EGF signaling in vulval development (Caenorhabditis elegans)

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LIGANDLIN-3LET-231SEM-511SOS-1LET-601LIN-451MEK-211MPK-11LIN-311LIN-11lin-39egl-1711RECEPTORSIGNAL TRANSDUCTIONTRANSCRIPTIONAL REGULATORTARGET GENES


Description

EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12. See figure 8 here: http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135393view15:36, 3 September 2024EgonwConverted to use Ensembl identifiers
135298view21:03, 15 August 2024KhanspersModified description
135297view21:02, 15 August 2024Khansperstidy and fix interactions
118368view13:47, 27 May 2021RaatsSfixed unconnected lines
118059view10:37, 24 May 2021EweitzModified title
118058view10:37, 24 May 2021EweitzModified title
68492view20:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
67173view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
49039view19:05, 3 July 2012KyookOntology Term : 'Ras mediated signaling pathway' added !
48969view19:02, 2 July 2012KyookModified description
48968view19:02, 2 July 2012KyookOntology Term : 'EGF/neuregulin signaling pathway' added !
48948view15:53, 30 June 2012MaintBotModified categories
48933view21:42, 29 June 2012Kyookfinished pathway
48932view21:40, 29 June 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
LET-23GeneProductZK1067.1 (WormBase)
LET-60GeneProductZK792.6 (WormBase)
LIN-1GeneProductC37F5.1 (WormBase)
LIN-31GeneProductK10G6.1 (WormBase)
LIN-3GeneProductF36H1.4 (WormBase)
LIN-45GeneProductY73B6A.5 (WormBase)
MEK-2GeneProductY54E10BL.6 (WormBase)
MPK-1GeneProductF43C1.2 (WormBase)
SEM-5GeneProductC14F5.5 (WormBase)
SOS-1GeneProductT28F12.3 (WormBase)
egl-17GeneProductF38G1.2 (WormBase)
lin-39GeneProductC07H6.7 (WormBase)

Annotated Interactions

No annotated interactions

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