TP53 network (Homo sapiens)

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43125ApoptosisGrown arrest and apoptosisGrown arrest and apoptosisReduces transcriptional activity but does not induce degradationDifferent isoforms of the proteinPMAIP1IGFBP-3TP73γCDKN1AMYCTAp63αBAXTP73βTP73ζBBC3MDM2CDKN2ATAp63γTP73δTP73 Delta Np73BOKABL1TP63GADD45ASUMO-1TP73αΔNp63αTAp63βATMΔNp63βΔNp63γTP73εTP73TP53


Description

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Shaul Y; ''c-Abl: activation and nuclear targets.''; Cell Death Differ, 2000 PubMed Europe PMC Scholia
  2. Bunt J, de Haas TG, Hasselt NE, Zwijnenburg DA, Koster J, Versteeg R, Kool M; ''Regulation of Cell Cycle Genes and Induction of Senescence by Overexpression of OTX2 in Medulloblastoma Cell Lines.''; Mol Cancer Res, 2010 PubMed Europe PMC Scholia
  3. Ishimoto O, Kawahara C, Enjo K, Obinata M, Nukiwa T, Ikawa S; ''Possible oncogenic potential of DeltaNp73: a newly identified isoform of human p73.''; Cancer Res, 2002 PubMed Europe PMC Scholia
  4. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, Andrews NC, Caput D, McKeon F; ''p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.''; Mol Cell, 1998 PubMed Europe PMC Scholia
  5. Dohn M, Zhang S, Chen X; ''p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes.''; Oncogene, 2001 PubMed Europe PMC Scholia
  6. Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D; ''p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.''; Nature, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134847view19:05, 27 July 2024EweitzEconomize layout
134846view19:02, 27 July 2024EweitzUse gene symbol
134845view18:57, 27 July 2024EweitzClarify isoform-level interactions
134844view18:43, 27 July 2024EweitzClarify interactions visually and computationally
134843view18:30, 27 July 2024EweitzFix typo: "Grown arrest" -> "Growth arrest"
134842view18:28, 27 July 2024EweitzEconomize layout
134841view17:07, 27 July 2024EweitzRefine legend
134840view17:01, 27 July 2024EweitzEconomize layout
126403view19:23, 26 April 2023EgonwLicense is CCZero
116592view16:31, 8 May 2021EweitzModified title
106445view23:35, 28 August 2019KhanspersModified description
105494view05:49, 8 August 2019KhanspersModified description
95548view14:32, 22 December 2017DeSlCOnnected more unconencted lines, changed several lines to graphical lines.
95475view23:43, 17 December 2017AndraConnected lines
95435view05:30, 15 December 2017MaintBotfixed xref
71700view19:51, 17 October 2013MaintBotUpdated data sources
70104view18:54, 12 July 2013MaintBotupdated to 2013 schema
70032view01:57, 12 July 2013AlexanderPicoModified title
59109view22:22, 21 February 2013MaintBotUpdated Ensembl data source
48062view18:41, 1 May 2012KhanspersReplaced special characters
48060view18:14, 1 May 2012KhanspersPeriodical save, work in progress
45074view20:17, 6 October 2011KhanspersOntology Term : 'cancer' added !
45073view20:16, 6 October 2011KhanspersOntology Term : 'p53 signaling pathway' added !
41057view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39274view22:33, 9 November 2010AlexanderPicoModified categories
39273view22:32, 9 November 2010AlexanderPicoconnected line from SUMO-1 to TP53
39272view22:30, 9 November 2010AlexanderPicospecified xref systems, e.g., Entrez, UniProt or Ensembl
39264view11:17, 8 November 2010GlendaPeriodical save, work in progress
39263view10:56, 8 November 2010GlendaPeriodical save, work in progress
39262view10:36, 8 November 2010GlendaPeriodical save, work in progress
39261view09:54, 8 November 2010GlendaPeriodical save, work in progress
39260view09:43, 8 November 2010GlendaPeriodical save, work in progress
39205view07:57, 28 October 2010GlendaPeriodical save, work in progress
39204view07:47, 28 October 2010GlendaPeriodical save, work in progress
39203view07:10, 28 October 2010GlendaModified description
39202view05:03, 28 October 2010GlendaModified description
39197view14:05, 27 October 2010GlendaPeriodical save, work in progress
39196view13:49, 27 October 2010GlendaPeriodical save, work in progress
39195view13:38, 27 October 2010GlendaPeriodical save, work in progress
39194view13:28, 27 October 2010GlendaPeriodical save, work in progress
39193view13:18, 27 October 2010GlendaPeriodical save, work in progress
39192view13:02, 27 October 2010GlendaPeriodical save, work in progress
39191view12:52, 27 October 2010GlendaPeriodical save, work in progress
39190view12:39, 27 October 2010GlendaPeriodical save, work in progress
39189view12:28, 27 October 2010GlendaPeriodical save, work in progress
39188view12:18, 27 October 2010GlendaPeriodical save, work in progress
39187view12:08, 27 October 2010GlendaPeriodical save, work in progress
39186view11:57, 27 October 2010GlendaPeriodical save, work in progress
39185view11:12, 27 October 2010GlendaPeriodical save, work in progress
39184view10:59, 27 October 2010GlendaPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct25
ATMGeneProductENSG00000149311
BAXGeneProduct581 (Entrez Gene)
BBC3GeneProduct27113
BOKGeneProduct666
CDKN1AGeneProductENSG00000124762
CDKN2AGeneProduct1029
GADD45AGeneProduct1647
IGFBP-3GeneProductHs.146732 (UniGene)
MDM2GeneProductENSG00000135679 (Ensembl Human)
MYCGeneProduct4609
PMAIP1GeneProduct5366
SUMO-1Protein7341
TAp63αProteinQ9H3D4
TAp63βProteinQ9H3D4 (Uniprot/TrEMBL)
TAp63γProteinQ9H3D4 (Uniprot/TrEMBL)
TP53GeneProduct7157
TP63GeneProduct8626
TP73 Delta Np73ProteinO15350
TP73GeneProduct7161
TP73αProteinO15350
TP73βProteinO15350
TP73γProteinO15350
TP73δProteinO15350
TP73εProteinO15350
TP73ζProteinO15350
ΔNp63αProteinQ9H3D4
ΔNp63βProteinQ9H3D4 (Uniprot/TrEMBL)
ΔNp63γProteinQ9H3D4

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1742"
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