Celiac disease mechanism and therapies (Homo sapiens)

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Revision as of 11:31, 1 July 2025 by Eweitz (Talk | contribs)
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Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Vicari AP, Schoepfer AM, Meresse B, Goffin L, Léger O, Josserand S, Guégan N, Yousefi S, Straumann A, Cerf-Bensussan N, Simon HU, Chvatchko Y; ''Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.''; MAbs, 2017 PubMed Europe PMC Scholia
  2. Dieckman T, Koning F, Bouma G; ''Celiac disease: New therapies on the horizon.''; Curr Opin Pharmacol, 2022 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
140410view06:54, 18 August 2025Sikedafixed a datasource
139786view06:35, 6 July 2025EgonwAdded two Wikidata IDs + one extra reference
139780view04:18, 5 July 2025EgonwFixed a datasource
139779view04:16, 5 July 2025EgonwAdded Wikidata IDs for two inhibitors
139728view11:46, 1 July 2025EweitzOntology Term : 'intestinal epithelial cell' added !
139727view11:45, 1 July 2025EweitzOntology Term : 'CD8-positive, alpha-beta T cell' added !
139725view11:45, 1 July 2025EweitzOntology Term : 'professional antigen presenting cell' added !
139724view11:44, 1 July 2025EweitzOntology Term : 'CD4-positive, alpha-beta T cell' added !
139723view11:44, 1 July 2025EweitzOntology Term : 'drug pathway' added !
139722view11:43, 1 July 2025EweitzOntology Term : 'celiac disease' added !
139721view11:39, 1 July 2025EweitzModified description
139720view11:31, 1 July 2025EweitzAdd drug, chemical identifiers
139718view11:26, 1 July 2025EweitzAdd gene identifiers, refine HLA genes
139710view09:55, 1 July 2025EweitzAdd literature reference
139368view10:10, 6 June 2025EweitzUpdate
139343view11:30, 3 June 2025EweitzClarify drug mechanism of inhibition loss of tolerance
139342view11:21, 3 June 2025EweitzAdd phenotype, zonulin receptors
139339view10:45, 3 June 2025EweitzAdd drugs, genes, refine interactions
139332view01:46, 3 June 2025EweitzAdd drugs
139331view23:15, 2 June 2025EweitzAdd interactions between APC and CD4 T cell
139330view22:20, 2 June 2025EweitzAdd more interactions, tissue labels
139329view11:32, 2 June 2025EweitzAdd catalysis, economize layout
139327view03:17, 2 June 2025EweitzAdd interactions, label microanatomy
139326view02:44, 2 June 2025EweitzAdd genes
139325view01:53, 2 June 2025EweitzAdd blood vessel, color tissues
139324view01:28, 2 June 2025EweitzAdd more cell types
139323view01:17, 2 June 2025EweitzColor, refine size in IECs
139322view01:12, 2 June 2025EweitzAdd villi, mucus layer, CD8 T cell
139319view20:17, 31 May 2025EweitzNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AGYMetabolite
CALY-002Metabolite
CD4GeneProductENSG00000010610 (Ensembl)
DHODHGeneProductENSG00000102967 (Ensembl)
Deaminated

gluten

peptide		MetaboliteCHEBI:192208 (ChEBI)
EGFRGeneProductENSG00000146648 (Ensembl)
F2RL1GeneProductENSG00000164251 (Ensembl) "PAR2" in source
GSK3915393Metabolite
GZMBGeneProductENSG00000100453 (Ensembl)
Gluten peptideMetaboliteCHEBI:192208 (ChEBI)
GlutenMetaboliteCHEBI:192208 (ChEBI)
HLA-DQA1GeneProduct
HLA-DQB1GeneProduct
IFNGGeneProductENSG00000111537 (Ensembl)
IL15GeneProductENSG00000164136 (Ensembl)
IL21GeneProductENSG00000138684 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
ITGA4GeneProductENSG00000115232 (Ensembl)
ITGB7GeneProductENSG00000139626 (Ensembl)
Inflammation
KAN-101Metabolite
LarazotideMetaboliteDB05645 (DrugBank)
LatiglutenaseMetaboliteDB06326 (DrugBank)
Loss of tolerance
PRV-015Metabolite
PTG-100Metabolite
Pyrimidine synthesisPathway
TAK-062Metabolite
TAK-101Metabolite
TGM2GeneProductTGM2 (Ensembl) "TG2" in source
TNFAGeneProductENSG00000232810 (Ensembl)
TRAGeneProduct6955 (Entrez Gene)
TeriflunomideMetaboliteDB08880 (ChEBI)
Tolerase GMetabolite
ZED1227Metabolite

Annotated Interactions

No annotated interactions

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