p38 Mapk signaling pathway (Mus musculus)

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1-8Growth Factors, UVTrophic Factors, etc.??DNA transcription?Right click for commentsCytokines Production,Apoptosis, etc.FASL, InflammatoryCytokines, UV, etc.TranslationStress: Osmotic shockg-radiation, Anisomycin?Apoptosis?Atf2Pla2g4aRasgrf1Stat1Rps6ka5Ripk1Map2k6Shc1DaxxTraddTgfbr1Map2k4Cdc42Mapkapk5Map3k7Mknk1Mapk14Grb2Ddit3MycTraf2Mapk14Mapkapk2Hras1Hspb1Mapkapk2Map3k5MaxElk1Hmgn1Rac1Tgfb2Creb1Mef2dMap3k1Map3k9


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP400(r21524) with a 94% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  3. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  4. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  5. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  6. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  7. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  8. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
123113view07:03, 4 July 2022EgonwMade a pathway clickable
116726view10:05, 11 May 2021EweitzModified title
116724view10:04, 11 May 2021EweitzModified title
95744view13:50, 19 January 2018MkutmonHomology conversion update
95233view19:17, 26 November 2017DeSlOntology Term : 'cytokine mediated signaling pathway' added !
95211view12:04, 24 November 2017Mkutmonadded homology converter comment source
70038view02:05, 12 July 2013AlexanderPicoModified title
69208view18:25, 8 July 2013MaintBotUpdated to 2013 gpml schema
67570view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
41398view00:30, 2 March 2011MaintBotRemoved redundant pathway information and comments
38354view05:20, 2 September 2010KhanspersPeriodical save, work in progress
38236view21:14, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38235view21:14, 27 August 2010Khanspers
35698view23:07, 12 February 2010KhanspersDescription and Bibliography
33044view21:36, 7 October 2009MaintBotadded xrefs
32405view17:03, 15 August 2009MaintBotFixed text labels
32060view13:33, 14 August 2009MaintBotFixed group labels
31435view21:03, 13 August 2009MaintBotFixed text labels
30871view00:14, 30 July 2009MaintBotConverted from Homo sapiens
21413view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:p38 MAPK signaling pathway]] moved to [[Pathway:WP350]]: Moved to stable identifier
8326view13:46, 7 January 2008MaintBot[[Pathway:Mouse:p38 MAPK signaling pathway]] moved to [[Pathway:Mus musculus:p38 MAPK signaling pathway]]: Renaming species
7781view16:17, 18 December 2007MaintBotfixed category names
7323view12:42, 4 November 2007MaintBotAdded categories to GPML
6512view22:19, 22 May 2007S.Burelgpml file for [[Mouse:p38_MAPK_signaling_pathway]]

External references

DataNodes

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NameTypeDatabase referenceComment
Atf2GeneProduct11909 (Entrez Gene)
Cdc42GeneProduct12540 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
DaxxGeneProduct13163 (Entrez Gene)
Ddit3GeneProduct13198 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Hmgn1GeneProduct15312 (Entrez Gene)
Hras1GeneProduct15461 (Entrez Gene)
Hspb1GeneProduct15507 (Entrez Gene)
Map2k4GeneProduct26398 (Entrez Gene)
Map2k6GeneProduct26399 (Entrez Gene)
Map3k1GeneProduct26401 (Entrez Gene)
Map3k5GeneProduct26408 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Map3k9GeneProduct338372 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
Mapkapk5GeneProduct17165 (Entrez Gene)
MaxGeneProduct17187 (Entrez Gene)
Mef2dGeneProduct17261 (Entrez Gene)
Mknk1GeneProduct17346 (Entrez Gene)
MycGeneProduct17869 (Entrez Gene)
Pla2g4aGeneProduct18783 (Entrez Gene)
Rac1GeneProduct19353 (Entrez Gene)
Rasgrf1GeneProduct19417 (Entrez Gene) PDZ domain containing guanine nucleotide exchange
Ripk1GeneProduct19766 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 1
Rps6ka5GeneProduct73086 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Tgfb2GeneProduct21808 (Entrez Gene)
Tgfbr1GeneProduct21812 (Entrez Gene)
TraddGeneProduct71609 (Entrez Gene)
Traf2GeneProduct22030 (Entrez Gene)

Annotated Interactions

No annotated interactions
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