Canonical and non-canonical TGF-B signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusTrabecular meshwork cellTGF-BetaPP38PSMAD3SMAD4PSMAD2BMPR2BMPR1TGFBR1TGFBR2PJNK2PJNK1LOXL4LOXL1LOXLOXL2BMPGremLOXL4LOXL2LOXL1LOXLOXLOXL1LOXLOXL1LOXL1LOXL4LOXL1LOXL4Name: Canonical and non-canonical TGF-B signalingOrganism: Homo sapiens


Description

This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

  1. Sethi A, Wordinger RJ, Clark AF; ''Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.''; Exp Eye Res, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137224
Approved
view10:05, 1 March 2025EgonwModified description
134950view02:05, 30 July 2024EweitzRefine layout
134949view02:04, 30 July 2024EweitzEconomize layout
134948view01:41, 30 July 2024EweitzRefine state layering
134947view01:40, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134946view01:39, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134945view01:38, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134944view01:37, 30 July 2024EweitzRefine position of cell type label, state indicators
134943view01:36, 30 July 2024EweitzIncrease font size
134942view01:34, 30 July 2024EweitzUse gene symbols, economize layout
134941view01:30, 30 July 2024EweitzRestore state position
134940view01:29, 30 July 2024EweitzEconomize layout
134939view01:27, 30 July 2024EweitzEconomize layout
128070view00:30, 24 January 2024EweitzStandardize case
128069view00:29, 24 January 2024EweitzOntology Term : 'trabecular meshwork cell' added !
116461view10:05, 7 May 2021EweitzModified title
106348view21:35, 21 August 2019KhanspersModified description
105549view06:10, 9 August 2019KhanspersModified description
89272view23:31, 28 August 2016Khanspersadded states, labels, interactions
89112view18:48, 22 August 2016AAR&CoModified description
89061view06:44, 19 August 2016FehrhartMinor cosmetic changes
88954view21:13, 17 August 2016AAR&CoOntology Term : 'Bone morphogenetic proteins signaling pathway' added !
88953view21:11, 17 August 2016AAR&CoOntology Term : 'primary angle-closure glaucoma' added !
88802view21:30, 14 August 2016AAR&CoModified description
88801view21:13, 14 August 2016AAR&CoLiterature Reference Added
88800view21:10, 14 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BMPGeneProductENSG00000168487 (Ensembl)
BMPR1GeneProductENSG00000107779 (Ensembl)
BMPR2GeneProductENSG00000204217 (Ensembl)
GremGeneProductENSG00000166923 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
LOXGeneProductENSG00000113083 (Ensembl)
LOXL1GeneProductENSG00000129038 (Ensembl)
LOXL2GeneProductENSG00000134013 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
P38GeneProductENSG00000112062 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TGF-BetaGeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)

Annotated Interactions

No annotated interactions

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