Heme biosynthesis (Homo sapiens)

From WikiPathways

Description

Quality Tags

Ontology Terms

Bibliography

1. Polo CF, Vazquez ES, Caballero F, Gerez E, Battle AM; ''Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation.''; Comp Biochem Physiol B, 1992 PubMed Europe PMC Scholia

History

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Compare	Revision	Action	Time	User	Comment
	124939	view	11:06, 2 January 2023	Egonw	Removed incorrect license info
	124938	view	11:05, 2 January 2023	Egonw	Fixed coloring of two metabolites
	117151	view	09:44, 18 May 2021	Eweitz	Modified title
	107186	view	14:27, 17 September 2019	MaintBot	ChEBI identifier normalization
	106818	view	13:29, 17 September 2019	MaintBot	HMDB identifier normalization
	102939	view	09:48, 30 January 2019	Egonw	Made another label a Metabolite, and annotated with MIM some of the interaction (catalyses).
	93014	view	15:05, 24 July 2017	DeSl	Changed (vague) CAS to ChEBI ID (which looked to be more relevant).
	89918	view	13:32, 6 October 2016	Mkutmon	Modified description
	72035	view	13:30, 24 October 2013	Mkutmon	fixed unconnected lines
	70993	view	21:11, 21 September 2013	Egonw	Converted two metabolites from Label to Metabolite.
	70636	view	09:52, 20 August 2013	Egonw	Converted a combined label into a DataNode.
	70635	view	09:46, 20 August 2013	Egonw	Converted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.
	70093	view	18:34, 12 July 2013	MaintBot	updating to 2013 schema
	45350	view	20:27, 7 October 2011	AlexanderPico	Ontology Term : 'hematopoietic cell' added !
	45349	view	20:26, 7 October 2011	AlexanderPico	Ontology Term : 'bone marrow cell' added !
	45347	view	20:25, 7 October 2011	AlexanderPico	Ontology Term : 'heme biosynthetic pathway' added !
	41027	view	23:13, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	38913	view	20:50, 24 September 2010	Khanspers
	37761	view	18:57, 1 July 2010	Khanspers	Changed representation of enzymes
	35633	view	19:10, 12 February 2010	Andra	Added references
	35284	view	22:46, 11 February 2010	Mills42	Modified description
	34432	view	18:14, 10 December 2009	MaintBot	Automatic update of empty xrefs
	32151	view	14:01, 14 August 2009	MaintBot	Fixed group labels
	21860	view	11:32, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:Heme Biosynthesis]] moved to [[Pathway:WP561]]: Moved to stable identifier
	15407	view	23:07, 27 May 2008	Khanspers	connectors fix
	14725	view	21:51, 23 May 2008	Khanspers	test
	14721	view	21:47, 23 May 2008	Khanspers	Removed stochiometry
	14524	view	01:31, 23 May 2008	Khanspers	Added metabolites
	14519	view	01:24, 23 May 2008	Khanspers	Added connectors, metabolites
	14508	view	01:14, 23 May 2008	Khanspers	Periodical save, work in progress
	13079	view	11:14, 17 May 2008	MaintBot	automated metabolite conversion
	8132	view	13:46, 7 January 2008	MaintBot	[[Pathway:Human:Heme Biosynthesis]] moved to [[Pathway:Homo sapiens:Heme Biosynthesis]]: Renaming species
	7687	view	16:09, 18 December 2007	MaintBot	fixed category names
	7372	view	12:42, 4 November 2007	MaintBot	Added categories to GPML
	6332	view	22:17, 22 May 2007	Kdahlquist	gpml file for [[Human:Heme_Biosynthesis]]

External references

DataNodes

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Name	Type	Database reference	Comment
ALAD	GeneProduct	210 (Entrez Gene)
ALAS1	GeneProduct	211 (Entrez Gene)
ALAS2	GeneProduct	212 (Entrez Gene)
CO2	Metabolite	HMDB01967 (HMDB)
CPOX	GeneProduct	1371 (Entrez Gene)
CoA	Metabolite	HMDB01423 (HMDB)
FECH	GeneProduct	2235 (Entrez Gene)
H2O2	Metabolite	HMDB03125 (HMDB)
H2O	Metabolite	HMDB02111 (HMDB)
HMBS	GeneProduct	3145 (Entrez Gene)
NH3	Metabolite	HMDB00051 (HMDB)
O2	Metabolite	HMDB01377 (HMDB)
PPOX	GeneProduct	5498 (Entrez Gene)
Porphobilinogen	Metabolite	HMDB00245 (HMDB)
UROD	GeneProduct	7389 (Entrez Gene)
UROS	GeneProduct	7390 (Entrez Gene)
coproporphyrinogen III	Unknown	2624-63-7 (CAS)
hydroxymethylbilane	Unknown	73023-76-4 (CAS)
porphobilinogen	Unknown	487-90-1 (CAS)
protoheme	Unknown	14875-96-8 (CAS)
protoporphyrin IX	Unknown	553-12-8 (CAS)
uroporphyrinogen III	Unknown	1976-85-8 (CAS)

Annotated Interactions

No annotated interactions