Cigarette smoke induced lung fibrosis (Homo sapiens)

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Revision as of 12:26, 6 November 2024 by Marvin M2 (Talk | contribs)
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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Regenerationandnormal lung functionLung epithelial cellsNF-kB pathwayFibrosisCigarette smoke exposureCollagen biosynthesisand modifying enzymesIncrease of ROSOverview ofinflammatory mediatorsIncreased activation ofnuclear factor kappa B (NF-kB)Collagen accumulationRelease ofpro-inflammatory mediatorsGrowth factor releaseOxidative stress and ROSName: Cirgarette Smoke Induced Lung FibrosisOrganism: Homo sapiens


Description

Chronic cigarette smoke exposure induced lung fibrosis

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Quality Tags

Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways

Ontology Terms

 

Bibliography

  1. Makena P, Kikalova T, Prasad GL, Baxter SA; ''Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway.''; Int J Mol Sci, 2023 PubMed Europe PMC Scholia
  2. Estornut C, Milara J, Bayarri MA, Belhadj N, Cortijo J; ''Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis.''; Front Pharmacol, 2021 PubMed Europe PMC Scholia
  3. Ding R, Ren X, Sun Q, Sun Z, Duan J; ''An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework.''; J Adv Res, 2023 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135749view13:52, 8 November 2024EweitzModified title
135744
AOP
view13:00, 6 November 2024Marvin M2added literature references and visual cleanup
135743view12:33, 6 November 2024Marvin M2added KE IDs
135742view12:26, 6 November 2024Marvin M2Ontology Term : 'pulmonary fibrosis' added !
129277view13:10, 17 March 2024BurritacoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
Cigarette smoke exposure
Collagen accumulation68 (Other)
Collagen biosynthesis

and

modifying enzymes		PathwayWP2725 (WikiPathways)
Fibrosis1276 (Other)
Growth factor release
Increase of ROS
Increased activation

of nuclear factor kappa B

(NF-kB)		Complex1172 (Other)
Lung epithelial cells
NF-kB pathwayPathwayWP4562 (WikiPathways)
Overview of

inflammatory

mediators		PathwayWP5095 (WikiPathways)
Oxidative stress

and

ROS		PathwayWP554 (WikiPathways)
Regeneration

and

normal lung function
Release of

pro-inflammatory

mediators		1469 (Other)

Annotated Interactions

No annotated interactions

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