AEVMIR24-1MIR24-2MIR214EVMIRLET7DIFN-a/b SignalingMHCMRX34MIR155TGFBR2SOCS1LPSTRATRBTLR4IRAK4TRAF6IL2RAIL2RBIL2RGCTLA4CD80CD86MIR138-1MIR138-2PDCD1MRG-106(cobomarsen)MIR34AMIR138-1MIR138-2CD274MIR200AMIR200BMIR200CMIR155MIR21PIAS3STAT3CCL5CXCL10CCL2TGFB1TGFB2TGFB3CCL5CXCL10CCL2Th1 cellNKEVMIR21MIR29AMIR21STAT3MIR24-2MIR23AMIR27ASTAT6IL4RMIR146ATLR7TLR8NFKB1NFKB2IL4Name: Interactions between immune cells and microRNAs in tumor microenvironmentOrganism: Homo sapiens


Description

The interplay between immune cells and microRNAs in the tumor microenvironment (TME). MRX34 and MRG‐106 (cobomarsen) are miRNA therapeutic agents. Adapted from figure 1 in Cortez et al.

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Quality Tags

Image:Curated.pngReview changes for Approved
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. Cortez MA, Anfossi S, Ramapriyan R, Menon H, Atalar SC, Aliru M, Welsh J, Calin GA; ''Role of miRNAs in immune responses and immunotherapy in cancer.''; Genes Chromosomes Cancer, 2019 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137119
Approved
view23:04, 27 February 2025KhanspersModified description
134748view23:30, 26 July 2024EweitzOntology Term : 'neoplastic cell' added !
134747view23:29, 26 July 2024EweitzOntology Term : 'professional antigen presenting cell' added !
104316
CPTAC
view20:00, 16 May 2019Khanspersconnected interaction
103720view12:55, 29 March 2019DeSlReplaces secondary ChEBI with primary ID.
103696view19:54, 28 March 2019KhanspersChanged layout to accomodate legend
103678view23:10, 27 March 2019Khanspersadded legend
103672view00:02, 27 March 2019KhanspersModified description
103671view00:00, 27 March 2019KhanspersOntology Term : 'antigen processing and presentation pathway' added !
103670view23:59, 26 March 2019KhanspersOntology Term : 'natural T-regulatory cell' added !
103669view23:59, 26 March 2019KhanspersOntology Term : 'lymphocyte' added !
103668view23:59, 26 March 2019KhanspersOntology Term : 'T cell' added !
103667view23:59, 26 March 2019KhanspersOntology Term : 'macrophage' added !
103666view23:58, 26 March 2019KhanspersOntology Term : 'natural killer cell' added !
103665view23:58, 26 March 2019KhanspersOntology Term : 'immune response pathway' added !
103664view23:57, 26 March 2019KhanspersOntology Term : 'cancer' added !
103663view21:38, 26 March 2019KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
CCL2GeneProductENSG00000108691 (Ensembl)
CCL5GeneProductENSG00000271503 (Ensembl)
CD274GeneProductENSG00000120217 (Ensembl)
CD80GeneProductENSG00000121594 (Ensembl)
CD86GeneProductENSG00000114013 (Ensembl)
CTLA4GeneProductENSG00000163599 (Ensembl)
CXCL10GeneProductENSG00000169245 (Ensembl)
IL2RAGeneProductENSG00000134460 (Ensembl)
IL2RBGeneProductENSG00000100385 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl)
IL4GeneProductENSG00000113520 (Ensembl)
IL4RGeneProductENSG00000077238 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
LPSMetaboliteCHEBI:52603 (ChEBI)
MHCGeneProduct
MIR138-1GeneProductENSG00000207954 (Ensembl)
MIR138-2GeneProductENSG00000207649 (Ensembl)
MIR146AGeneProductENSG00000283733 (Ensembl)
MIR155RnaENSG00000283904 (Ensembl)
MIR200AGeneProductMIR200A (HGNC)
MIR200BGeneProductENSG00000207730 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR203AGeneProductENSG00000207568 (Ensembl)
MIR203BGeneProductENSG00000283165 (Ensembl)
MIR210GeneProductENSG00000199038 (Ensembl)
MIR212GeneProductENSG00000267195 (Ensembl)
MIR214GeneProductENSG00000283844 (Ensembl)
MIR21GeneProductENSG00000284190 (Ensembl)
MIR23AGeneProductENSG00000207980 (Ensembl)
MIR24-1GeneProductENSG00000284459 (Ensembl)
MIR24-2GeneProductENSG00000284387 (Ensembl)
MIR27AGeneProductENSG00000207808 (Ensembl)
MIR29AGeneProductENSG00000284032 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIRLET7DGeneProductENSG00000199133 (Ensembl)
MRG-106 (cobomarsen)Metabolite
MRX34Metabolite
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
PDCD1GeneProductENSG00000188389 (Ensembl)
PIAS3GeneProductENSG00000131788 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TRAGeneProduct6955 (Entrez Gene)
TRAF6GeneProductENSG00000175104 (Ensembl)
TRBGeneProduct6957 (Entrez Gene)

Annotated Interactions

No annotated interactions

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