DNA replication (Drosophila melanogaster)

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1, 2UbiquitinDNA polymerase alpha: primase: origin complexOrc ComplexOrc complexOrc3GTPUbiquitinMcm10Orc2Ubiquitinated Cdc6Processive complexOrc4Orc22. Activation of the pre-replicative complexCdt1DNA polymerase alpha: primase: origin complexOrc5Orc2Degraded by proteasome in cytosolCdt1Orc5Pre-replicative complexCdc6Orc4p70Mcm6Mcm2DNA PolymerasedATPMcm3dGTPMcm5Orc5GemininUTPUbiquitinated Orc1OriginPhosphorylation of Mcm 2-7 complexRFC Heteropentamer:RNA primer-DNA primerMcm7Orc3Phosphorylated Cdc6ATP1. Assembly of the pre-replicative complexCdt1with the replication forkRFC38RNA primer-DNA primerCdt1Mcm6Mcm3HOMOLOGY MAPPMcm24. Switching of origins to post-replicative stateOrc1RNA PrimerOrc3Mcm4RNA primer-DNA primer:origin duplex:PCNAPCNA homotrimerADPPhosphorylated Orc1Primasep49Orc complexPre-replicative complexaATPCdc6Mcm45. Leading/lagging strand synthesisMcm 4,6,7 trimer forms and associatesMcm7RFC37Degraded by proteasome in cytosolRFC Heteropentamer:RNA primer-DNA primer:RFC140ATPp58Orc3ATPRFC36p180dUTPRFC40Cdt1RNA primer-DNA primerMcm5Cdc6ADPOrc2Orc complex3. DNA replication initiationCdc6CTPOrc complexdCTPMcm3RPA3Mcm7Gnf1RpL40CDK2CDC45LDNApol-alpha73ASKRfC40GMNNdpaMcm5POLD3Mcm10Pole2DNApol-alpha50CG5971POLD4latCG8142mus209DNAprimRfC38l(1)G0148DNApol-epsilonDNApol-deltaDNApol-alpha180Orc6Ubi-p63EOrc4RfC3Orc1CG9273CG12018Orc5Orc2dupMcm2RpA-70RPA4Mcm6


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116917view11:58, 15 May 2021EweitzModified title
77446view20:30, 8 September 2014MaintBot
71551view19:25, 17 October 2013MaintBotAutomated update of data sources
67164view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
62530view13:38, 29 April 2013EgonwConverted many labels into Metabolite DataNodes.
62523view12:47, 29 April 2013EgonwConnected dots.
40888view22:34, 1 March 2011MaintBotRemoved redundant pathway information and comments
35216view15:48, 11 February 2010Thomasadded literature
35212view15:45, 11 February 2010ThomasModified description
35202view15:40, 11 February 2010ThomasModified description
21870view11:32, 14 November 2008MaintBot[[Pathway:Drosophila melanogaster:DNA replication Reactome]] moved to [[Pathway:WP565]]: Moved to stable identifier
8513view14:01, 7 January 2008MaintBotAdded to category $category
19416view14:01, 7 January 2008D.KorenUploaded new pathway
8511view14:01, 7 January 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC45LGeneProduct31052 (Entrez Gene)
CDK2GeneProduct
CG12018GeneProduct38228 (Entrez Gene)
CG5971GeneProduct38989 (Entrez Gene)
CG8142GeneProduct32763 (Entrez Gene)
CG9273GeneProduct35364 (Entrez Gene)
DNApol-alpha180GeneProduct42553 (Entrez Gene)
DNApol-alpha50GeneProduct38942 (Entrez Gene)
DNApol-alpha73GeneProduct43278 (Entrez Gene)
DNApol-deltaGeneProduct39746 (Entrez Gene)
DNApol-epsilonGeneProduct42758 (Entrez Gene)
DNAprimGeneProduct44915 (Entrez Gene)
GMNNGeneProduct
Gnf1GeneProduct40607 (Entrez Gene)
Mcm10GeneProduct35390 (Entrez Gene)
Mcm2GeneProduct40973 (Entrez Gene)
Mcm3GeneProduct31449 (Entrez Gene)
Mcm5GeneProduct41296 (Entrez Gene)
Mcm6GeneProduct31603 (Entrez Gene)
Mcm7GeneProduct39014 (Entrez Gene)
Orc1GeneProduct35686 (Entrez Gene)
Orc2GeneProduct41703 (Entrez Gene)
Orc4GeneProduct37970 (Entrez Gene)
Orc5GeneProduct34794 (Entrez Gene)
Orc6GeneProduct36017 (Entrez Gene)
POLD3GeneProduct
POLD4GeneProduct
Pole2GeneProduct38661 (Entrez Gene)
RPA3GeneProduct
RPA4GeneProduct
RfC3GeneProduct34423 (Entrez Gene)
RfC38GeneProduct34550 (Entrez Gene)
RfC40GeneProduct38492 (Entrez Gene)
RpA-70GeneProduct40972 (Entrez Gene)
RpL40GeneProduct33629 (Entrez Gene)
Ubi-p63EGeneProduct38456 (Entrez Gene)
dpaGeneProduct35679 (Entrez Gene)
dupGeneProduct47121 (Entrez Gene)
l(1)G0148GeneProduct31598 (Entrez Gene)
latGeneProduct36454 (Entrez Gene)
mus209GeneProduct37290 (Entrez Gene)

Annotated Interactions

No annotated interactions
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