DNA replication (Drosophila melanogaster)

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UTPMcm23. DNA replication initiationp58Orc21. Assembly of the pre-replicative complexRNA primer-DNA primerDNA PolymeraseRFC364. Switching of origins to post-replicative statePhosphorylation of Mcm 2-7 complexPhosphorylated Cdc6Phosphorylated Orc1RFC40p70dATPATP2. Activation of the pre-replicative complexRFC38ATPdCTPUbiquitinated Orc1Orc2Orc complexPrimaseUbiquitinRNA PrimerRNA primer-DNA primerOrc2RNA primer-DNA primer:origin duplex:PCNAwith the replication forkHOMOLOGY MAPPCdc6Cdc6ADPMcm7p180CTPDNA polymerase alpha: primase: origin complexRFC Heteropentamer:RNA primer-DNA primer:Mcm2Mcm7p49Pre-replicative complexDegraded by proteasome in cytosolMcm6Cdt1Cdc6PCNA homotrimerATPOrc complexADPOrc5dGTPRFC140Mcm4RFC37GTPUbiquitinOrc2Cdt1Orc1Mcm4dUTPCdt1Orc4Orc3Mcm5Orc5Orc3Mcm3RFC Heteropentamer:RNA primer-DNA primer5. Leading/lagging strand synthesisMcm10Cdc6Orc4GemininATPOrc complexMcm5Cdt1Mcm 4,6,7 trimer forms and associatesMcm3Cdt1OriginOrc3DNA polymerase alpha: primase: origin complexOrc ComplexaProcessive complexUbiquitinated Cdc6Orc complexOrc3Pre-replicative complexDegraded by proteasome in cytosolOrc5Mcm6RPA3Orc5Mcm6DNApol-epsilonCG12018Mcm5Orc4GMNNRpA-70duplatRpL40CDC45LDNApol-alpha50RfC38Orc6Ubi-p63ECG8142CG9273Orc1l(1)G0148DNApol-deltadpaGnf1RPA4DNApol-alpha73Pole2POLD3Mcm10CG5971ASKmus209Orc2DNApol-alpha180Mcm3POLD4DNAprimRfC40Mcm7RfC3CDK2Mcm2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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