Notch signaling (Homo sapiens)

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NUReceptorPalmitoylationDGene SymbolRecruitmentDemethylationCY->NUCytoplasmLigandExtracellularDeubiquitinationMolecule in the pathwayProteins in a complex interactionPM->NUGolgi apparatusControlEnzyme complexICDNU->CYMTDPM->NUNucleusEndoplasmic reticulumECICDMitochondrionPM->NUCY->NUMethylationCY->NUENDPM->CYCY->NUAcetylationProteolytic CleavageICDDeacetylationIntracellular DomainICDActivationGO->PMAutophosphorylation(Protein-protein interaction)PM->NUDGOMolecular associationGlycosylation-- ICDGO->PMTranslocationGamma secretase complexNU->CYReactioin through unknown mechanisms/moleculesInhibitionDCY->NUICDUbiquitinationEndosomePMAccession Number: NetPath 3; cellmap:3ERNU->CYDesumoylationPhosphorylationDephosphorylationSumoylationPlasma membraneICDCYDLCKJAG2NFKBIAJAG1DLL4FBXW7TLE1DLL4SKP1AJAK2SMAD3MAPK3SMAD4PSENENNOTCH3AKT1SKP2NCSTNJAG1NOTCH1PSEN2SKP1ALFNGMEF2CTP53HES1JAG2RELAPIK3R1NCOR2APH1ANOTCH3NOTCH4WDR12RELASNW1APH1BNOTCH2HES6PIK3R2MAML3JUNNOTCH2PSEN1ASCL1RING1PCAFNCOR1CDK2MFNGEP300GSK3BGATA1CUL1NOTCH1MAML1STAT3NOTCH1POFUT1LEF1RBX1CNTFSKP2JAG2NCOR2NUMBLFHL1NOTCH3NOVMAML2ADAM10NUMBNOTCH1SIN3AHIVEP3SAP30YY1HDAC2NOTCH2NOTCH2HES5FURINNOTCH1MAGEA1DTX1EGFCNTFRDTX1JAG1APPMAPK1CIRITCHEGFRSMAD1DLL1DLL1HDAC1STAT3CNTN1GSK3BADAM17NOTCH4NOTCH1RBPSUHHEY2TCF3EP300HEY1SPENNCOR1DLL1


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129705view01:29, 22 May 2024EweitzModified title
128032view17:10, 21 January 2024EweitzEconomize layout, refine legend
127899view23:01, 10 January 2024Khanspersupdated mtor xref
126223view06:22, 17 April 2023EgonwLicense is CCZero
120637view21:38, 21 December 2021EweitzRefine case
120636view21:34, 21 December 2021EweitzStandardize font
120582view18:12, 17 December 2021EweitzModified title
117806view14:39, 22 May 2021EweitzModified title
115833view20:38, 17 March 2021EgonwCopied the NetPath paper into the bibliography
115831view20:18, 17 March 2021EgonwModified description
108322view20:55, 6 December 2019L DupuisConverted interactions to graphical lines in legend
107434view06:51, 8 October 2019DeSlModified title
105486view05:43, 8 August 2019KhanspersModified description
105469view05:16, 8 August 2019KhanspersModified description
78592view14:51, 7 January 2015MaintBotadded missing graphIds
70097view18:41, 12 July 2013MaintBotupdating to 2013 schema
47972view14:20, 23 April 2012NetPathModified description
45344view20:24, 7 October 2011KhanspersOntology Term : 'Notch signaling pathway' added !
44599view21:06, 21 September 2011KhanspersAdded category
44598view21:04, 21 September 2011KhanspersModified description
44597view21:03, 21 September 2011KhanspersUpdating content to NetSlim
44114view20:40, 24 August 2011KhanspersReverted to version '23:22, 1 March 2011' by Khanspers
44037view23:23, 22 August 2011KhanspersModified description
44036view23:20, 22 August 2011KhanspersUpdating pathway from NetSlim
41109view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
35651view21:42, 12 February 2010KhanspersModified description
20805view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:Delta-Notch NetPath 3]] moved to [[Pathway:WP61]]: Moved to stable identifier
7984view13:46, 7 January 2008MaintBot[[Pathway:Human:Delta-Notch NetPath 3]] moved to [[Pathway:Homo sapiens:Delta-Notch NetPath 3]]: Renaming species
7616view16:04, 18 December 2007MaintBotfixed category names
7212view12:33, 4 November 2007MaintBotAdded categories to GPML
6308view22:17, 22 May 2007A.Pandeygpml file for [[Human:Delta-Notch_NetPath_3]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProduct102 (Entrez Gene)
ADAM17GeneProduct6868 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
APH1AGeneProduct51107 (Entrez Gene)
APH1BGeneProduct83464 (Entrez Gene)
APPGeneProduct351 (Entrez Gene)
ASCL1GeneProduct429 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CIRGeneProduct9541 (Entrez Gene)
CNTFGeneProduct1270 (Entrez Gene)
CNTFRGeneProduct1271 (Entrez Gene)
CNTN1GeneProduct1272 (Entrez Gene)
CUL1GeneProduct8454 (Entrez Gene)
DLL1GeneProduct28514 (Entrez Gene)
DLL4GeneProduct54567 (Entrez Gene)
DTX1GeneProduct1840 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FBXW7GeneProduct55294 (Entrez Gene)
FHL1GeneProduct2273 (Entrez Gene)
FURINGeneProduct5045 (Entrez Gene)
GATA1GeneProduct161882 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HDAC2GeneProduct3066 (Entrez Gene)
HES1GeneProduct3280 (Entrez Gene)
HES5GeneProduct388585 (Entrez Gene)
HES6GeneProduct55502 (Entrez Gene)
HEY1GeneProduct23462 (Entrez Gene)
HEY2GeneProduct23493 (Entrez Gene)
HIVEP3GeneProduct59269 (Entrez Gene)
ITCHGeneProduct83737 (Entrez Gene)
JAG1GeneProduct182 (Entrez Gene)
JAG2GeneProduct3714 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LFNGGeneProduct3955 (Entrez Gene)
MAGEA1GeneProduct4100 (Entrez Gene)
MAML1GeneProduct9794 (Entrez Gene)
MAML2GeneProduct84441 (Entrez Gene)
MAML3GeneProduct55534 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MFNGGeneProduct4242 (Entrez Gene)
NCOR1GeneProduct9611 (Entrez Gene)
NCOR2GeneProduct9612 (Entrez Gene)
NCSTNGeneProduct23385 (Entrez Gene)
NFKBIAGeneProduct4792 (Entrez Gene)
NOTCH1GeneProduct4851 (Entrez Gene)
NOTCH2GeneProduct4853 (Entrez Gene)
NOTCH3GeneProduct4854 (Entrez Gene)
NOTCH4GeneProduct4855 (Entrez Gene)
NOVGeneProduct4856 (Entrez Gene)
NUMBGeneProduct8650 (Entrez Gene)
NUMBLGeneProduct9253 (Entrez Gene)
PCAFGeneProduct8850 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
POFUT1GeneProduct23509 (Entrez Gene)
PSEN1GeneProduct5663 (Entrez Gene)
PSEN2GeneProduct5664 (Entrez Gene)
PSENENGeneProduct55851 (Entrez Gene)
RBPSUHGeneProduct3516 (Entrez Gene)
RBX1GeneProduct9978 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RING1GeneProduct6015 (Entrez Gene)
SAP30GeneProduct8819 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SKP1AGeneProduct6500 (Entrez Gene)
SKP2GeneProduct6502 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SNW1GeneProduct22938 (Entrez Gene)
SPENGeneProduct23013 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TCF3GeneProduct6929 (Entrez Gene)
TLE1GeneProduct7088 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
WDR12GeneProduct55759 (Entrez Gene)
YY1GeneProduct7528 (Entrez Gene)

Annotated Interactions

No annotated interactions
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