Urotensin-II-mediated signaling (Homo sapiens)

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Description

Schematic representation of Urotensin-II-mediated signaling pathway

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, Ding Y, Zhang G, Yang C, Zhu Y, Zou Y; ''Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.''; Int J Mol Sci, 2015 PubMed Europe PMC Scholia
  2. Liang DY, Liu LM, Ye CG, Zhao L, Yu FP, Gao DY, Wang YY, Yang ZW; ''Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.''; PLoS One, 2014 PubMed Europe PMC Scholia
  3. Bianca Rd, Mitidieri E, Fusco F, D'Aiuto E, Grieco P, Novellino E, Imbimbo C, Mirone V, Cirino G, Sorrentino R; ''Endogenous urotensin II selectively modulates erectile function through eNOS.''; PLoS One, 2012 PubMed Europe PMC Scholia
  4. Trebicka J, Leifeld L, Hennenberg M, Biecker E, Eckhardt A, Fischer N, Pröbsting AS, Clemens C, Lammert F, Sauerbruch T, Heller J; ''Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats.''; Hepatology, 2008 PubMed Europe PMC Scholia
  5. Zhou CH, Wan YY, Chu XH, Song Z, Xing SH, Wu YQ, Yin XX; ''Urotensin II contributes to the formation of lung adenocarcinoma inflammatory microenvironment through the NF-κB pathway in tumor-bearing nude mice.''; Oncol Lett, 2012 PubMed Europe PMC Scholia
  6. Diebold I, Petry A, Burger M, Hess J, Görlach A; ''NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.''; Mol Biol Cell, 2011 PubMed Europe PMC Scholia
  7. Segain JP, Rolli-Derkinderen M, Gervois N, Raingeard de la Blétière D, Loirand G, Pacaud P; ''Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes.''; J Immunol, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
137394view23:25, 1 March 2025EweitzRemove obsolete metadata fields
137393view23:24, 1 March 2025EweitzEconomize layout
129675view00:45, 22 May 2024EweitzModified title
126484view16:57, 8 May 2023Khanspersremove labels as identifiers from xrefs
126369view17:47, 25 April 2023EgonwNot a mim-conversion
126326view20:57, 21 April 2023KhanspersOntology Term : 'signaling pathway' added !
126325view20:21, 21 April 2023Khanspersxrefs
126315view23:46, 20 April 2023Khanspersxrefs
126314view23:10, 20 April 2023Khanspersmore xrefs
126313view21:08, 20 April 2023Khanspersmore xrefs
126287view05:24, 20 April 2023Khanspersmore xrefs
126260view22:29, 18 April 2023Khanspersadded xrefs to first box
126259view22:06, 18 April 2023Khanspersconnected interactions, converted to graphical line where appropriate
122561view08:39, 16 April 2022EgonwRemove gene symbols which are not valid identifiers in the stated data sources
120968view06:29, 4 February 2022Keshav
120925view19:20, 31 January 2022EgonwFixed the data sources for UniProt identifiers
120900view08:22, 29 January 2022KeshavModified title
120899view08:20, 29 January 2022KeshavNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
A1FM2GeneProduct84883 (Entrez Gene)
ABCA1GeneProduct19 (Entrez Gene)
ACTA2GeneProduct59 (Entrez Gene)
AGTR1GeneProduct185 (Entrez Gene)
AKT1ProteinP31749 (Uniprot-TrEMBL)
ALOX5GeneProduct240 (Entrez Gene)
ATP2A2Protein
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
CAMK2AProteinQ7LDD5 (Uniprot-TrEMBL)
CAMKIIAGeneProductQ7LDD5 (Uniprot-TrEMBL)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CATGeneProduct
CBPGeneProduct1387 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CDK1GeneProduct983 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CHUKProteinO15111 (Uniprot-TrEMBL)
COL1A1GeneProduct1277 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL3A1GeneProduct1281 (Entrez Gene)
COL4A1GeneProduct1277 (Entrez Gene)
CREBGeneProduct
CTNNB1GeneProduct1499 (Entrez Gene)
CYBAGeneProduct1535 (Entrez Gene)
CYBBGeneProduct1536 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
EGFRProteinP00533 (Uniprot-TrEMBL)
ESPL1GeneProduct9700 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FSCN1GeneProduct6624 (Entrez Gene)
GANQProtein
GSK3AProteinP49840 (Uniprot-TrEMBL)
GSK3BProteinP49841 (Uniprot-TrEMBL)
HDAC5ProteinQ9UQL6 (Uniprot-TrEMBL)
HMOX1GeneProduct3162 (Entrez Gene)
HSPA2GeneProduct3306 (Entrez Gene)
ICAM1GeneProduct3383 (Entrez Gene)
IFN-γ GeneProduct
IFNBGeneProduct
IKBKBProteinO14920 (Uniprot-TrEMBL)
IL-6GeneProduct3569 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1β GeneProduct
IL6GeneProduct3569 (Entrez Gene)
IRF3GeneProduct3661 (Entrez Gene)
JAK2ProteinO60674 (Uniprot-TrEMBL)
LTB4GeneProduct
MAPK14ProteinQ16539 (Uniprot-TrEMBL)
MAPK14Protein
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MAPK3ProteinP27361 (Uniprot-TrEMBL)
MAPK8ProteinP45983 (Uniprot-TrEMBL)
MAPK9ProteinP45984 (Uniprot-TrEMBL)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NCF1GeneProduct653361 (Entrez Gene)
NCF2GeneProduct4688 (Entrez Gene)
NCF4GeneProduct4689 (Entrez Gene)
NFKB1AProteinNFKB1A (HGNC)
NFKB1AProtein
NFKB1ProteinP19838 (Uniprot-TrEMBL)
NOX4GeneProduct50507 (Entrez Gene)
NPPAGeneProduct
NPPAGeneProduct4878 (Entrez Gene)
NPPBGeneProduct4879 (Entrez Gene)
PCNAGeneProduct5111 (Entrez Gene)
PI3KCAProtein
PIP2Protein
PIP3Protein
PLCGeneProduct
PLNProteinP26678 (Uniprot-TrEMBL)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACAProteinP17612 (Uniprot-TrEMBL)
PTENGeneProduct5728 (Entrez Gene)
PTENProteinP60484 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
ProteinGeneProduct
RELAProteinQ04206 (Uniprot-TrEMBL)
RHOAProteinP61586 (Uniprot-TrEMBL)
SMAD2GeneProductSMAD2 (HGNC)
SMAD3GeneProduct4088 (Entrez Gene)
SOD2GeneProduct
STAT3Protein6774 (Entrez Gene)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TFGeneProduct
TGFB1GeneProduct7040 (Entrez Gene)
TNF-alphaGeneProduct
TNFGeneProduct7124 (Entrez Gene)
TRPC4ProteinQ9UBN4 (Uniprot-TrEMBL)
UTRProteinQ9UKP6 (Uniprot-TrEMBL)
Urotensin-IIProteinO95399 (Uniprot-TrEMBL)
VCAM1GeneProduct7412 (Entrez Gene)
p300GeneProduct2033 (Entrez Gene)

Annotated Interactions

No annotated interactions

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