Rotenone metabolism (Homo sapiens)
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Description
Human metabolism of rotenone is mostly happening because of the CYP3A4 and CyP2C19 enzymes, resulting in two 12a-hydroxyrotenone isomers (rotenolone I and rotenolone II) and 8′-hydroxyrotenone.
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Ontology Terms
Saving...Bibliography
- Caboni P, Sherer TB, Zhang N, Taylor G, Na HM, Greenamyre JT, Casida JE; ''Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.''; Chem Res Toxicol, 2004 PubMed Europe PMC Scholia
- Innos J, Hickey MA; ''Using Rotenone to Model Parkinson's Disease in Mice: A Review of the Role of Pharmacokinetics.''; Chem Res Toxicol, 2021 PubMed Europe PMC Scholia
- Fukami JI, Yamamoto I, Casida JE; ''Metabolism of rotenone in vitro by tissue homogenates from mammals and insects.''; Science, 1967 PubMed Europe PMC Scholia
- ''Oxidative metabolism of rotenone in mammals, fish, and insects and its relation to selective toxicity''; Journal of Agricultural and Food Chemistry, 1969 DOI Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| 8′-hydroxyrotenone | Metabolite | 92207 (PubChem-compound)  | |
| CYP2C19 | GeneProduct | ENSG00000165841 (Ensembl) | |
| CYP3A4 | GeneProduct | ENSG00000160868 (Ensembl) | |
| rotenolone I | Metabolite | 68184 (PubChem-compound) | |
| rotenolone II | Metabolite | 99189 (PubChem-compound) | |
| rotenone | Metabolite | Q412388 (Wikidata) |
Annotated Interactions
No annotated interactions
