Alzheimer's disease (Homo sapiens)

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Description

This pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. Note: mitochondrial associated genes Cx I through Cx V are not currently included, as these correspond to over a hundred distinct factors. Adapted from [KEGG](https://www.kegg.jp/pathway/hsa05010).

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Ontology Terms

 

Bibliography

View all...
  1. Avila J; ''Tau phosphorylation and aggregation in Alzheimer's disease pathology.''; FEBS Lett, 2006 PubMed Europe PMC Scholia
  2. Cowburn RF, Popescu BO, Ankarcrona M, Dehvari N, Cedazo-Minguez A; ''Presenilin-mediated signal transduction.''; Physiol Behav, 2007 PubMed Europe PMC Scholia
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  9. Wasser CR, Herz J; ''Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.''; J Biol Chem, 2017 PubMed Europe PMC Scholia
  10. Lane-Donovan C, Herz J; ''ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.''; Trends Endocrinol Metab, 2017 PubMed Europe PMC Scholia
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  16. Katayama T, Imaizumi K, Manabe T, Hitomi J, Kudo T, Tohyama M; ''Induction of neuronal death by ER stress in Alzheimer's disease.''; J Chem Neuroanat, 2004 PubMed Europe PMC Scholia
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  19. Palomer E, Buechler J, Salinas PC; ''Wnt Signaling Deregulation in the Aging and Alzheimer's Brain.''; Front Cell Neurosci, 2019 PubMed Europe PMC Scholia
  20. Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G; ''Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.''; Aging Cell, 2008 PubMed Europe PMC Scholia
  21. Bezprozvanny I, Mattson MP; ''Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease.''; Trends Neurosci, 2008 PubMed Europe PMC Scholia
  22. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH; ''Neurotoxicity induces cleavage of p35 to p25 by calpain.''; Nature, 2000 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
142379view16:28, 30 January 2026DeSlAnnotated two pathways and added comment for third one.
142335view14:46, 23 January 2026DdiglesAdded IDs for mitochondrial respiratory chain complexes Cx I - V
140419view06:20, 21 August 2025EgonwMore unicode
140356view08:51, 14 August 2025EgonwMore unicode
139898view05:13, 10 July 2025EgonwCalcium ion with unicode
139852view11:07, 8 July 2025DdiglesDeleted hidden old description
139393view19:14, 13 June 2025KhanspersModified description
139390view21:51, 12 June 2025Khanspersminor layout change
139357view17:31, 5 June 2025KhanspersModified description
137634view21:58, 5 March 2025KhanspersModified description
136483view12:36, 4 February 2025EweitzWiden microglia
136482view12:35, 4 February 2025EweitzEconomize layout
136481view12:31, 4 February 2025EweitzWiden some nodes, rearrange
136480view12:26, 4 February 2025EweitzOntology Term : 'neuron' added !
136479view12:23, 4 February 2025EweitzWiden some nodes
136478view12:06, 4 February 2025EweitzIncrease font size
136477view12:01, 4 February 2025EweitzEconomize layout
136476view02:02, 4 February 2025EweitzEconomize layout
136475view01:51, 4 February 2025EweitzEconomize layout
136474view01:45, 4 February 2025EweitzEconomize layout
136473view01:37, 4 February 2025EweitzEconomize layout
136472view01:32, 4 February 2025EweitzEconomize layout
136471view01:29, 4 February 2025EweitzEconomize layout
136470view01:25, 4 February 2025EweitzEconomize layout
128389view03:01, 4 February 2024EweitzFix typos, standard case
123917view17:08, 30 August 2022KhanspersModified description
123916view17:07, 30 August 2022KhanspersModified description
123915view17:05, 30 August 2022KhanspersModified description
123914view17:05, 30 August 2022Khanspersremoved old comments
119432view00:38, 29 June 2021Khanspersadded literature references
119431view23:52, 28 June 2021KhanspersModified description
119430view23:51, 28 June 2021KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProductENSG00000137845 (Ensembl)
ADAM17GeneProductENSG00000151694 (Ensembl)
ADRM1GeneProductENSG00000130706 (Ensembl)
AGEsMetaboliteCHEBI:84123 (ChEBI)
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
AMBRA1GeneProductENSG00000110497 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
APAF1GeneProductENSG00000120868 (Ensembl)
APBB1GeneProductENSG00000166313 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProduct324 (Entrez Gene)
APH1AGeneProductENSG00000117362 (Ensembl)
APH1BGeneProductENSG00000138613 (Ensembl)
APOEGeneProductENSG00000130203 (Ensembl)
APP intracellular domainGeneProductP05067 (Uniprot-TrEMBL)
APP processingPathway
APP-C83GeneProductP05067 (Uniprot-TrEMBL)
APP-C99GeneProductP05067 (Uniprot-TrEMBL)
APPGeneProductENSG00000142192 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
ATF4GeneProductENSG00000128272 (Ensembl)
ATF6GeneProductENSG00000118217 (Ensembl)
ATG101GeneProductENSG00000123395 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG13GeneProductENSG00000175224 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG14GeneProductENSG00000126775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2AGeneProductENSG00000110046 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATG2BGeneProductENSG00000066739 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ATP2A1GeneProductENSG00000196296 (Ensembl)
ATP2A2GeneProductENSG00000174437 (Ensembl)
ATP2A3GeneProductENSG00000074370 (Ensembl)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProductENSG00000168646 (Ensembl)
ApoptosisPathwayWP254 (WikiPathways)
BACE1GeneProductENSG00000186318 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BECN1GeneProductENSG00000126581 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BECN2GeneProductENSG00000196289 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
BIDGeneProductENSG00000015475 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
CACNA1CGeneProductENSG00000151067 (Ensembl)
CACNA1DGeneProductENSG00000157388 (Ensembl)
CACNA1FGeneProductENSG00000102001 (Ensembl)
CACNA1SGeneProductENSG00000081248 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CALM2GeneProductENSG00000143933 (Ensembl)
CALM3GeneProductENSG00000160014 (Ensembl)
CALML3GeneProductENSG00000178363 (Ensembl)
CALML4GeneProductENSG00000129007 (Ensembl)
CALML5GeneProductENSG00000178372 (Ensembl)
CALML6GeneProductENSG00000169885 (Ensembl)
CAPN1GeneProductENSG00000014216 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CASP12GeneProductENSG00000204403 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CDK5GeneProductENSG00000164885 (Ensembl)
CDK5R1 / p25GeneProductENSG00000176749 (Ensembl)
CDK5R1 / p35GeneProductENSG00000176749 (Ensembl)
CHRNA7GeneProductENSG00000175344 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CSF1GeneProductENSG00000184371 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CYBBGeneProductENSG00000165168 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Calcium signaling pathwayPathway
Ca²⁺MetaboliteHMDB0000464 (HMDB)
Cu⁺MetaboliteHMDB0000657 (HMDB)
Cx IGeneProduct
Cx IIGeneProduct
Cx IIIGeneProduct
Cx IVGeneProduct
Cx VGeneProduct
DDIT3GeneProductENSG00000175197 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK2GeneProductENSG00000155011 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DKK4GeneProductENSG00000104371 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
DNA damagePathway
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
ERN1GeneProductENSG00000178607 (Ensembl)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
Fe²⁺MetaboliteHMDB0000692 (HMDB)
GAPDHGeneProductENSG00000111640 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GPCRGeneProduct
GPR83GeneProductENSG00000123901 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
GSK3BGeneProductENSG00000082701 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
HRASGeneProductENSG00000174775 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15461
HSD17B10GeneProductENSG00000072506 (Ensembl)
Hydrogen peroxideMetaboliteHMDB0003125 (HMDB)
IDEGeneProductENSG00000119912 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
INSGeneProduct3630 (Entrez Gene)
INSRGeneProductENSG00000171105 (Ensembl)
IP3MetaboliteHMDB0001498 (HMDB)
IRS1GeneProductENSG00000169047 (Ensembl)
IRS2GeneProductENSG00000185950 (Ensembl)
IRS4GeneProductENSG00000133124 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
ITPR2GeneProductENSG00000123104 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
Induction of apoptosisPathwayWP1896 (WikiPathways)
InflammationPathwayWP453 (WikiPathways)
KIF5AGeneProductENSG00000155980 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5BGeneProductENSG00000170759 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KIF5CGeneProductENSG00000168280 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC1GeneProductENSG00000126214 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC2GeneProductENSG00000174996 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC3GeneProductENSG00000104892 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KLC4GeneProductENSG00000137171 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
KRASGeneProductENSG00000133703 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16653
LPLGeneProductENSG00000175445 (Ensembl)
LRP1GeneProductENSG00000123384 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
Lipid peroxidationPathwayWP1878 (WikiPathways)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K7GeneProductENSG00000076984 (Ensembl)
MAP3K5GeneProductENSG00000197442 (Ensembl)
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MAPK9GeneProductENSG00000050748 (Ensembl)
MAPTGeneProductENSG00000186868 (Ensembl)
MCUGeneProductENSG00000156026 (Ensembl)
MMEGeneProductENSG00000196549 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
Modulation of gene expressionPathwayWP1821 (WikiPathways)
NAC fragmentProteinP37840 (Uniprot-TrEMBL)
NAE1GeneProductENSG00000159593 (Ensembl)
NCSTNGeneProductENSG00000162736 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOMetaboliteHMDB0003378 (HMDB)
NOS1GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NOX1GeneProductENSG00000007952 (Ensembl)
NOX4GeneProductENSG00000086991 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18176
NRBF2GeneProductENSG00000148572 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ONOO-MetaboliteHMDB0002179 (HMDB)
Oxidative phosphorylationPathwayWP623 (WikiPathways)
P3 peptideGeneProductP05067 (Uniprot-TrEMBL)
PI3PMetaboliteCHEBI:17283 (ChEBI)
PIK3C3GeneProductENSG00000078142 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIK3CAGeneProductENSG00000121879 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18706
PIK3CBGeneProductENSG00000051382 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74769
PIK3CDGeneProductENSG00000171608 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18707
PIK3R1GeneProductENSG00000145675 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18708
PIK3R2GeneProductENSG00000105647 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18709
PIK3R3GeneProductENSG00000117461 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75669
PIK3R4GeneProductENSG00000196455 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
PIP3MetaboliteHMDB0004249 (HMDB)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductENSG00000101333 (Ensembl)
PPIDGeneProductENSG00000171497 (Ensembl)
PPIFGeneProductENSG00000108179 (Ensembl)
PPP3CAGeneProductENSG00000138814 (Ensembl)
PPP3CBGeneProductENSG00000107758 (Ensembl)
PPP3CCGeneProductENSG00000120910 (Ensembl)
PPP3R1GeneProductENSG00000221823 (Ensembl)
PPP3R2GeneProductENSG00000188386 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PSEN2GeneProductENSG00000143801 (Ensembl)
PSENENGeneProductENSG00000205155 (Ensembl)
PSMA1GeneProduct5682 (Entrez Gene)
PSMA2GeneProduct5683 (Entrez Gene)
PSMA3GeneProduct5684 (Entrez Gene)
PSMA4GeneProduct5685 (Entrez Gene)
PSMA5GeneProduct5686 (Entrez Gene)
PSMA6GeneProduct5687 (Entrez Gene)
PSMA7GeneProduct5688 (Entrez Gene)
PSMA8GeneProductENSG00000154611 (Ensembl)
PSMB1GeneProduct5689 (Entrez Gene)
PSMB2GeneProduct5690 (Entrez Gene)
PSMB3GeneProduct5691 (Entrez Gene)
PSMB4GeneProduct5692 (Entrez Gene)
PSMB5GeneProduct5693 (Entrez Gene)
PSMB6GeneProduct5694 (Entrez Gene) U13393
PSMB7GeneProduct5695 (Entrez Gene)
PSMC1GeneProduct5700 (Entrez Gene)
PSMC2GeneProduct5701 (Entrez Gene)
PSMC3GeneProduct5702 (Entrez Gene)
PSMC4GeneProduct5704 (Entrez Gene)
PSMC5GeneProduct5705 (Entrez Gene)
PSMC6GeneProduct5706 (Entrez Gene)
PSMD12GeneProduct5718 (Entrez Gene)
PSMD13GeneProduct5719 (Entrez Gene)
PSMD14GeneProduct10213 (Entrez Gene)
PSMD1GeneProduct5707 (Entrez Gene)
PSMD2GeneProduct5708 (Entrez Gene)
PSMD3GeneProduct5709 (Entrez Gene)
PSMD4GeneProduct5710 (Entrez Gene)
PSMD6GeneProduct9861 (Entrez Gene)
PSMD7GeneProduct5713 (Entrez Gene)
PSMD8GeneProduct5714 (Entrez Gene)
PSMD9GeneProduct5715 (Entrez Gene)
PTGS2GeneProductENSG00000073756 (Ensembl)
Protein oxidationPathway
RAF1GeneProductENSG00000132155 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110157
RAGEProteinQ15109 (Uniprot-TrEMBL)
RB1CC1GeneProductENSG00000023287 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
RELAGeneProduct5970 (Entrez Gene)
RTN3GeneProductENSG00000133318 (Ensembl)
RTN4GeneProductENSG00000115310 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
SEM1GeneProductENSG00000127922 (Ensembl)
SLC25A31GeneProductENSG00000151475 (Ensembl)
SLC25A4GeneProductENSG00000151729 (Ensembl)
SLC25A5GeneProductENSG00000005022 (Ensembl)
SLC25A6GeneProductENSG00000169100 (Ensembl)
SNCAGeneProductENSG00000145335 (Ensembl)
SuperoxideMetaboliteCHEBI:18421 (ChEBI)
TNFGeneProductENSG00000232810 (Ensembl)
TNFRSF1AGeneProductENSG00000067182 (Ensembl)
TPTEP2-CSNK1EGeneProduct1454 (Entrez Gene)
TRAF2GeneProductENSG00000127191 (Ensembl)
TUBA1AGeneProductENSG00000167552 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1BGeneProductENSG00000123416 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA1CGeneProductENSG00000167553 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3CGeneProductENSG00000198033 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3DGeneProductENSG00000075886 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA3EGeneProductENSG00000152086 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA4AGeneProductENSG00000127824 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBA8GeneProductENSG00000183785 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBAL3GeneProductENSG00000178462 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB1GeneProductENSG00000101162 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2AGeneProductENSG00000137267 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB2BGeneProductENSG00000137285 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB3GeneProductENSG00000258947 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4AGeneProductENSG00000104833 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB4BGeneProductENSG00000188229 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB6GeneProductENSG00000176014 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBB8GeneProductENSG00000261456 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
TUBBGeneProductENSG00000196230 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK1GeneProductENSG00000177169 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
ULK2GeneProductENSG00000083290 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
VDAC1GeneProductENSG00000213585 (Ensembl)
VDAC2GeneProductENSG00000165637 (Ensembl)
VDAC3GeneProductENSG00000078668 (Ensembl)
WIPI1GeneProductENSG00000070540 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WIPI2GeneProductENSG00000157954 (Ensembl)
  • SOS1; son of sevenless homolog 1 (Drosophila)
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26413
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
Wnt signaling pathwayPathwayWP428 (WikiPathways)
XBP1GeneProductENSG00000100219 (Ensembl)
beta-amyloid protein 40MetaboliteCHEBI:64646 (ChEBI)
beta-amyloid protein 42MetaboliteCHEBI:64647 (ChEBI)
p50 ATF6GeneProductENSG00000118217 (Ensembl)
sAPP alphaGeneProductP05067 (Uniprot-TrEMBL)
sAPP betaGeneProductP05067 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5124"
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