Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs) (Homo sapiens)

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Endoplasmic reticulumSubstrate-OFADH+NADP+FMO5H2OO2NADP+FAD-OHNADP+FADH2FMO4FADNADPHFAD-OOHSubstrateFMO2NADP+NADP+FMO1FMO3


Description

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Ontology Terms

 

Bibliography

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  1. Elfarra AA, Krause RJ; ''Potential roles of flavin-containing monooxygenases in sulfoxidation reactions of l-methionine, N-acetyl-l-methionine and peptides containing l-methionine.''; Biochim Biophys Acta, 2005 PubMed Europe PMC Scholia
  2. Krueger SK, Williams DE; ''Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.''; Pharmacol Ther, 2005 PubMed Europe PMC Scholia
  3. Ziegler DM; ''Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity.''; Trends Pharmacol Sci, 1990 PubMed Europe PMC Scholia
  4. Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM; ''The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression.''; Toxicol Appl Pharmacol, 1994 PubMed Europe PMC Scholia
  5. Poulsen LL, Ziegler DM; ''Multisubstrate flavin-containing monooxygenases: applications of mechanism to specificity.''; Chem Biol Interact, 1995 PubMed Europe PMC Scholia
  6. Phillips IR, Shephard EA; ''Flavin-containing monooxygenases: mutations, disease and drug response.''; Trends Pharmacol Sci, 2008 PubMed Europe PMC Scholia
  7. Cashman JR; ''Some distinctions between flavin-containing and cytochrome P450 monooxygenases.''; Biochem Biophys Res Commun, 2005 PubMed Europe PMC Scholia
  8. Cashman JR, Zhang J; ''Human flavin-containing monooxygenases.''; Annu Rev Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117673view11:59, 22 May 2021EweitzModified title
107912view09:33, 10 November 2019EgonwReplaced a sub-optimal PubChem CID with a ChEBI identifier.
106823view13:30, 17 September 2019MaintBotHMDB identifier normalization
94198view14:44, 25 August 2017DeSlAdded ID for FAD-OH
94195view14:38, 25 August 2017DeSlChanged metabolite nodes into textlabels, since they were not metabolites.
84769view16:25, 17 March 2016EveloModified title
79222view13:47, 15 March 2015EgonwReplaced the HMDB H2 identifier with H+ from ChEBI.
63157view20:18, 8 May 2013MaintBotUpdating gpml version
59115view22:27, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48246view06:16, 17 May 2012MaintBotUpdating PubChem xrefs
44984view14:33, 6 October 2011MartijnVanIerselOntology Term : 'cellular detoxification pathway' added !
41065view23:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34638view19:41, 7 January 2010KhanspersModified categories
33407view14:49, 30 November 2009MaintBotRemoved group label
30258view04:47, 25 July 2009AlexanderPicoModified categories
29954view06:26, 15 June 2009Pieter GiesbertzSpecify description
29591view11:49, 19 May 2009Pieter GiesbertzAdded datanodes
29590view10:26, 19 May 2009Pieter GiesbertzModified description
29507view07:54, 11 May 2009Pieter GiesbertzAdded literature reference
29506view07:26, 11 May 2009Pieter GiesbertzAdded literature references
29290view08:53, 22 April 2009Pieter GiesbertzSpecify description
29280view07:38, 22 April 2009Pieter GiesbertzSpecify description
29255view11:29, 20 April 2009Pieter GiesbertzSpecify description
29234view07:57, 17 April 2009Pieter GiesbertzSpecify description
29155view10:52, 8 April 2009Pieter GiesbertzSpecify description
29151view09:57, 7 April 2009Pieter GiesbertzSpecify description
29150view09:56, 7 April 2009Pieter GiesbertzSpecify description
29107view14:14, 2 April 2009Pieter GiesbertzSpecify description
29106view14:12, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29105view14:01, 2 April 2009Pieter GiesbertzSpecify description
29104view12:08, 2 April 2009Pieter GiesbertzSpecify description
29103view11:57, 2 April 2009Pieter GiesbertzSpecify description
29102view11:56, 2 April 2009Pieter GiesbertzSpecify description
29101view11:50, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29100view11:42, 2 April 2009Pieter GiesbertzSpecify description
29099view11:33, 2 April 2009Pieter GiesbertzSpecify description
29098view11:19, 2 April 2009Pieter GiesbertzSpecify description
29097view10:51, 2 April 2009Pieter GiesbertzSpecify description
29096view09:32, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29095view09:22, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29094view09:10, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29093view08:57, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29092view08:46, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29091view08:06, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29090view07:31, 2 April 2009Pieter GiesbertzPeriodical save, work in progress
29081view14:56, 31 March 2009Pieter GiesbertzCatalytic cycle of mammalian FMOs
29080view14:48, 31 March 2009Pieter GiesbertzPeriodical save, work in progress
29079view14:38, 31 March 2009Pieter GiesbertzNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
FAD-OHMetabolite
FAD-OOHMetabolite
FADH2Metabolite
FADMetaboliteHMDB01248 (HMDB)
FMO1GeneProductENSG00000010932 (Ensembl)
FMO2GeneProductENSG00000094963 (Ensembl)
FMO3GeneProductENSG00000007933 (Ensembl)
FMO4GeneProductENSG00000076258 (Ensembl)
FMO5GeneProductENSG00000131781 (Ensembl)
H+MetaboliteHMDB01362 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
NADP+Metabolite
NADP+MetaboliteHMDB00217 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
SubstrateMetabolite
Substrate-OMetabolite

Annotated Interactions

No annotated interactions

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