Hepatitis C and hepatocellular carcinoma (Homo sapiens)
From WikiPathways
Description
Pathway model based on hub miRNAs and their putative targets from network analysis.
- From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using STRING (http://string-db.org/) and GeneMANIA (http://genemania.org/).
- After topological analysis and network visualization in Cytoscape, the top hub genes were identified.
- miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.
Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Bibliography
- Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Alavian SE, Rezaei Moghadam A, Amiri M; ''How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.''; Hepat Mon, 2016 PubMed Europe PMC Scholia
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Annotated Interactions
No annotated interactions