HLA-C allotypes interactions with KIR on dNK cells (Homo sapiens)

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History

External references

DataNodes

Name	Type	Database reference	Comment
CD34(+)			CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive. Cell type ontology: CL:0001024
DAG	Protein	P17252 (Uniprot-TrEMBL)
DAP12	Protein	O43914 (Uniprot-TrEMBL)	Contains immunoreceptor tyrosine-based activation motif (ITAM)
EVT cell			Extravillous trophoblast. A trophoblast cell that is not part of a placental villous. Extravillous trophoblasts (EVTs), a specialized subset of trophoblast cells, play crucial roles in establishing and sustaining pregnancy. Cell type ontology: CL:0008036
FYN	Protein	P06241 (Uniprot-TrEMBL)
GM-CSF	Protein	P04141 (Uniprot-TrEMBL)	Enhances trophoblast motility Transwell assays with conditioned media
HLA-C	Protein	P10321 (Uniprot-TrEMBL)
IFN-γ	Protein	P01579 (Uniprot-TrEMBL)	Robustly produced following activating KIR engagement. IFN-γ inhibits trophoblast invasion by inducing apoptosis and suppressing protease activity Transcriptome profiling via microarray
IP3	Protein	Q14643 (Uniprot-TrEMBL)
KIR2DL1	Protein	P43626 (Uniprot-TrEMBL)	Cytoplasmic tail contains ITIM motif
KIR2DL2	Protein	P43627 (Uniprot-TrEMBL)
KIR2DL3	Protein	P43628 (Uniprot-TrEMBL)
KIR2DS1	Protein	Q14954 (Uniprot-TrEMBL)
LAT	Protein	O43561 (Uniprot-TrEMBL)
MAPK Pathway	Pathway	WP769 (WikiPathways)
NF-kb	Pathway	WP4562 (WikiPathways)
NK-precursor cell			CD34 (-)CD117(+)CD94(-) NK precursor cells in the peripheral blood Cell type ontology CL:0000823
PBNK cell			Peripheral blood natural killer cell. A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. Cell type ontology: CL:0000623
PI3K-Akt Pathway	Pathway	WP4172 (WikiPathways)
PKC	Protein	Q04759 (Uniprot-TrEMBL)
PLC-γ1	Protein	P19174 (Uniprot-TrEMBL)
RAC1	Protein	P63000 (Uniprot-TrEMBL)
SHP-1	Protein	P29350 (Uniprot-TrEMBL)
SHP-2	Protein	P17706 (Uniprot-TrEMBL)
SLP-76	Protein	Q13094 (Uniprot-TrEMBL)
Syk	Protein	P43405 (Uniprot-TrEMBL)
TNF-alpha signaling	Pathway	WP231 (WikiPathways)	This pathway details the signaling events initiated by TNF-α, including activation of NF-κB, apoptosis, and inflammatory gene expression. While it is not trophoblast-specific, the pathway covers the core mechanisms by which TNF-α regulates immune responses and cell behavior, which are directly relevant to its roles in immune regulation and inhibition of trophoblast invasion.
TNF-α	Protein	P01375 (Uniprot-TrEMBL)	Via its action on endometrial stromal cells, TNF-α can also indirectly promote trophoblast invasion by creating a supportive inflammatory environment Elevated TNF-α impairs trophoblast migration and invasion This duality highlights the importance of tightly regulated TNF-α signaling for successful implantation and placental development
Type II interferon signaling	Pathway	WP619 (WikiPathways)	The canonical IFN-γ signaling pathway, including JAK/STAT activation and downstream gene regulation. While it does not specifically mention trophoblasts, it shows how IFN-γ can induce gene expression changes leading to apoptosis and immune modulation.
VAV1	Protein	P15498 (Uniprot-TrEMBL)
VEGF-A	Pathway	WP3888 (WikiPathways)	Supports trophoblast growth and vascular remodeling
VEGFA-VEGFR2 Pathway	Pathway	WP3888 (WikiPathways)	This pathway is critical for EVT function and spiral artery remodeling, and its disruption is linked to pregnancy complications such as preeclampsia and recurrent pregnancy loss
dNK cell			Decidual natural killer cell. A natural killer cell subset that is found in the decidual of the uterus CD56brightCD16- phenotype. This cell type represents the most abundant immune cell type in the decidual during the first trimester of pregnancy. Cell type ontology: CL:0002343
eNK cell			Endometrial natural killer cell. ​​A uterine natural killer subset that is present in the endometrial lining during the non-pregnant state Cell type ontology: CL:4052051
uNK cell			Uterine natural killer cell. A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy. Cell type ontology: CL:4052028

Annotated Interactions

No annotated interactions