Energy metabolism (Homo sapiens)

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CYTOPLASM?= Key regulator= PPARGC1A co-activates nuclear receptors and transcription factors= PPARGC1A and muscle controlPPARGC1A P= PPARGC1A induced by external stimuliTranscription Nuclear Encoded GenesPImported to mitochondria= Double positive feedback loop= PPARGC1A induces expressionPCYTOPLASM= PPARGC1A, PPARs and UCP2, 3PNUCLEUSMuscular atrophyPre-initiation ComplexNUCLEUSGenes of mitochondrial fatty acid oxidationenzymesP= family members of PPARGC1A= transcription factors for mtDNAPost-transcriptional modificationPPARGPPARGC1AMEF2APPARGC1AHDAC1PPARGC1ANCOA1MEF2CTFB1MUnknown Transcription FactorsPPARGC1AEP300MYBBP1AUnknown Transcription Factors NRF1PPARGC1ATFAMCREB1PPP3CBATF2GABPAPRKAG1TFB1MFOXO1PPARAPPARGC1ASIRT1Unknown Transcription FactorsPPP3R2PPP3CCPPARGC1APPARGC1AFOXO3PRKAB1GSK3BPPARGC1APRKAG2MEF2BPPARGC1APPARDTFB2MMAPK14MEF2DTFAMAcetylCAMK4PRMT1CAMK2GPPP3R1PPARAFOXO3CAMK4TFB2MPPARGC1BRXRAPRKAA1ESRRAPPARGPPARGC1ATFB2MMED1PPARGC1APRKAG3PPARDTFB1MCREB1PPARGC1APPP3CAUnknown Transcription FactorsPPARGC1APRKAB2PPARGC1APPRC1PPARGC1APPARGC1AUCP2Unknown Transcription FactorsUnknown Transcription FactorsUnknown Transcription FactorsPPARGHDAC1UCP3SIRT3PRKAA2PPARGC1APPARA


Description

The PPARGC1A protein is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with the nuclear receptor PPARG, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Source: Wikipedia (wikipedia:PPARGC1A)

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History

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CompareRevisionActionTimeUserComment
126394view15:26, 26 April 2023EgonwLicense is CCZero
117711view12:27, 22 May 2021EweitzModified title
106404view21:33, 28 August 2019KhanspersModified description
105585view04:43, 10 August 2019KhanspersModified description
94314view12:10, 1 September 2017Marvin M2Connected unconnected line
94237view12:49, 29 August 2017DeSlChanged ID for acetyl (which was an acetyl leaving group), added ID for CAMK4
94202view14:54, 25 August 2017DeSlAdded ID for acetaldehyde
91584view19:53, 18 March 2017AlexanderPicotweaked interactions
91583view19:49, 18 March 2017MaintBotremoving color and legend to enable general use
89375view06:28, 10 September 2016EgonwConnected lines.
80210view21:02, 22 May 2015KhanspersReverted to version '17:36, 8 July 2013' by Khanspers
80182view20:02, 18 May 2015Khanspersremoved node coloring
80167view22:28, 14 May 2015KhanspersAdded mir219 targeting of CAMK2G, removed node colors, added labels, added states
68947view17:36, 8 July 2013MaintBotUpdated to 2013 gpml schema
45242view18:25, 7 October 2011AlexanderPicoOntology Term : 'energy metabolic pathway' added !
41103view23:22, 1 March 2011MaintBotRemoved redundant pathway information and comments
38811view08:31, 24 September 2010Jildaucompartment
38121view01:34, 13 August 2010AlexanderPicofixed legend
38118view01:00, 13 August 2010AlexanderPicoModified categories
38117view00:59, 13 August 2010AlexanderPicoModified description
38116view00:53, 13 August 2010AlexanderPicofinished connecting datanodes and lines
38115view00:23, 13 August 2010AlexanderPicoPeriodical save, work in progress
38094view00:29, 12 August 2010AlexanderPicofixed arrows and datanodes in top third of pathway
38093view23:58, 11 August 2010AlexanderPicoConnecting genes to database, fixing lines and datanodes
38091view23:49, 11 August 2010AlexanderPicoPeriodical save, work in progress
38089view23:38, 11 August 2010AlexanderPicoadded pathway name
38021view14:06, 30 July 2010MXFKoshoPeriodical save, work in progress
38020view13:59, 30 July 2010MXFKoshoSpecify description
37913view09:34, 16 July 2010MXFKoshoSpecify description
37910view02:35, 16 July 2010MXFKoshoSpecify description
37909view02:32, 16 July 2010MXFKoshoSpecify description
37908view02:26, 16 July 2010MXFKoshoPeriodical save, work in progress
37907view02:24, 16 July 2010MXFKosho
37906view02:16, 16 July 2010MXFKoshoPeriodical save, work in progress
37905view02:04, 16 July 2010MXFKoshoSpecify description
37904view01:59, 16 July 2010MXFKoshoSpecify description
37903view01:54, 16 July 2010MXFKoshoPeriodical save, work in progress
37902view01:45, 16 July 2010MXFKoshoSpecify description
37563view17:12, 11 June 2010MXFKoshoSpecify description
37559view13:51, 11 June 2010MXFKoshoSpecify description
37558view13:46, 11 June 2010MXFKoshoSpecify description
37557view13:38, 11 June 2010MXFKoshoPeriodical save, work in progress
37556view12:57, 11 June 2010MXFKoshoPeriodical save, work in progress
37290view21:21, 24 May 2010MXFKoshoSpecify description
37285view19:20, 24 May 2010MXFKoshoPeriodical save, work in progress
37284view19:01, 24 May 2010MXFKoshoSpecify description
37283view18:01, 24 May 2010MXFKoshoSpecify description
37282view15:01, 24 May 2010MXFKoshoPeriodical save, work in progress
37281view14:49, 24 May 2010MXFKoshoSpecify description
37280view10:44, 24 May 2010MXFKoshoSpecify description

External references

DataNodes

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NameTypeDatabase referenceComment
GeneProduct
ATF2GeneProduct1386 (Entrez Gene)
AcetylMetabolite
CAMK2GGeneProduct818 (Entrez Gene)
CAMK4GeneProduct
CAMK4GeneProduct814 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ESRRAGeneProduct2101 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
FOXO3GeneProduct2309 (Entrez Gene)
GABPAGeneProduct2551 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MED1GeneProduct5469 (Entrez Gene)
MEF2AGeneProduct4205 (Entrez Gene)
MEF2BGeneProduct100271849 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MEF2DGeneProduct4209 (Entrez Gene)
MYBBP1AGeneProduct10514 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NRF1GeneProduct4899 (Entrez Gene)
PPARAGeneProduct5465 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PPARGGeneProduct5468 (Entrez Gene)
PPARGC1AGeneProduct
PPARGC1AGeneProduct10891 (Entrez Gene)
PPARGC1BGeneProduct133522 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPRC1GeneProduct23082 (Entrez Gene)
PRKAA1GeneProduct5562 (Entrez Gene)
PRKAA2GeneProduct5563 (Entrez Gene)
PRKAB1GeneProduct5564 (Entrez Gene)
PRKAB2GeneProduct5565 (Entrez Gene)
PRKAG1GeneProduct5571 (Entrez Gene)
PRKAG2GeneProduct51422 (Entrez Gene)
PRKAG3GeneProduct53632 (Entrez Gene)
PRMT1GeneProduct3276 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
SIRT1GeneProduct23411 (Entrez Gene)
SIRT3GeneProduct23410 (Entrez Gene)
TFAMGeneProduct7019 (Entrez Gene)
TFB1MGeneProduct51106 (Entrez Gene)
TFB2MGeneProduct64216 (Entrez Gene)
UCP2GeneProduct7351 (Entrez Gene)
UCP3GeneProduct7352 (Entrez Gene)
Unknown Transcription FactorsGeneProduct
Unknown Transcription Factors GeneProduct

Annotated Interactions

No annotated interactions

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