Hedgehog signaling (Homo sapiens)

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1, 2PMExtracellularCYAcetylationERControlEnzyme complexGene SymbolProteolytic cleavageCY->NUInhibitionPhosphorylationGO(Protein-protein interaction)Golgi apparatusDemethylationECPlasma membraneMethylationMitochondrionDRecruitmentLigandEndosomeNucleusEndoplasmic reticulumAccession Number: NetPath 10; cellmap:10DeubiquitinationCytoplasmProteins in a complex interactionMolecular AssociationCY->NUReceptorPM->ENCY->NUGlycosylationActivationDeacetylationUbiquitinationAutophosphorylationMTCY->PMCY->NUCY->NUDPalmitoylationENDMolecule in the pathwayDephosphorylationSumoylationNUPM->ENDesumoylationTranslocationReaction through unknown mechanisms/moleculesHHIPIHHSKIGLI2SMOSAP18GLI1SIN3ASUFUDYRK1APTCH2PTCH2PTCHGLI3SUFUDHHHHIPRAB23PTCHGAS1SMOHSHHSTK36HHIPCREBBPCDC2IHHSUFUPTCHRAB23SHHGLI1CDC2SHHSHHDHHGLI2IGF2DHHPTCHGLI3CCNB1PTCH2CCNB1IHH


Description

No description

Comments

GenMAPP notes 
NetPath:10 ; cellmap:10 - Hedgehog Signaling Pathway

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129703view01:29, 22 May 2024EweitzModified title
128016view16:05, 21 January 2024EweitzRemove rogue elements, economize layout
128015view16:03, 21 January 2024EweitzAlign legend item, standardize case
126306view17:22, 20 April 2023EgonwLicense is CCZero
120579view17:58, 17 December 2021EweitzModified title
117750view12:48, 22 May 2021EweitzModified title
115907view10:42, 20 March 2021EgonwCopied the NetPath paper into the literature list
115906view09:57, 20 March 2021EgonwModified description
111020view14:28, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
107440view07:03, 8 October 2019DeSlModified title
78542view10:30, 7 January 2015MaintBotadded missing graphIds
70092view18:32, 12 July 2013MaintBotupdating to 2013 schema
47979view14:40, 23 April 2012NetPathModified description
45345view20:25, 7 October 2011AlexanderPicoOntology Term : 'Hedgehog signaling pathway' added !
44831view07:39, 6 October 2011Mkutmonconnected some lines
44830view07:38, 6 October 2011Mkutmonconnected some lines
44618view17:44, 22 September 2011KhanspersAdded category
44617view17:43, 22 September 2011KhanspersUpdating content to NetSlim
44115view20:42, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44039view23:26, 22 August 2011KhanspersModified description
44038view23:25, 22 August 2011KhanspersUpdating pathway from NetSlim
41187view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35650view21:41, 12 February 2010KhanspersModified description
35632view19:08, 12 February 2010AndraAdded references
20775view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Hedgehog Netpath 10]] moved to [[Pathway:WP47]]: Moved to stable identifier
14140view14:47, 21 May 2008Andraexercise
8126view13:46, 7 January 2008MaintBot[[Pathway:Human:Hedgehog Netpath 10]] moved to [[Pathway:Homo sapiens:Hedgehog Netpath 10]]: Renaming species
7684view16:09, 18 December 2007MaintBotfixed category names
7235view12:41, 4 November 2007MaintBotAdded categories to GPML
6331view22:17, 22 May 2007A.Pandeygpml file for [[Human:Hedgehog_Netpath_10]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCNB1GeneProduct891 (Entrez Gene)
CDC2GeneProduct983 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
DHHGeneProduct50846 (Entrez Gene)
DYRK1AGeneProduct1859 (Entrez Gene)
GAS1GeneProduct2619 (Entrez Gene)
GLI1GeneProduct2735 (Entrez Gene)
GLI2GeneProduct2736 (Entrez Gene)
GLI3GeneProduct2737 (Entrez Gene)
HHIPGeneProduct64399 (Entrez Gene)
IGF2GeneProduct3481 (Entrez Gene)
IHHGeneProduct3549 (Entrez Gene)
PTCH2GeneProduct8643 (Entrez Gene)
PTCHGeneProduct5727 (Entrez Gene)
RAB23GeneProduct51715 (Entrez Gene)
SAP18GeneProduct10284 (Entrez Gene)
SHHGeneProduct6469 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SKIGeneProduct6497 (Entrez Gene)
SMOGeneProduct6608 (Entrez Gene)
SMOHGeneProduct6608 (Entrez Gene)
STK36GeneProduct27148 (Entrez Gene)
SUFUGeneProduct51684 (Entrez Gene)

Annotated Interactions

No annotated interactions
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