Oxidative stress in pulmonary tissue (Homo sapiens)
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Description
Adverse Outcome Pathway (AOP) for stressor induced increase in ROS production (oxidative stress) in pulmonary tissue.
Quality Tags
Ontology Terms
Saving...Bibliography
- Sajal Chakraborti, Narasimham L. Parinandi, Rita Ghosh, Nirmal K. Gangul, Tapati Chakraborti; ''Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases''; Pubmed, 2019 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| AO1: Idophatic pulmonary fibrosis | 1458 (Other)  | ||
| AO2: COPD | |||
| AO3: Acute respiratory distress syndrome | |||
| AO4: Asthma | |||
| Apoptosis | Pathway | WP254 (WikiPathways) | |
| Carbon monoxide | |||
| Chemokine signalling pathway | Pathway | WP3929 (WikiPathways) | |
| Cigarette smoke | |||
| Emission from biomass fuel and combusiton | |||
| Industrial smoke | |||
| KE1: Increased oxidative stress | 1392 (Other) | ||
| KE2: Inflammation and pro-fibrotic state | 1497 (Other) | ||
| KE3: Cell death and cycle arrest | |||
| KE4: Mitrochondrial dysfucntion | 177 (Other) | ||
| KE5: Collagen production and reduced ECM | |||
| KE6: ER stress | |||
| MIE1: ROS production upregulation | |||
| Nitrogen oxides | |||
| Ozone | |||
| Particulate matter | |||
| Pesticides | |||
| Pollen grains | |||
| Profibrotic pathway | Pathway | WP3624 (WikiPathways) | |
| ROS damage pathway | Pathway | WP5477 (WikiPathways) | |
| Release of pro-inflammatory cytokines | Pathway | WP530 (WikiPathways) | |
| Senescence | Pathway | WP2902 (WikiPathways) | |
| Sulphur oxides |
Annotated Interactions
No annotated interactions
