GABA and glutamate signalling in epileptogenesis (Homo sapiens)

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Description

This pathway is to depict the epilepsygenesis relevant in GABA and Glutamate pathway. The focus is on the transporters and channel proteins relevant to the action potential alteration which can ultimately lead to epilepsy and their interactors with functional outcome alterations.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
142409view14:44, 5 February 2026DuanChange the identifier for [11C]K-2 compound.
142408view14:20, 5 February 2026DuanChange of glutamine to L-glutamine.
142401view13:40, 5 February 2026DuanChange GABRG2 phosphorylation to acetylation by HDAC.
142400view13:26, 5 February 2026DuanAdded the phosphorylation annotations.
142324view15:51, 5 January 2026Egonwmim-translocation
142140view05:47, 5 December 2025EgonwTypo fix?
142139view05:46, 5 December 2025EgonwMade two pathways clickable
141992view12:50, 29 November 2025EgonwRemoved a stock comment
141991view12:50, 29 November 2025EgonwMore unicode
141667view14:05, 21 November 2025DuanChange the layout
141622view09:56, 20 November 2025DuanAdded reference for not referenced edges
141443view12:38, 14 November 2025DeSlUpdated swissprot to Trembl for better linkouts
141442view12:36, 14 November 2025DeSlUpdated ID for SLC1A3 to reviewed UniProt entry
141179view10:18, 6 November 2025DuanModified title
141167view15:50, 5 November 2025DuanChange the layout
141153view15:24, 4 November 2025DuanModified the layout
141152view15:08, 4 November 2025DuanRearrange the layout
141151view14:55, 4 November 2025DuanModified description
141150view14:54, 4 November 2025DuanModified description
141149view14:52, 4 November 2025DuanModified title
141148view12:05, 4 November 2025DuanAdded more interaction
141094view10:44, 3 November 2025DuanUpdate the pathway
140788view17:23, 28 October 2025DuanAdded more interactions
140783view13:46, 27 October 2025Duanadded more interaction
140782view12:26, 26 October 2025DuanAdd more interactions
140773view19:54, 25 October 2025DuanTo add more interactions.
140772view13:48, 25 October 2025Duanupdate the reference
140771view13:47, 25 October 2025DuanNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABATGeneProductENSG00000183044 (Ensembl)
ADARB1GeneProductENSG00000197381 (Ensembl)
AMPA receptor complexProteinCHEMBL2096670 (EMBL)
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProductENSG00000183020 (Ensembl)
AP2B1GeneProductENSG00000006125 (Ensembl)
ARCGeneProductENSG00000198576 (Ensembl)
ARHGEF9GeneProductENSG00000131089 (Ensembl)
ATAD1GeneProductENSG00000138138 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
C1QL2GeneProductENSG00000144119 (Ensembl)
C1QL3GeneProductENSG00000165985 (Ensembl)
CABIN1GeneProductENSG00000099991 (Ensembl)
CACNG2GeneProductENSG00000166862 (Ensembl)
CACNG8GeneProductENSG00000142408 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CPEB3GeneProductENSG00000107864 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
CRTC1GeneProductENSG00000105662 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl-MetaboliteCHEBI:17996 (ChEBI)
DLG4GeneProductENSG00000132535 (Ensembl)
EFNB2GeneProductENSG00000125266 (Ensembl)
ERBB4GeneProductENSG00000178568 (Ensembl)
FFAR1GeneProductENSG00000126266 (Ensembl)
FRMPD3GeneProductENSG00000147234 (Ensembl)
GABAMetaboliteCHEBI:16865 (ChEBI)
GABRA1GeneProductENSG00000022355 (Ensembl)
GABRA2GeneProductENSG00000151834 (Ensembl)
GABRA3GeneProductENSG00000011677 (Ensembl)
GABRA4GeneProductENSG00000109158 (Ensembl)
GABRA5GeneProductENSG00000186297 (Ensembl)
GABRA6GeneProductENSG00000145863 (Ensembl)
GABRB1GeneProductENSG00000163288 (Ensembl)
GABRB2GeneProductENSG00000145864 (Ensembl)
GABRB3GeneProductENSG00000166206 (Ensembl)
GABRDGeneProductENSG00000187730 (Ensembl)
GABREGeneProductENSG00000102287 (Ensembl)
GABRG1GeneProductENSG00000163285 (Ensembl)
GABRG2GeneProductENSG00000113327 (Ensembl)
GABRG3GeneProductENSG00000182256 (Ensembl)
GABRPGeneProductENSG00000094755 (Ensembl)
GABRQGeneProductENSG00000268089 (Ensembl)
GABRR1GeneProductENSG00000146276 (Ensembl)
GABRR2GeneProductENSG00000111886 (Ensembl)
GABRR3GeneProductENSG00000183185 (Ensembl)
GAD1GeneProductENSG00000128683 (Ensembl)
GAPDHGeneProductENSG00000111640 (Ensembl)
GLS2GeneProductENSG00000135423 (Ensembl)
GLULGeneProductENSG00000135821 (Ensembl)
GNA11GeneProductENSG00000088256 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GRIA1GeneProductENSG00000155511 (Ensembl)
GRIA2GeneProductENSG00000120251 (Ensembl)
GRIA3GeneProductENSG00000125675 (Ensembl)
GRIA4GeneProductENSG00000152578 (Ensembl)
GRIK1GeneProductENSG00000171189 (Ensembl)
GRIK2GeneProductENSG00000164418 (Ensembl)
GRIK3GeneProductENSG00000163873 (Ensembl)
GRIK4GeneProductENSG00000149403 (Ensembl)
GRIK5GeneProductENSG00000105737 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GRIN3AGeneProductENSG00000198785 (Ensembl)
GRIN3BGeneProductENSG00000116032 (Ensembl)
GRIP1GeneProductENSG00000155974 (Ensembl)
GRM1GeneProductENSG00000152822 (Ensembl)
GRM2GeneProductENSG00000164082 (Ensembl)
GRM3GeneProductENSG00000198822 (Ensembl)
GRM4GeneProductENSG00000124493 (Ensembl)
GRM5GeneProductENSG00000168959 (Ensembl)
GRM6GeneProductENSG00000113262 (Ensembl)
GRM7GeneProductENSG00000196277 (Ensembl)
GRM8GeneProductENSG00000179603 (Ensembl)
GluA1GeneProductENSG00000155511 (Ensembl)
GluA2GeneProductENSG00000120251 (Ensembl)
GluA2ProteinP42262 (Uniprot-TrEMBL)
GluN2AGeneProductENSG00000183454 (Ensembl)
GluN2AProteinQ12879 (Uniprot-SwissProt)
GluN2BGeneProductENSG00000273079 (Ensembl)
HDAC10GeneProductENSG00000100429 (Ensembl)
HDAC1GeneProductENSG00000116478 (Ensembl)
HOMER1GeneProductENSG00000152413 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
KIF5CGeneProductENSG00000168280 (Ensembl)
LHFPL4GeneProductENSG00000156959 (Ensembl)
MAP1LC3BGeneProductENSG00000140941 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAPK signalingPathwayWP5530 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MBD5GeneProductENSG00000204406 (Ensembl)
NETO2GeneProductENSG00000171208 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NOSMetaboliteQ417619 (Wikidata)
NPTNGeneProductENSG00000156642 (Ensembl)
NR4A1GeneProductENSG00000123358 (Ensembl)
NRG1GeneProductENSG00000157168 (Ensembl)
NRXN3GeneProductENSG00000021645 (Ensembl)
NWD1GeneProductENSG00000188039 (Ensembl)
Na+MetaboliteCHEBI:29101 (ChEBI)
ORAI1GeneProductENSG00000276045 (Ensembl)
P4HBGeneProductENSG00000185624 (Ensembl)
PDIA2GeneProductENSG00000185615 (Ensembl)
PI3K-AktPathwayWP4172 (WikiPathways)
PICK1GeneProductENSG00000100151 (Ensembl)
PLCB1GeneProductENSG00000182621 (Ensembl)
PPP2CAGeneProductENSG00000113575 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
SDCBPGeneProductENSG00000137575 (Ensembl)
SH3GL2GeneProductENSG00000107295 (Ensembl)
SLC12A5GeneProductENSG00000124140 (Ensembl)
SLC1A1GeneProductENSG00000106688 (Ensembl)
SLC1A2GeneProductENSG00000110436 (Ensembl)
SLC1A3ProteinA0A024R050 (Uniprot-TrEMBL)
SLC1A6GeneProductENSG00000105143 (Ensembl)
SLC1A7GeneProductENSG00000162383 (Ensembl)
SLC32A1GeneProductENSG00000101438 (Ensembl)
SLC6A11GeneProductENSG00000132164 (Ensembl)
SLC6A12GeneProductENSG00000111181 (Ensembl)
SLC6A13GeneProductENSG00000010379 (Ensembl)
SLC6A1GeneProductENSG00000157103 (Ensembl)
SLC6A6GeneProductSLC6A6 (HGNC)
SLC6A8GeneProductENSG00000130821 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SNX14GeneProductENSG00000135317 (Ensembl)
SNX27GeneProductENSG00000143376 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STIM1GeneProductENSG00000167323 (Ensembl)
SUMO1GeneProductENSG00000116030 (Ensembl)
SYVN1GeneProductENSG00000162298 (Ensembl)
Succinic semialdehydeMetaboliteCHEBI:16265 (ChEBI)
TCA cycle PathwayWP78 (WikiPathways)
UBP310MetaboliteCHEMBL373428 (ChEMBL compound)
UBQLN4GeneProductENSG00000160803 (Ensembl)
ZFYVE27GeneProductENSG00000155256 (Ensembl)
[11C]K-2MetaboliteDUUIMJHPKHJBPZ-BJUDXGSMSA-N (InChIKey)
cystineMetaboliteCHEBI:17376 (ChEBI)
downregulationProteinCHEMBL2096670 (EMBL)
glutamateMetaboliteCHEBI:14321 (ChEBI)
glutamineMetaboliteCHEBI:28300 (ChEBI)
succinateMetaboliteCHEBI:30031 (ChEBI)
upregulationProteinCHEMBL2096670 (EMBL)
α-ketoglutarateMetaboliteCHEBI:16810 (ChEBI)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5600"