HLA-C allotypes interactions with KIR on dNK cells (Homo sapiens)

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Description

KIR- HLA-C interaction

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Bibliography

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History

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CompareRevisionActionTimeUserComment
140008view14:47, 17 July 2025Johidi2Legend has been updated and a state has been added to datanodes from pathway refinement for a better overview
139977view22:53, 14 July 2025Johidi2Pathway has been refined with expression data and a legend was added.
139925view09:53, 11 July 2025EgonwRemoved a template comment
139924view21:31, 10 July 2025Johidi2Modified description
139923view21:17, 10 July 2025Johidi2Modified description
139917view11:33, 10 July 2025DeSlUpdated title and description
139916view11:30, 10 July 2025DeSlOntology Term : 'female reproductive system disease' added !
139915view11:27, 10 July 2025DeSlOntology Term : 'altered tumor necrosis factor mediated signaling pathway' added !
139914view11:25, 10 July 2025DeSlOntology Term : 'signaling pathway' added !
139913view11:24, 10 July 2025DeSlOntology Term : 'uterine natural killer cell' added !
139912view11:23, 10 July 2025DeSlOntology Term : 'tumor necrosis factor superfamily mediated signaling pathway' added !
139911view11:20, 10 July 2025DeSlUpdating layout
139910view10:56, 10 July 2025Johidi2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CD34(+)
  • CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.
  • Cell type ontology: CL:0001024
DAGProteinP17252 (Uniprot-TrEMBL)
DAP12ProteinO43914 (Uniprot-TrEMBL) Contains immunoreceptor tyrosine-based activation motif (ITAM)
EVT cell
  • Extravillous trophoblast. A trophoblast cell that is not part of a placental villous. Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy.
  • Cell type ontology: CL:0008036
FYNProteinP06241 (Uniprot-TrEMBL)
GM-CSFProteinP04141 (Uniprot-TrEMBL)
  • Enhances trophoblast motility
  • Transwell assays with conditioned media
HLA-CProteinP10321 (Uniprot-TrEMBL)
IFN-γProteinP01579 (Uniprot-TrEMBL)
  • Robustly produced following activating KIR engagement.
  • IFN-γ inhibits trophoblast invasion by inducing apoptosis and suppressing protease activity
  • Transcriptome profiling via microarray
IP3ProteinQ14643 (Uniprot-TrEMBL)
KIR2DL1ProteinP43626 (Uniprot-TrEMBL) Cytoplasmic tail contains ITIM motif
KIR2DL2 ProteinP43627 (Uniprot-TrEMBL)
KIR2DL3ProteinP43628 (Uniprot-TrEMBL)
KIR2DS1ProteinQ14954 (Uniprot-TrEMBL)
LATProteinO43561 (Uniprot-TrEMBL)
MAPK PathwayPathwayWP769 (WikiPathways)
NF-kbPathwayWP4562 (WikiPathways)
NK-precursor cell
  • CD34 (-)CD117(+)CD94(-) NK precursor cells in the peripheral blood
  • Cell type ontology CL:0000823
PBNK cell
  • Peripheral blood natural killer cell. A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.
  • Cell type ontology: CL:0000623
PI3K-Akt PathwayPathwayWP4172 (WikiPathways)
PKCProteinQ04759 (Uniprot-TrEMBL)
PLC-γ1ProteinP19174 (Uniprot-TrEMBL)
RAC1ProteinP63000 (Uniprot-TrEMBL)
SHP-1ProteinP29350 (Uniprot-TrEMBL)
SHP-2ProteinP17706 (Uniprot-TrEMBL)
SLP-76ProteinQ13094 (Uniprot-TrEMBL)
SykProteinP43405 (Uniprot-TrEMBL)
TNF-alpha signalingPathwayWP231 (WikiPathways) This pathway details the signaling events initiated by TNF-α, including activation of NF-κB, apoptosis, and inflammatory gene expression. While it is not trophoblast-specific, the pathway covers the core mechanisms by which TNF-α regulates immune responses and cell behavior, which are directly relevant to its roles in immune regulation and inhibition of trophoblast invasion.
TNF-αProteinP01375 (Uniprot-TrEMBL)
  • Via its action on endometrial stromal cells, TNF-α can also indirectly promote trophoblast invasion by creating a supportive inflammatory environment
  • Elevated TNF-α impairs trophoblast migration and invasion
  • This duality highlights the importance of tightly regulated TNF-α signaling for successful implantation and placental development
Type II interferon signalingPathwayWP619 (WikiPathways) The canonical IFN-γ signaling pathway, including JAK/STAT activation and downstream gene regulation. While it does not specifically mention trophoblasts, it shows how IFN-γ can induce gene expression changes leading to apoptosis and immune modulation.
VAV1ProteinP15498 (Uniprot-TrEMBL)
VEGF-APathwayWP3888 (WikiPathways) Supports trophoblast growth and vascular remodeling
VEGFA-VEGFR2 PathwayPathwayWP3888 (WikiPathways) This pathway is critical for EVT function and spiral artery remodeling, and its disruption is linked to pregnancy complications such as preeclampsia and recurrent pregnancy loss
dNK cell
  • Decidual natural killer cell. A natural killer cell subset that is found in the decidual of the uterus CD56brightCD16- phenotype. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy.
  • Cell type ontology: CL:0002343
eNK cell
  • Endometrial natural killer cell. ​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state
  • Cell type ontology: CL:4052051
uNK cell
  • Uterine natural killer cell. A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy.
  • Cell type ontology: CL:4052028

Annotated Interactions

No annotated interactions

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