EGF signaling in vulval development (Caenorhabditis elegans)
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Description
EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12.
See figure 8 here: http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf
Quality Tags
Ontology Terms
Bibliography
- Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
LET-23 | GeneProduct | WBGene00002299 (Ensembl) | |
LET-60 | GeneProduct | WBGene00002335 (Ensembl) | |
LIN-1 | GeneProduct | WBGene00002990 (Ensembl) | |
LIN-31 | GeneProduct | WBGene00003017 (Ensembl) | |
LIN-3 | GeneProduct | WBGene00002992 (Ensembl) | |
LIN-45 | GeneProduct | WBGene00003030 (Ensembl) | |
MEK-2 | GeneProduct | WBGene00003186 (Ensembl) | |
MPK-1 | GeneProduct | WBGene00003401 (Ensembl) | |
SEM-5 | GeneProduct | WBGene00004774 (Ensembl) | |
SOS-1 | GeneProduct | WBGene00004947 (Ensembl) | |
egl-17 | GeneProduct | WBGene00001185 (Ensembl) | |
lin-39 | GeneProduct | WBGene00003024 (Ensembl) |
Annotated Interactions
No annotated interactions