TNF-alpha NF-kB signaling pathway (Gallus gallus)

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EndosomeEndoplasmic reticulum(Protein-protein interaction)ERRecruitmentDeacetylationDemethylationProteolytic cleavageProteins in a complex interactionDesumoylationENCY ->NUInhibitionCY ->NUEnzyme complexDDeubiquitinationMitochondrionLigandPMAccession Number: NetPath 9; cellmap:9AcetylationGolgi apparatusTranslocationCY ->NUCytoplasmMolecular associationMolecule in the pathwayGlycosylationUbiquitinationCY ->NUControlPalmitoylationMethylationMTNUECGOReceptorSumoylationExtracellularReaction through unknown mechanisms/moleculesCY ->NUAutophosphorylationDephosphorylationPlasma membraneNucleusActivationPhosphorylationCYRCJMB04_2a4G3BP2TXLNACASP7CRADDRCJMB04_11l21NR2C2RELTNFRSF1BRASAL2TNFRSF11ABCL3RELAMAP3K7IP1TRAF5HSPCBMTIF2BIRC2TANKFANCD2RPL30NFKBIEGNB2L1Gene SymbolSMARCC1RCJMB04_19h23CDC37TRAF4RCJMB04_36h7UBCH5CRPL6NFKBIACASP8AP2TRAF3POLR1DRCJMB04_14f8NFKB1NFKB2FBLRCJMB04_4j14PTK2PPP2CAPOLR1ATNFYWHAECOMMD1SMARCE1CUL1CDC34FAF1NFKBIAGeneCAPN3PSMD13ALPLHDAC1PDCD2POLR1ETRAF4HSP90AA1TNIP1NKIRAS2PSMD7TRAF1PKN1GeneMCM5LRPPRCFLNAIKBKGIKBKGRIPK2BAG4TBK1PRKACARELBCASP2MAP3K2RIPK1TNFTNFRSF1AMAP3K1NFKB1PEG3RIPK3AKT2KPNA3RCJMB04_19h23POLR1CCFLARRPS13IKBKEHDAC6PIAS3DBC1TNIP2RCJMB04_5e12TIFATRAF6PSMC3GeneRIPK1YWHABGSK3BRPL4CASP3MAP3K8PFDN2NSMAFGAB1CSNK2BNALP4NFKBIARCJMB04_34f17PSMB5MAP3K14CYLDCASP10KPNA2FADDIQGAP2PSMD6PSMC1TNFKCNQ1CSNK2A2AKT1RCJMB04_17o18TRPC4APBIRC2RELATNFMARK2YWHAQNKIRAS1TRAF2SMARCA4EIF4A3MAP3K3PRKCZGLG1IKBKBTNFRSF1ATNFRSF1BHDAC2MAP3K7IP3BCL7ACREBBPTRAF1COPS3MCCPAPOLATNFUSP11MAP3K3RELBGTF2IMCM7TNFRSF8RPS6KA5PTPN11CSNK2A1PEBP1USP2WDR68DAPSMARCC2RELABIRC3KTN1AZI2RNF216HIST3H3SRCTRAIPRPS11DPF2ZFAND5PSMD3CAV1RNF25TRADDSKP1ATRAF2SUMO1ACTL6AASE1BIRC3YWHAHTRAF2UBE2IGenePPP1R13LTNFNFKBIZCASP8RCJMB04_17i9POLR1BMAP3K7IP2RELTNFRSF1APOLR2HPSMC2NFKB1NFKBIBTRADDSMARCB1HSPB1PSMD1AKAP8PMLRELAPOLR2LNR2C2PSMD12RPL8TBK1UNC5CLTNFRSF1BFKBP5TNFAIP3BTRCUBE2D2


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 69% conversion rate.

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History

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CompareRevisionActionTimeUserComment
118011view11:32, 23 May 2021EweitzModified title
108152view10:37, 29 November 2019FehrhartOntology Term : 'cancer' added !
87787view11:14, 25 July 2016MirellaKalafatiOntology Term : 'cancer pathway' added !
87785view11:13, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
68867view17:21, 8 July 2013MaintBotUpdated to 2013 gpml schema
41006view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
33927view18:09, 9 December 2009MaintBotAutomatic update of empty xrefs
33485view15:08, 30 November 2009MaintBotRemoved group label
31535view21:45, 13 August 2009MaintBotFixed text labels
30380view21:02, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKAP8GeneProduct426167 (Entrez Gene)
AKT1GeneProduct395928 (Entrez Gene)
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BAG4GeneProduct426776 (Entrez Gene)
BCL3GeneProduct
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CAPN3GeneProduct423233 (Entrez Gene)
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CSNK2A1GeneProduct432370 (Entrez Gene)
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FBLGeneProduct
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FLNAGeneProduct
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RCJMB04_11l21GeneProduct425619 (Entrez Gene)
RCJMB04_14f8GeneProduct419656 (Entrez Gene)
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RCJMB04_17o18GeneProduct427375 (Entrez Gene)
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TNFAIP3GeneProduct
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TNFRSF1AGeneProduct
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TNIP1GeneProduct
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YWHAQGeneProduct
ZFAND5GeneProduct427254 (Entrez Gene)

Annotated Interactions

No annotated interactions
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