Cell cycle (Bos taurus)

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1mediated+pS-phase proteinsG2Histone DeacetylasesS+pep27,57(Start)+pDNA damage checkpoint+p+pSecurin+u+pApoptosisGrowth Factor+p+pMR-point+peMCM (Mini-ChromosomeMaintenance) complexproteolysis+uHDACp21G1+u+pSeparinDNA+pTranscription Factor E2Fesignaling+u+ppathway+pUbiquitin-p-p+p+pGrowth Factor withdrawalORC (OriginRecognition complex)DNA biosynthesis+u+pp16,15,18,19DNA+pMAPKCondensineeBUB1BESPL1TP53RB1ORC3LGSK3BSMAD3SMAD4LOC517559CDH1BUB1CCNE2CCNB3E2F6CDC14BHDAC1CDKN1BARFMCMEP300MDM2ORC6LUBE2FHDAC3SCFE2F5CDC25BMCM2CHEK2YWHAGMCM4MPEG1CDC14AMCM6SMC1ACDC6CDC7SCFORC5LMAD2L214-3-3CDKN2ACDK2CCND2ATRCDKN1AHDAC5ORC2LCDK4E2F1PTTG1ORCCHEK1CDC2E2FLOC509843DBF4HDAC6APC/CCCNA1ORC1LE2F2CDC20MAD2L1SKP2CCNA2CCNE1APC/CABL1PKMYT1TGFB1MCM3PCNARB1CCNB2CDC25ASKP2GADD45AORC4LHDAC8CCNB1MAD1L1TBC1D8CCNA2CDK2BUB3CCNA1CCNHPTTG2E2F4RB1E2F3ATMCDK2CDC25CMCM5CDK6CDC45LGeneProductWEE1RBL1PRKDCPTTG3CCND3CDC2PLK1HDAC2RBL1TFDP1MENMCM7


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html
GenMAPP remarks 
Right-click here to see notes
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP179(r30295) with a 79% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD; ''Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.''; Science, 1998 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
120485view09:24, 8 December 2021EgonwMade four pathways clickable
117485view11:00, 21 May 2021EweitzModified title
115732view09:39, 9 March 2021EgonwReplaced the WP id of a human pathways with the matching cow pathway
89450view12:59, 15 September 2016Mkutmonremove space in ontology term id
80905view15:30, 30 June 2015Mkutmonhomology conversion
71398view19:00, 17 October 2013MaintBotAutomated update of data sources
63321view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62702view23:16, 1 May 2013MaintBotUpdated UniProt data source
40502view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35374view09:16, 12 February 2010MartijnVanIerselModified description
33745view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
32533view13:00, 17 August 2009MaintBotFixed text labels
32220view12:46, 15 August 2009MaintBotFixed text labels
31716view11:53, 14 August 2009MaintBotFixed group labels
31231view19:44, 13 August 2009MaintBotFixed text labels
30652view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
14-3-3GeneProduct
ABL1GeneProduct540876 (Entrez Gene) ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
APC/CGeneProduct
ARFGeneProduct
ATMGeneProduct526824 (Entrez Gene) ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
ATRGeneProduct504869 (Entrez Gene) ATR; ataxia telangiectasia and Rad3 related
BUB1GeneProduct514777 (Entrez Gene) BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
BUB1BGeneProduct537027 (Entrez Gene) BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
BUB3GeneProduct539594 (Entrez Gene) BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)
CCNA1GeneProduct521939 (Entrez Gene) CCNA1; cyclin A1
CCNA2GeneProduct281667 (Entrez Gene) CCNA2; cyclin A2
CCNB1GeneProduct327679 (Entrez Gene) CCNB1; cyclin B1
CCNB2GeneProduct281668 (Entrez Gene) CCNB2; cyclin B2
CCNB3GeneProductCCNB3; cyclin B
CCND2GeneProduct615414 (Entrez Gene) CCND2; cyclin D2
CCND3GeneProduct540547 (Entrez Gene) CCND3; cyclin D3
CCNE1GeneProduct533526 (Entrez Gene) CCNE1; cyclin E
CCNE2GeneProduct538436 (Entrez Gene) CCNE2; cyclin E
CCNHGeneProduct615512 (Entrez Gene) CCNH; cyclin H
CDC14AGeneProduct614777 (Entrez Gene) CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
CDC14BGeneProduct520428 (Entrez Gene) CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CDC20GeneProduct515376 (Entrez Gene) CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
CDC2GeneProduct281061 (Entrez Gene) CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
CDC25AGeneProduct520188 (Entrez Gene) CDC25A; cell division cycle 25A [EC:3.1.3.48]
CDC25BGeneProduct505847 (Entrez Gene) CDC25B; cell division cycle 25B [EC:3.1.3.48]
CDC25CGeneProduct507731 (Entrez Gene) CDC25C; cell division cycle 25C [EC:3.1.3.48]
CDC45LGeneProduct507122 (Entrez Gene) CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
CDC6GeneProduct515301 (Entrez Gene) CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
CDC7GeneProduct516094 (Entrez Gene) CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDH1GeneProduct282637 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene) CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
CDK4GeneProduct510618 (Entrez Gene) CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
CDK6GeneProduct511754 (Entrez Gene) CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDKN1AGeneProduct513497 (Entrez Gene)
CDKN1BGeneProduct512613 (Entrez Gene) CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CDKN2AGeneProduct616369 (Entrez Gene)
CHEK1GeneProduct513678 (Entrez Gene) CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CHEK2GeneProduct518897 (Entrez Gene) CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
DBF4GeneProduct510916 (Entrez Gene) ASK; activator of S phase kinas
E2FGeneProduct
E2F1GeneProduct535369 (Entrez Gene) E2F1; E2F transcription factor 1
E2F2GeneProduct617024 (Entrez Gene) E2F2; E2F transcription factor 2
E2F3GeneProduct541184 (Entrez Gene) E2F3; E2F transcription factor 3
E2F4GeneProduct525428 (Entrez Gene) E2F4; E2F transcription factor 4 p107/p130-binding
E2F5GeneProduct539427 (Entrez Gene) E2F5; E2F transcription factor 5 p130-binding
E2F6GeneProduct514085 (Entrez Gene) E2F6; E2F transcription factor 6
EP300GeneProductEP300; E1A binding protein p300
ESPL1GeneProduct506740 (Entrez Gene) ESPL1; extra spindle poles like 1 (S. cerevisiae
GADD45AGeneProduct505463 (Entrez Gene)
GSK3BGeneProduct790875 (Entrez Gene) GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
GeneProductGeneProduct
HDAC1GeneProduct404126 (Entrez Gene) HDAC1; histone deacetylase 1
HDAC2GeneProduct407223 (Entrez Gene) HDAC2; histone deacetylase 2
HDAC3GeneProduct404125 (Entrez Gene) HDAC3; histone deacetylase 3
HDAC5GeneProduct504242 (Entrez Gene) HDAC5; histone deacetylase 5
HDAC6GeneProduct513602 (Entrez Gene) HDAC6; histone deacetylase 6
HDAC8GeneProduct540666 (Entrez Gene) HDAC8; histone deacetylase
LOC509843GeneProduct509843 (Entrez Gene) HDAC7A; histone deacetylase 7
LOC517559GeneProduct517559 (Entrez Gene) HDAC4; histone deacetylase 4
MAD1L1GeneProduct517837 (Entrez Gene) MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
MAD2L1GeneProduct787996 (Entrez Gene) MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2GeneProduct506605 (Entrez Gene) MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
MCMGeneProduct
MCM2GeneProduct510120 (Entrez Gene) MCM2; MCM2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae
MCM3GeneProduct281302 (Entrez Gene) MCM3; MCM3 minichromosome maintenance deficient 3 (S. cerevisiae)
MCM4GeneProduct504367 (Entrez Gene) MCM4; MCM4 minichromosome maintenance deficient 4 (S. cerevisiae
MCM5GeneProduct506970 (Entrez Gene) MCM5; MCM5 minichromosome maintenance deficient 5 cell division cycle 46 (S. cerevisiae)
MCM6GeneProduct517812 (Entrez Gene) MCM6; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog S. pombe) (S. cerevisiae)
MCM7GeneProduct539924 (Entrez Gene) MCM7; MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
MDM2GeneProduct540378 (Entrez Gene) MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
MENGeneProduct
MPEG1GeneProduct539997 (Entrez Gene)
ORCGeneProduct
ORC1LGeneProduct513523 (Entrez Gene) ORC1L; origin recognition complex subunit 1-like (yeast)
ORC2LGeneProduct511281 (Entrez Gene) ORC2L; origin recognition complex subunit 2-like (yeast)
ORC3LGeneProduct523714 (Entrez Gene) ORC3L; origin recognition complex subunit 3-like (yeast)
ORC4LGeneProduct529245 (Entrez Gene) ORC4L; origin recognition complex subunit 4-like (yeast)
ORC5LGeneProduct519409 (Entrez Gene) ORC5L; origin recognition complex subunit 5-like (yeast)
ORC6LGeneProduct515476 (Entrez Gene) ORC6L; origin recognition complex subunit 6-like (yeast)
PCNAGeneProduct515499 (Entrez Gene) PCNA; proliferating cell nuclear antigen
PKMYT1GeneProduct522613 (Entrez Gene) PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
PLK1GeneProduct538238 (Entrez Gene) PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
PRKDCGeneProduct512740 (Entrez Gene) PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
PTTG1GeneProduct539883 (Entrez Gene) PTTG1; pituitary tumor-transforming
PTTG2GeneProductPTTG2; pituitary tumor-transforming
PTTG3GeneProductPTTG3; pituitary tumor-transforming
RB1GeneProduct534712 (Entrez Gene) RB1; retinoblastoma 1 (including osteosarcoma)
RBL1GeneProduct524870 (Entrez Gene) RBL1; retinoblastoma-like 1 (p107)
SCFGeneProduct
SKP2GeneProduct519018 (Entrez Gene) SKP2; S-phase kinase-associated protein 2 (p45
SMAD3GeneProduct515125 (Entrez Gene) MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
SMAD4GeneProduct540248 (Entrez Gene) MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
SMC1AGeneProduct282370 (Entrez Gene) SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
TBC1D8GeneProduct527162 (Entrez Gene)
TFDP1GeneProduct534579 (Entrez Gene) TFDP1; transcription factor Dp-1
TGFB1GeneProduct282089 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
UBE2FGeneProduct617083 (Entrez Gene) UBE2F; ubiquitin-conjugating enzyme E2F (UBC6 homolog C. elegans
WEE1GeneProduct540322 (Entrez Gene) WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
YWHAGGeneProduct286862 (Entrez Gene) YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1083"
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