Visual cycle (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none RDH12RBP3LRATRDH10RDH5RLBP1RDH8RBP1RPE65RDH11OPN1SWRHOOPN1MWOPN1LWABCA4Name: Retinoid cycle metabolic pathwayOrganism: Homo sapiens


Description

No description

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Quality Tags

Image:Curated.pngReview changes for Approved

Ontology Terms

 

Bibliography

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  1. Kiser PD, Golczak M, Maeda A, Palczewski K; ''Key enzymes of the retinoid (visual) cycle in vertebrate retina.''; Biochim Biophys Acta, 2012 PubMed Europe PMC Scholia
  2. Wang JS, Kefalov VJ; ''The cone-specific visual cycle.''; Prog Retin Eye Res, 2011 PubMed Europe PMC Scholia
  3. Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K; ''Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  4. Pollock NL, Callaghan R; ''The lipid translocase, ABCA4: seeing is believing.''; FEBS J, 2011 PubMed Europe PMC Scholia
  5. Persson B, Kallberg Y, Oppermann U, Jörnvall H; ''Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).''; Chem Biol Interact, 2003 PubMed Europe PMC Scholia
  6. von Lintig J; ''Metabolism of carotenoids and retinoids related to vision.''; J Biol Chem, 2012 PubMed Europe PMC Scholia
  7. Kiser PD, Palczewski K; ''Membrane-binding and enzymatic properties of RPE65.''; Prog Retin Eye Res, 2010 PubMed Europe PMC Scholia
  8. Bray JE, Marsden BD, Oppermann U; ''The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.''; Chem Biol Interact, 2009 PubMed Europe PMC Scholia
  9. von Lintig J, Kiser PD, Golczak M, Palczewski K; ''The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.''; Trends Biochem Sci, 2010 PubMed Europe PMC Scholia
  10. Takahashi Y, Moiseyev G, Chen Y, Ma JX; ''The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity.''; Invest Ophthalmol Vis Sci, 2006 PubMed Europe PMC Scholia
  11. Jörnvall H, Hedlund J, Bergman T, Oppermann U, Persson B; ''Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.''; Biochem Biophys Res Commun, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
138466
Approved
view20:02, 11 April 2025EgonwModified description
138465view16:29, 11 April 2025EgonwModified description
138416view18:53, 6 April 2025EweitzRefine label
138415view18:48, 6 April 2025EweitzEconomize layout
138414view18:35, 6 April 2025EweitzEconomize layout
138412view13:47, 6 April 2025EweitzOntology Term : 'retinal rod cell' added !
138411view13:47, 6 April 2025EweitzOntology Term : 'compound eye cone cell' added !
138410view13:47, 6 April 2025EweitzOntology Term : 'retinal pigment epithelial cell' added !
138409view13:46, 6 April 2025EweitzOntology Term : 'retinoid cycle metabolic pathway' added !
138408view13:45, 6 April 2025EweitzModified description
138407view13:44, 6 April 2025EweitzModified description
138406view13:40, 6 April 2025EweitzAdd literature references
138405view13:34, 6 April 2025EweitzEconomize layout
138404view13:32, 6 April 2025EweitzAdd cells
138403view13:21, 6 April 2025EweitzModified title
138402view13:18, 6 April 2025EweitzAdd interactions, arrange
138401view22:51, 5 April 2025EweitzArrange nodes
138400view22:24, 5 April 2025EweitzAdd, identify metabolites
138399view21:58, 5 April 2025EweitzArrange genes
138398view21:50, 5 April 2025EweitzAdd identifiers to genes
138397view21:40, 5 April 2025EweitzNew pathway

External references

DataNodes

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Name  ↓Type  ↓Database reference  ↓Comment  ↓
ABCA4GeneProductENSG00000198691 (Ensembl)
LRATGeneProductENSG00000121207 (Ensembl)
OPN1LWGeneProductENSG00000102076 (Ensembl)
OPN1MWGeneProductENSG00000268221 (Ensembl)
OPN1SWGeneProductENSG00000128617 (Ensembl)
RBP1GeneProductENSG00000114115 (Ensembl)
RBP3GeneProductENSG00000265203 (Ensembl)
RDH10GeneProductENSG00000121039 (Ensembl)
RDH11GeneProductENSG00000072042 (Ensembl)
RDH12GeneProductENSG00000139988 (Ensembl)
RDH5GeneProductENSG00000135437 (Ensembl)
RDH8GeneProductENSG00000080511 (Ensembl)
RHOGeneProductENSG00000163914 (Ensembl)
RLBP1GeneProductENSG00000140522 (Ensembl)
RPE65GeneProductENSG00000116745 (Ensembl)

Annotated Interactions

No annotated interactions

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