Irinotecan pathway (Bos taurus)

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1, 2NeutropeniaIntestineDiarrheaModel human liver cell showing blood, bile and intestinal compartments, indicating tissueinvolvment of genes in the irinotecan pathway.Liver CellCES2IrinotecanAPCCES1CES2CYP3A4SN-38GABCC2M4ABCC1NPCUGT1A6CES1CES2ABCC2UGT1A10ABCC1SN-38IrinotecanCYP3A4ABCC2CYP3A4IrinotecanABCC1SN-38BCHESN-38SN-38UGT1A9ABCG2UGT1A6CES1UGT1A1CYP3A4CES1UGT1A1CES2CYP3A4


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP229(r26589) with a 51% conversion rate.

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Bibliography

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  1. Sai K, Kaniwa N, Itoda M, Saito Y, Hasegawa R, Komamura K, Ueno K, Kamakura S, Kitakaze M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Kitamura Y, Kamatani N, Ozawa S, Sawada J; ''Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.''; Pharmacogenetics, 2003 PubMed Europe PMC Scholia
  2. Desai AA, Innocenti F, Ratain MJ; ''UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.''; Pharmacogenetics, 2003 PubMed Europe PMC Scholia
  3. Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, Ratain MJ; ''Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes.''; J Clin Invest, 1998 PubMed Europe PMC Scholia
  4. Gagné JF, Montminy V, Belanger P, Journault K, Gaucher G, Guillemette C; ''Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38).''; Mol Pharmacol, 2002 PubMed Europe PMC Scholia
  5. Mathijssen RH, Marsh S, Karlsson MO, Xie R, Baker SD, Verweij J, Sparreboom A, McLeod HL; ''Irinotecan pathway genotype analysis to predict pharmacokinetics.''; Clin Cancer Res, 2003 PubMed Europe PMC Scholia
  6. Santos A, Zanetta S, Cresteil T, Deroussent A, Pein F, Raymond E, Vernillet L, Risse ML, Boige V, Gouyette A, Vassal G; ''Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans.''; Clin Cancer Res, 2000 PubMed Europe PMC Scholia
  7. Nozawa T, Minami H, Sugiura S, Tsuji A, Tamai I; ''Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.''; Drug Metab Dispos, 2005 PubMed Europe PMC Scholia
  8. Sai K, Kaniwa N, Ozawa S, Sawada JI; ''A new metabolite of irinotecan in which formation is mediated by human hepatic cytochrome P-450 3A4.''; Drug Metab Dispos, 2001 PubMed Europe PMC Scholia
  9. Rajendra R, Gounder MK, Saleem A, Schellens JH, Ross DD, Bates SE, Sinko P, Rubin EH; ''Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin.''; Cancer Res, 2003 PubMed Europe PMC Scholia
  10. Chen ZS, Furukawa T, Sumizawa T, Ono K, Ueda K, Seto K, Akiyama SI; ''ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P.''; Mol Pharmacol, 1999 PubMed Europe PMC Scholia
  11. Morton CL, Wadkins RM, Danks MK, Potter PM; ''The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase.''; Cancer Res, 1999 PubMed Europe PMC Scholia
  12. Jinno H, Saeki M, Saito Y, Tanaka-Kagawa T, Hanioka N, Sai K, Kaniwa N, Ando M, Shirao K, Minami H, Ohtsu A, Yoshida T, Saijo N, Ozawa S, Sawada J; ''Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
  13. Iyer L, Das S, Janisch L, Wen M, Ramírez J, Karrison T, Fleming GF, Vokes EE, Schilsky RL, Ratain MJ; ''UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.''; Pharmacogenomics J, 2002 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128653view22:24, 17 February 2024EweitzEconomize layout
116614view09:43, 9 May 2021EweitzModified description
116613view09:43, 9 May 2021EweitzModified title
101977view20:02, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
93191view15:04, 2 August 2017DeSlAdded ID for SN-38G and added molecular weight for M4 (unknown metabolite)
93190view15:00, 2 August 2017DeSlAdded refrences for 3 genes (ABCC2, UGT1A10, UGT1A9)
93189view14:55, 2 August 2017DeSlChanged CheMBL compound IDs for irinotecan+SN-38 to ChEBI's
80765view15:25, 30 June 2015Mkutmonhomology conversion
68767view16:02, 7 July 2013EgonwAnd changed it another two times.
68766view16:00, 7 July 2013EgonwChanged the PubChem compound ID of irinotecan, following the discussion of WP961 -> http://wikipathways.org/index.php/Thread:PubChem_ID_for_irinotecan_should_be_verified_%281%29.
67407view10:57, 26 June 2013DdiglesOntology Term : 'irinotecan drug pathway' added !
63392view00:04, 10 May 2013MaintBotUpdated to 2013 gpml schema
40565view19:32, 1 March 2011MaintBotRemoved redundant pathway information and comments
35503view13:13, 12 February 2010ThomasModified description
35502view13:12, 12 February 2010Thomasadded literature, removed genmapp comment
33803view00:18, 9 December 2009MaintBotAutomatic update of empty xrefs
32531view12:59, 17 August 2009MaintBotFixed text labels
32218view12:45, 15 August 2009MaintBotFixed text labels
31713view11:53, 14 August 2009MaintBotFixed group labels
31229view19:44, 13 August 2009MaintBotFixed text labels
30649view22:33, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCC1GeneProduct281588 (Entrez Gene)
ABCC2GeneProduct520925 (Entrez Gene)
ABCG2GeneProduct536203 (Entrez Gene)
APCGeneProduct533233 (Entrez Gene)
BCHEGeneProduct534616 (Entrez Gene)
CES1GeneProduct512098 (Entrez Gene)
CES2GeneProduct505928 (Entrez Gene)
CYP3A4GeneProduct282214 (Entrez Gene)
CYP3A4GeneProduct507988 (Entrez Gene)
IrinotecanMetabolite3750 (PubChem)
M4GeneProduct
NPCGeneProduct
SN-38GeneProduct
SN-38GGeneProduct
UGT1A10GeneProduct
UGT1A1GeneProduct751790 (Entrez Gene)
UGT1A6GeneProduct286792 (Entrez Gene)
UGT1A9GeneProduct

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1080"
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