Endochondral ossification (Homo sapiens)

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1, 2WNT signalingcanonical / non-canonicalBMPsHypertrophyProliferationCathepsinsand CalpainsChondrocyte proliferationRemoval of extracellular matrixand invasion by bone cellsChondrocyte (pre)hypertrophyOsteoblasticdifferentiation?CartilageintegrinsBoneFull differentiationMineralisationDyingVascular invastionRemoval of cartilage matrixChondrocyte deathFrzB-1COL2A1cAMPTriiodothyronineFGF18TGFB2BMPR1ATGFB1OxygenSox6FGFR1ADAMTS5FGFR3TG737AdseverinHMGCS1SERPINH1PLAUBapx1PTHrPTNAPMMP9CALM1GH receptorC4ST1Growth hormoneBMP6RUNX2PKASLC38A2Thyroid hormoneAKTSox5KIF3APTCH1SPP1STAT1AggrecanMEF2CNPP1PTCHTHRAPTHR1IGF1RDDR2IGF1COL10A1FGF2CAB39TIMP3RUNX2ADAMTS4HDAC4PTHADAMTS1PLATIHHTGFBICDKN1CMGPOsteopontinAKP2GsIGF2RUNX2MMP13STAT5GLI3CarminerinSox9Cathepsin L2Thyroid hormoneRUNX3BMP7THRAVEGFA


Description

No description

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Quality Tags

Ontology Terms

 

Bibliography

  1. Belluoccio D, Bernardo BC, Rowley L, Bateman JF; ''A microarray approach for comparative expression profiling of the discrete maturation zones of mouse growth plate cartilage.''; Biochim Biophys Acta, 2008 PubMed Europe PMC Scholia
  2. Mackie EJ, Ahmed YA, Tatarczuch L, Chen KS, Mirams M; ''Endochondral ossification: how cartilage is converted into bone in the developing skeleton.''; Int J Biochem Cell Biol, 2008 PubMed Europe PMC Scholia
  3. Randau TM, Schildberg FA, Alini M, Wimmer MD, Haddouti el-M, Gravius S, Ito K, Stoddart MJ; ''The effect of dexamethasone and triiodothyronine on terminal differentiation of primary bovine chondrocytes and chondrogenically differentiated mesenchymal stem cells.''; PLoS One, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128904view00:46, 24 February 2024EweitzStandardize case
128903view00:46, 24 February 2024EweitzFix typo, standardize case
117098view11:31, 17 May 2021EweitzModified title
106812view13:29, 17 September 2019MaintBotHMDB identifier normalization
106400view21:31, 28 August 2019KhanspersModified description
105580view06:42, 9 August 2019KhanspersModified description
95499view13:36, 18 December 2017DeSlAdded additional literature reference, changed unconnected lines to graphical lines.
95498view13:33, 18 December 2017DeSlModified description
95497view13:32, 18 December 2017DeSlModified description
95220view17:50, 26 November 2017DeSlChanged unconnected lines to graphical lines (where applicable).
87977view13:18, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80208view20:59, 22 May 2015KhanspersReverted to version '05:03, 25 October 2013' by Khanspers
80164view21:19, 14 May 2015KhanspersAdded mir499a targeting of SOX6
72122view05:03, 25 October 2013EgonwAdded missing metabolite identifiers.
63180view20:42, 8 May 2013MaintBotUpdating gpml version
45241view18:23, 7 October 2011AlexanderPicoOntology Term : 'osteochondroclast' added !
45003view15:53, 6 October 2011LarsEijssenOntology Term : 'osteoclast' added !
45001view15:52, 6 October 2011LarsEijssenOntology Term : 'chondrocyte' added !
45000view15:47, 6 October 2011LarsEijssenModified description
44999view14:45, 6 October 2011LarsEijssenadapted types of groups where relevant
41222view23:45, 1 March 2011MaintBotRemoved redundant pathway information and comments
32442view17:18, 15 August 2009MaintBotFixed text labels
32115view13:50, 14 August 2009MaintBotFixed group labels
29737view22:33, 1 June 2009KhanspersModified categories
28899view15:55, 11 March 2009AllaPeriodical save, work in progress
21676view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:Endochondral Ossification]] moved to [[Pathway:WP474]]: Moved to stable identifier
19039view11:03, 16 September 2008LarsEijssenTwo genes changed to CAPS
19033view09:44, 16 September 2008LarsEijssenadded some missing Entrez gene IDs, removed a duplicate gene SPP1, changed Gs into label
16584view19:30, 22 June 2008AlexanderPicoconnected example nodes to database
16120view12:00, 11 June 2008LarsEijssenfixed data node types
16118view11:28, 11 June 2008LarsEijssenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAMTS1GeneProduct9510 (Entrez Gene)
ADAMTS4GeneProduct9507 (Entrez Gene)
ADAMTS5GeneProduct11096 (Entrez Gene)
AKP2GeneProduct
AKTUnknown207 (Entrez Gene)
AdseverinGeneProduct85477 (Entrez Gene) PMID: 17097081
AggrecanGeneProduct176 (Entrez Gene)
BMP6Unknown654 (Entrez Gene)
BMP7Unknown655 (Entrez Gene)
BMPR1AUnknown657 (Entrez Gene)
Bapx1GeneProduct579 (Entrez Gene)
C4ST1GeneProduct50515 (Entrez Gene)
CAB39GeneProduct
CALM1GeneProduct
CDKN1CGeneProduct
COL10A1Unknown1300 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
CarminerinUnknown1473 (Entrez Gene)
  • Taken as human homologue of mouse Cst10
  • PMID: 13679380
Cathepsin L2GeneProduct1515 (Entrez Gene) Taken as homologue to mouse Cathepsin L (Ctsl)
DDR2GeneProduct4921 (Entrez Gene)
FGF18GeneProduct8817 (Entrez Gene)
FGF2GeneProduct2247 (Entrez Gene)
FGFR1GeneProduct
FGFR3GeneProduct
FrzB-1GeneProduct2487 (Entrez Gene)
GH receptorUnknown2690 (Entrez Gene)
GLI3Unknown2737 (Entrez Gene)
Growth hormoneUnknown2688 (Entrez Gene)
GsUnknown
HDAC4GeneProduct9759 (Entrez Gene)
HMGCS1GeneProduct
IGF1Unknown3479 (Entrez Gene)
IGF1RUnknown3480 (Entrez Gene)
IGF2Unknown3481 (Entrez Gene)
IHHUnknown3549 (Entrez Gene)
KIF3AUnknown11127 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MGPGeneProduct
MMP13GeneProduct4322 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
NPP1Unknown5167 (Entrez Gene)
OsteopontinUnknown6696 (Entrez Gene)
OxygenMetaboliteO2
PKAUnknown5566 (Entrez Gene)
PLATGeneProduct5327 (Entrez Gene)
PLAUGeneProduct5328 (Entrez Gene)
PTCH1GeneProduct
PTCHUnknown5727 (Entrez Gene)
PTHUnknown5741 (Entrez Gene)
PTHR1Unknown5745 (Entrez Gene)
PTHrPUnknown5744 (Entrez Gene)
RUNX2Unknown860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINH1GeneProduct
SLC38A2GeneProduct
SPP1GeneProduct
STAT1GeneProduct6772 (Entrez Gene)
STAT5Unknown6777 (Entrez Gene)
Sox5GeneProduct6660 (Entrez Gene)
Sox6GeneProduct55553 (Entrez Gene)
Sox9Unknown6662 (Entrez Gene)
TG737Unknown8100 (Entrez Gene)
TGFB1Unknown7040 (Entrez Gene)
TGFB2Unknown7042 (Entrez Gene)
TGFBIGeneProduct
THRAUnknown7067 (Entrez Gene)
TIMP3GeneProduct
TNAPUnknown445341 (Entrez Gene)
Thyroid hormoneMetaboliteT4
TriiodothyronineMetaboliteT3
VEGFAUnknown7422 (Entrez Gene)
cAMPUnknown

Annotated Interactions

No annotated interactions

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