DNA replication (Drosophila melanogaster)

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CTPCdc6Pre-replicative complexADPOrc23. DNA replication initiationDegraded by proteasome in cytosolRNA primer-DNA primer:origin duplex:PCNAp70Mcm6Mcm10ATPdUTPRFC37p49dGTPOrc3aRFC36Phosphorylated Orc1ATPADPUbiquitin4. Switching of origins to post-replicative stateRFC Heteropentamer:RNA primer-DNA primer:RFC140UTPDegraded by proteasome in cytosolOrc5PCNA homotrimerMcm 4,6,7 trimer forms and associatesMcm5Mcm7Orc2RNA primer-DNA primerMcm4p58DNA polymerase alpha: primase: origin complexPhosphorylation of Mcm 2-7 complexATPPre-replicative complexMcm4ATPDNA PolymeraseUbiquitinated Orc1Mcm3Cdc6Orc4RFC Heteropentamer:RNA primer-DNA primerRNA primer-DNA primerOrc complexUbiquitinOrc2RNA PrimerRFC38Mcm2p180DNA polymerase alpha: primase: origin complexdATPOriginGemininOrc5Mcm2dCTPOrc ComplexOrc3Orc5Orc complexOrc3Orc41. Assembly of the pre-replicative complexOrc2Mcm7Cdc6Cdt1Orc3Cdt1GTPProcessive complexOrc complexCdt1RFC40Cdt1Cdc6HOMOLOGY MAPPMcm5Cdt1Mcm6Primase5. Leading/lagging strand synthesisPhosphorylated Cdc6Orc complexwith the replication fork2. Activation of the pre-replicative complexUbiquitinated Cdc6Orc1Mcm3latdupDNAprimRpA-70CG9273RpL40Orc2Orc1Ubi-p63EASKOrc6Pole2GMNNl(1)G0148RPA4RfC3Orc4DNApol-deltaDNApol-alpha73Orc5mus209POLD3Mcm6RfC38Mcm10DNApol-alpha50CDC45LMcm2POLD4Gnf1RfC40DNApol-epsilonRPA3Mcm5CG12018DNApol-alpha180CG8142Mcm3CDK2Mcm7CG5971dpa


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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