T cell modulation and desmoplasia in pancreatic cancer (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Tumor-associated macrophageCD8+ T cellPancreatic cancer cellPancreatic stellate cellAntigen presentingcellT cell functionICOSCD226FASLGAdenosineAdenineHAVCR2UreaL-ornithineTRBC1TRACIL6TGFB1TGFB2TGFB3IL10CCL17PGE2CCL22TGFB2TGFB1TGFB3IL10LGALS9B2MHLA-AFASCXCL12LGALS1ARG1L-argininePVRTNFRSF4VSIRTIGITCD274VEGFAVEGFCIL10LGALS3LGALS1PGFTGFB1TGFB3TGFB2VEGFDVEGFBFAPVTCN1CD276CD40TNFRSF9PDCD1FAPIDO1CD40LGCD28D-tryptophanL-tryptophanCTLA4CD274KynurenineCD86PDCD1LG2CD80TNFSF9TNFSF4PDCD1PDCD1CD274Regulatory T cellENTPD1NT5EMyeloid-derived suppressor cellARG1Name: T cell modulation in pancreatic cancerOrganism: Homo sapiens


Description

T cells are important effector cells in pancreatic cancer. Their function is inhibited by various cellular interactions and secreted factors in the tumor microenvironment (TME). Both immune cells and pancreatic cancer cells are able to modulate T cell activation.

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Quality Tags

Image:Wplogo_31.pngCommunity: PancCanNet
Image:Curated.pngReview changes for Approved

Ontology Terms

Bibliography

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  1. Wu Q, Tian Y, Zhang J, Zhang H, Gu F, Lu Y, Zou S, Chen Y, Sun P, Xu M, Sun X, Xia C, Chi H, Ying Zhu A, Tang D, Wang D; ''Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma.''; Oncotarget, 2017 PubMed Europe PMC Scholia
  2. Lyssiotis CA, Kimmelman AC; ''Metabolic Interactions in the Tumor Microenvironment.''; Trends Cell Biol, 2017 PubMed Europe PMC Scholia
  3. Sideras K, Braat H, Kwekkeboom J, van Eijck CH, Peppelenbosch MP, Sleijfer S, Bruno M; ''Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies.''; Cancer Treat Rev, 2013 PubMed Europe PMC Scholia
  4. Saka D, Gökalp M, Piyade B, Cevik NC, Arik Sever E, Unutmaz D, Ceyhan GO, Demir IE, Asimgil H; ''Mechanisms of T-Cell Exhaustion in Pancreatic Cancer.''; Cancers (Basel), 2020 PubMed Europe PMC Scholia
  5. Wang D, Gu Y, Yan X, Huo C, Wang G, Zhao Y, Teng M, Li Y; ''Role of CD155/TIGIT in Digestive Cancers: Promising Cancer Target for Immunotherapy.''; Front Oncol, 2022 PubMed Europe PMC Scholia
  6. Liu X, Xu J, Zhang B, Liu J, Liang C, Meng Q, Hua J, Yu X, Shi S; ''The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications.''; Mol Cancer, 2019 PubMed Europe PMC Scholia
  7. Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey CJ, Gough MJ, Crittenden MR; ''ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control.''; Sci Rep, 2022 PubMed Europe PMC Scholia
  8. Yang JS, Wang CC, Qiu JD, Ren B, You L; ''Arginine metabolism: a potential target in pancreatic cancer therapy.''; Chin Med J (Engl), 2020 PubMed Europe PMC Scholia
  9. Ren B, Cui M, Yang G, Wang H, Feng M, You L, Zhao Y; ''Tumor microenvironment participates in metastasis of pancreatic cancer.''; Mol Cancer, 2018 PubMed Europe PMC Scholia
  10. Goulart MR, Stasinos K, Fincham REA, Delvecchio FR, Kocher HM; ''T cells in pancreatic cancer stroma.''; World J Gastroenterol, 2021 PubMed Europe PMC Scholia
  11. Hou Z, Pan Y, Fei Q, Lin Y, Zhou Y, Liu Y, Guan H, Yu X, Lin X, Lu F, Huang H; ''Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer.''; J Cancer Res Clin Oncol, 2021 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137575
Approved
view12:10, 4 March 2025EweitzModified title
137574view12:08, 4 March 2025EweitzModified description
137573view12:06, 4 March 2025EweitzOntology Term : 'pancreatic ductal adenocarcinoma' added !
137572view12:02, 4 March 2025EweitzAdd literature reference for PSC, TAM, desmoplasia interactions
137571view11:54, 4 March 2025EweitzAlign, group interacting genes between TAM and PSC cells
137570view11:51, 4 March 2025EweitzAlign receptors with cell membrane
137569view11:50, 4 March 2025EweitzAdd margin below SHH
137568view11:49, 4 March 2025EweitzAdd SHH, VDR, CXCR4 and CXCL4 genes
137567view11:33, 4 March 2025EweitzEconomize layout
137566view11:30, 4 March 2025EweitzAdd TGFB1 and PDGF genes from TAM to PSC
137549view03:23, 4 March 2025EweitzAdd IL4, IL13 nodes from PSC to TAM
137548view03:07, 4 March 2025EweitzAdd more pathways
137547view02:51, 4 March 2025EweitzAdd hedgehog signaling, widen cell and disease nodes
137546view02:46, 4 March 2025EweitzAdd desmoplasia node
137545view02:28, 4 March 2025EweitzModified description
137544view02:25, 4 March 2025EweitzModified description
137543view02:17, 4 March 2025EweitzAdd literature reference to interaction
137542view02:15, 4 March 2025EweitzAdd literature reference to interaction
136826view05:15, 23 February 2025EweitzClear cache
136825view05:14, 23 February 2025EweitzAlign nodes
136824view05:06, 23 February 2025EweitzRefine cell type label position
136823view05:05, 23 February 2025EweitzRefine node position
136822view05:03, 23 February 2025EweitzRefine interaction position
136821view05:02, 23 February 2025EweitzClear board dimension cache
136820view05:02, 23 February 2025EweitzEconomize layout
136819view04:57, 23 February 2025EweitzClear board dimension cache
136818view04:56, 23 February 2025EweitzEconomize layout, improve readability of cell type labels
136817view04:19, 23 February 2025EweitzEconomize layout
136816view03:54, 23 February 2025EweitzEconomize layout
136815view03:50, 23 February 2025EweitzEconomize layout
136814view03:31, 23 February 2025EweitzEconomize layout
136813view03:26, 23 February 2025EweitzEconomize layout
136812view03:18, 23 February 2025EweitzEconomize layout
136811view03:08, 23 February 2025EweitzEconomize layout
136810view02:55, 23 February 2025EweitzEconomize layout
136809view02:48, 23 February 2025EweitzTailor node dimensions
134371
PancCanNet
view13:24, 21 July 2024EgonwRemoved template comments
128646view20:00, 17 February 2024EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
128645view19:58, 17 February 2024EweitzOntology Term : 'myeloid suppressor cell' added !
128644view19:57, 17 February 2024EweitzOntology Term : 'pancreatic stellate cell' added !
128643view19:57, 17 February 2024EweitzOntology Term : 'professional antigen presenting cell' added !
128642view19:55, 17 February 2024EweitzEconomize layout
125927view13:24, 20 March 2023IsabelWassinkMinor layout change
125923view11:07, 20 March 2023IsabelWassinkOntology Term : 'disease pathway' added !
125080view12:44, 20 January 2023IsabelWassinkOntology Term : 'malignant cell' added !
124823view09:24, 13 December 2022IsabelWassinkFixed TRAC, TRBC1 and TGFB1 data nodes for data visualization
124817view08:31, 12 December 2022IsabelWassinkupdated annotation of TRAC and TRBC1
124394view14:45, 25 October 2022IsabelWassinkNew data node names changed to official gene names
124389view11:38, 24 October 2022IsabelWassinkChanged the ARG1 data nodes to the official gene name
124388view11:24, 24 October 2022IsabelWassinkFixed the CCL17 and CCL22 data nodes

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ARG1ProteinP05089 (Uniprot-TrEMBL)
AdenineMetaboliteCHEBI:16708 (ChEBI)
AdenosineMetaboliteCHEBI:16335 (ChEBI)
B2MProteinP61769 (Uniprot-TrEMBL)
CCL17ProteinQ92583 (Uniprot-TrEMBL)
CCL22ProteinO00626 (Uniprot-TrEMBL)
CD226ProteinQ15762 (Uniprot-TrEMBL)
CD274ProteinQ9NZQ7 (Uniprot-TrEMBL)
CD276ProteinQ5ZPR3 (Uniprot-TrEMBL)
CD28ProteinP10747 (Uniprot-TrEMBL)
CD40LGProteinP29965 (Uniprot-TrEMBL)
CD40ProteinP25942 (Uniprot-TrEMBL)
CD80ProteinP33681 (Uniprot-TrEMBL)
CD86ProteinP42081 (Uniprot-TrEMBL)
CTLA4ProteinP16410 (Uniprot-TrEMBL)
CXCL12ProteinP48061 (Uniprot-TrEMBL)
D-tryptophanMetaboliteCHEBI:57719 (ChEBI)
ENTPD1ProteinP49961 (Uniprot-TrEMBL)
FAPProteinQ12884 (Uniprot-TrEMBL)
FASLGProteinP48023 (Uniprot-TrEMBL)
FASProteinP25445 (Uniprot-TrEMBL)
HAVCR2ProteinQ8TDQ0 (Uniprot-TrEMBL)
HLA-AProteinP04439 (Uniprot-TrEMBL)
ICOSProteinQ9Y6W8 (Uniprot-TrEMBL)
IDO1ProteinP14902 (Uniprot-TrEMBL)
IL10ProteinP22301 (Uniprot-TrEMBL)
IL6ProteinP05231 (Uniprot-TrEMBL)
KynurenineMetaboliteCHEBI:28683 (ChEBI)
L-arginineMetaboliteCHEBI:29016 (ChEBI)
L-ornithineMetaboliteCHEBI:15729 (ChEBI)
L-tryptophanMetaboliteCHEBI:57912 (ChEBI)
LGALS1ProteinP09382 (Uniprot-TrEMBL)
LGALS3ProteinP17931 (Uniprot-TrEMBL)
LGALS9ProteinO00182 (Uniprot-TrEMBL)
NT5EProteinP21589 (Uniprot-TrEMBL)
PDCD1LG2ProteinQ9BQ51 (Uniprot-TrEMBL)
PDCD1ProteinQ15116 (Uniprot-TrEMBL)
PGE2MetaboliteCHEBI:15551 (ChEBI)
PGFProteinP49763 (Uniprot-TrEMBL)
PVRProteinP15151 (Uniprot-TrEMBL)
TGFB1ProteinENSG00000105329 (Ensembl) P01137 - UniProt identifier
TGFB2ProteinP61812 (Uniprot-TrEMBL)
TGFB3ProteinP10600 (Uniprot-TrEMBL)
TIGITProteinQ495A1 (Uniprot-TrEMBL)
TNFRSF4ProteinP43489 (Uniprot-TrEMBL)
TNFRSF9ProteinQ07011 (Uniprot-TrEMBL)
TNFSF4ProteinP23510 (Uniprot-TrEMBL)
TNFSF9ProteinP41273 (Uniprot-TrEMBL)
TRACProteinENSG00000277734 (Ensembl) P01848 - UniProt identifier
TRBC1ProteinENSG00000211751 (Ensembl) P01850 - UniProt identifier
UreaMetaboliteCHEBI:16199 (ChEBI)
VEGFAProteinP15692 (Uniprot-TrEMBL)
VEGFBProteinP49765 (Uniprot-TrEMBL)
VEGFCProteinP49767 (Uniprot-TrEMBL)
VEGFDProteinO43915 (Uniprot-TrEMBL)
VSIRProteinQ9H7M9 (Uniprot-TrEMBL)
VTCN1ProteinQ7Z7D3 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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