Heme biosynthesis (Bos taurus)

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delta-aminolevulinaterate limiting stepsuccinyl-CoA + glycineRed - side productsFe2+delta-aminolevulinateprotoporphyrinogen IXH+Black - reactantsPPOXCO2protohemeO2H2OCO2CoAALAS2ALADO2FECHNH3URODuroporphyrinogen IIIPorphobilinogenporphobilinogenH2O2CPOXHMBShydroxymethylbilanecoproporphyrinogen IIIUROSH2Oprotoporphyrin IXCO2ALAS1H2O


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP561(r21860) with a 60% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Polo CF, Vazquez ES, Caballero F, Gerez E, Battle AM; ''Heme biosynthesis pathway regulation in a model of hepatocarcinogenesis pre-initiation.''; Comp Biochem Physiol B, 1992 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117542view11:15, 21 May 2021EweitzModified title
107076view14:16, 17 September 2019MaintBotChEBI identifier normalization
105974view11:50, 16 August 2019MaintBotHMDB identifier normalization
93012view15:00, 24 July 2017DeSlChanged (vague) CAS to ChEBI ID (which looked to be more relevant).
89919view13:32, 6 October 2016MkutmonModified description
80842view15:28, 30 June 2015Mkutmonhomology conversion
79163view05:17, 6 March 2015MaintBotUpdated conversion from Hs
71851view20:12, 18 October 2013MaintBotremoved data source from nodes without identifier
63475view17:20, 10 May 2013MaintBotupdating gpml
40576view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35292view22:54, 11 February 2010Mills42Modified description
33814view00:22, 9 December 2009MaintBotAutomatic update of empty xrefs
33616view10:01, 1 December 2009MaintBotRemoved group label
30536view21:55, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ALADGeneProduct510679 (Entrez Gene)
ALAS1GeneProduct534286 (Entrez Gene)
ALAS2GeneProduct511791 (Entrez Gene)
CO2MetaboliteHMDB01967 (HMDB)
CPOXGeneProduct540283 (Entrez Gene)
CoAMetaboliteHMDB01423 (HMDB)
FECHGeneProduct281158 (Entrez Gene)
H2O2MetaboliteHMDB03125 (HMDB)
H2OMetaboliteHMDB02111 (HMDB)
HMBSGeneProduct515614 (Entrez Gene)
NH3MetaboliteHMDB00051 (HMDB)
O2MetaboliteHMDB01377 (HMDB)
PPOXGeneProduct515770 (Entrez Gene)
PorphobilinogenMetaboliteHMDB00245 (HMDB)
URODGeneProduct504914 (Entrez Gene)
UROSGeneProduct613425 (Entrez Gene)
coproporphyrinogen IIIMetabolite
hydroxymethylbilaneMetabolite
porphobilinogenMetabolite
protohemeMetabolite
protoporphyrin IXMetabolite
uroporphyrinogen IIIMetabolite

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP967"
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