Age-related macular degeneration (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none mTORC1AMPKMalateMitochondrionorganizationand biogenesisSIRT1RPTORMTORRPTORMLST8RPS6KB1MAPK3PMAIP1MDH1AlphaPRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3BetaGammaLipiddegenerationAutophagyRibosomebiogenesis andassemblyGlycolysisMitochondrialdamageApoptosisOxaloacetateNAD+PARP2PPARGC1AName: Age-related macular degenerationOrganism: Homo sapiens


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

  1. Zhang M, Jiang N, Chu Y, Postnikova O, Varghese R, Horvath A, Cheema AK, Golestaneh N; ''Dysregulated metabolic pathways in age-related macular degeneration.''; Sci Rep, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138229
Approved
view01:21, 26 March 2025EweitzFix truncated text
138219view12:23, 25 March 2025EweitzConvey up- vs. down-regulation in disease via font style, refine legend
138218view12:03, 25 March 2025EweitzRefine interactions, start legend
138217view03:59, 25 March 2025EweitzOntology Term : 'age related macular degeneration' added !
138216view03:59, 25 March 2025EweitzOntology Term : 'retinal pigment epithelial cell' added !
138215view03:59, 25 March 2025EweitzModified description
138214view03:57, 25 March 2025EweitzModified description
138213view03:56, 25 March 2025EweitzModified description
138212view03:51, 25 March 2025EweitzAdd literature reference
138211view03:49, 25 March 2025EweitzLabel cell type
138210view03:42, 25 March 2025EweitzAdd more interactions
138209view03:31, 25 March 2025EweitzConvert unknowns to pathways, add cell compartments
138208view03:20, 25 March 2025EweitzUpgrade nodes, identify pathways
138207view03:15, 25 March 2025EweitzIdentify metabolites
138206view02:56, 25 March 2025EweitzEconomize layout
138205view02:53, 25 March 2025EweitzAdd interactions
138204view02:25, 25 March 2025EweitzAdd process, metabolite nodes
138203view02:09, 25 March 2025EweitzArrange nodes
138202view21:46, 24 March 2025EweitzAdd AMPK complex, with explicit genes
138201view21:44, 24 March 2025EweitzNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP254 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
GlycolysisPathwayWP534 (WikiPathways)
Lipid degenerationPathway
MAPK3GeneProductENSG00000102882 (Ensembl)
MDH1GeneProductENSG00000014641 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MalateMetaboliteCHEBI:25115 (ChEBI)
Mitochondrial damagePathway
Mitochondrion

organization

and biogenesis		Pathway
NAD+MetaboliteCHEBI:15846 (ChEBI)
OxaloacetateMetaboliteCHEBI:16452 (ChEBI)
PARP2GeneProductENSG00000129484 (Ensembl)
PMAIP1GeneProductENSG00000141682 (Ensembl)
PPARGC1AGeneProductENSG00000109819 (Ensembl) "PGC1a" in source
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
Ribosome

biogenesis and

assembly		Pathway
SIRT1GeneProductENSG00000096717 (Ensembl)

Annotated Interactions

No annotated interactions

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