Sodium channel in Epilepsy (Homo sapiens)

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Description

This pathway illustrates the mechanistic information of sodium channel subtypes. The interactions exclusively focus on neuron electrical regulation. The information provides a roadmap for sodium channel dominanted epilepsygenesis.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
140690view09:07, 7 October 2025DuanUpdate the labels
140678view07:16, 4 October 2025EgonwSmall updates: Ca²⁺ with unicode, removed s stock comment, and updated a datasource
140676view13:35, 2 October 2025Duanchange tissue location to label format
140668view09:18, 30 September 2025Duanupdate the reference
140662view14:46, 29 September 2025DuanUpdate reference
140661view13:13, 29 September 2025DuanCOnnect the un-connected nodes
140660view13:11, 29 September 2025DuanChange the layout
140621view13:57, 19 September 2025DuanModified title
140620view13:56, 19 September 2025DuanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Pathway
-COOHMetaboliteCHEBI:46883 (ChEBI)
2-bromopalmitateMetabolite118417 (ChEBI)
4,9-AnhydrotetrodotoxinMetabolite107878 (PubChem-substance)
AKT1GeneProductENSG00000142208 (Ensembl)
BACE1GeneProductENSG00000186318 (Ensembl)
Benign familial infantile seizures (BFIS)Pathway
Benign familial neonatal-infantile seizures (BFNIS)Pathway
Brain tumor–related epilepsy (BTRE)Pathway
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CNS neurons
CNS neurons in fetal period
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cardiac muscle
Cell adhesionPathway
DNAMetaboliteCHEBI:16991 (ChEBI)
Dravet SyndromePathwayWP5200 (WikiPathways)
Early infantile epileptic encephalopathyPathway
FGF12GeneProductENSG00000114279 (Ensembl)
FGF13GeneProductENSG00000129682 (Ensembl)
FGF14GeneProductENSG00000102466 (Ensembl)
FYNGeneProductENSG00000010810 (Ensembl)
GSK inhibitorsMetaboliteCHEBI:91092 (ChEBI)
GSK3BGeneProductENSG00000082701 (Ensembl)
Genetic epilepsy with febrile seizures plus (GEFS+) Pathway
Heart, uterus, muscle
Ig domain
Intracellular domain (ICD)
JAK2GeneProductENSG00000096968 (Ensembl)
Location
MAPK8IP2GeneProductENSG00000008735 (Ensembl)
NEDD4GeneProductENSG00000069869 (Ensembl)
NEDD4LGeneProductENSG00000049759 (Ensembl)
NFASCGeneProductENSG00000163531 (Ensembl)
Nav1.1ProteinP35498 (Uniprot-SwissProt)
Nav1.2ProteinQ99250 (Uniprot-SwissProt)
Nav1.3ProteinQ9NY46 (Uniprot-SwissProt)
Nav1.4ProteinP35499 (Uniprot-SwissProt)
Nav1.5ProteinQ14524 (Uniprot-SwissProt)
Nav1.6GeneProductENSG00000196876 (Ensembl)
Nav1.6Protein
Nav1.7ProteinQ01118 (Uniprot-SwissProt)
Nav1.8ProteinQ9Y5Y9 (Uniprot-SwissProt)
Nav1.9ProteinQ9UI33 (Uniprot-SwissProt)
NaxProteinQ01118 (Uniprot-SwissProt)
Neuronal migrationPathway
PDCD10GeneProductENSG00000114209 (Ensembl)
PRRT2GeneProductENSG00000167371 (Ensembl)
PSEN1GeneProductENSG00000080815 (Ensembl)
PTPRNGeneProductENSG00000054356 (Ensembl)
Peripheral neurons
RACK1GeneProductENSG00000204628 (Ensembl)
RNF121GeneProductENSG00000137522 (Ensembl)
Rare reflex epilepsyPathway
Reduced action potentialsPathway
Reduced current amplitudePathway
SCN10AGeneProductENSG00000185313 (Ensembl)
SCN11AGeneProductENSG00000168356 (Ensembl)
SCN1A mRNAGeneProductENSG00000144285 (Ensembl)
SCN1AGeneProductENSG00000144285 (Ensembl)
SCN1BGeneProductENSG00000105711 (Ensembl)
SCN2AGeneProductENSG00000136531 (Ensembl)
SCN2BGeneProductENSG00000149575 (Ensembl)
SCN3AGeneProductENSG00000153253 (Ensembl)
  • More GoF[https://www.helbiglab.io/blog/scn3a-a-sodium-channel-in-epilepsy-and-brain-malformations]
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SCN3BGeneProductENSG00000166257 (Ensembl)
SCN4AGeneProductENSG00000007314 (Ensembl)
SCN4BGeneProductENSG00000177098 (Ensembl)
SCN5AGeneProductENSG00000183873 (Ensembl)
SCN7AGeneProductENSG00000136546 (Ensembl)
SCN8A mRNARna
SCN8AGeneProductENSG00000196876 (Ensembl)
SCN9AGeneProductENSG00000169432 (Ensembl)
SCNM1GeneProductENSG00000163156 (Ensembl)
Skeletal muscle
TNFGeneProductENSG00000232810 (Ensembl)
TatCN21Metabolite
Transcription regulationPathway
TriciribineMetaboliteQ25326616 (Wikidata)
UbiquitinationPathway
Voltage-gated Na+ channel(VGSC)Complex
WEE1GeneProductENSG00000166483 (Ensembl)
camrelizumabMetaboliteQ60785565 (Wikidata)
cannabidiolMetaboliteCHEBI:69478 (ChEBI)
developmental and epileptic encephalopathy (DEE)Pathway
early-infantile epileptic encephalopathies (EIEE) 13Pathway
infliximabMetaboliteQ415264 (Wikidata)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5598"
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