Proteasome degradation (Bos taurus)

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Activators of20S ComplexBeta subunitsDeubiquitinates proteinsProteins to be DegradedAMP Ubiquitin/E1 ComplexUbiquitin/ProteinAlpha subunitsOxidatively DamagedCytosolic ProteinsDegrades only PeptidesE3/ProteinLid subunitsProteasome 26 S(PA700) (ATP dependent)Unfolds and DegradesIntact ProteinsUbiquitin/E2 ComplexProteasome 20SCatalytic Core (p45)Presentation by MHC class 1p45 ATPase SubunitPSMB3PSMD10HLA-BPSMC6UCHL1_BOVINPSMA6PSMA4PSMD2PSMD11HIST1H2ABIFNGUBBHLA-JPSMB7NEDD4PSMD5RPN1PSMA2HLA-CH2AFXHLA-GPSMD1PSMD7PSMB10PSMC2PSME3PSME2PSMB6UCHL3PSMD13UBE2D2PSMA5UBE2D1PSMC1PSMB1UBA7HLA-HPSMD4PSMD9RPN2UbiquitinPSMD6ATPPSMD8PSMB8PSMC3PSMA7PSMC5PSMA3PSMB2PSMA1HLA-FUBCPSMB5PSMB4UBE2BHLA-APSMD12PSME1PSMD3PSMC5UBA1H2AFZPSMC4HLA-EPSMB9UBE2D3


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 73% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia
  2. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117056view14:22, 16 May 2021EweitzModified title
95794view14:41, 19 January 2018MkutmonHomology conversion update
80771view15:25, 30 June 2015Mkutmonhomology conversion
71416view19:01, 17 October 2013MaintBotAutomated update of data sources
63376view23:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
62706view23:18, 1 May 2013MaintBotUpdated UniProt data source
58822view23:19, 20 February 2013MaintBotUpdated Ensembl and UniProt data source
40548view19:31, 1 March 2011MaintBotRemoved redundant pathway information and comments
33788view00:11, 9 December 2009MaintBotAutomatic update of empty xrefs
32530view12:59, 17 August 2009MaintBotFixed text labels
32217view12:45, 15 August 2009MaintBotFixed text labels
31712view11:52, 14 August 2009MaintBotFixed group labels
31228view19:44, 13 August 2009MaintBotFixed text labels
30648view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPMetabolite
H2AFXGeneProduct531733 (Entrez Gene)
H2AFZGeneProduct287016 (Entrez Gene)
HIST1H2ABGeneProduct
HLA-AGeneProduct782684 (Entrez Gene)
HLA-BGeneProduct
HLA-CGeneProduct
HLA-EGeneProduct
HLA-FGeneProduct
HLA-GGeneProduct
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProduct281237 (Entrez Gene)
NEDD4GeneProduct507781 (Entrez Gene)
PSMA1GeneProduct515503 (Entrez Gene)
PSMA2GeneProduct539141 (Entrez Gene)
PSMA3GeneProduct505176 (Entrez Gene)
PSMA4GeneProduct510423 (Entrez Gene)
PSMA5GeneProduct510155 (Entrez Gene)
PSMA6GeneProduct507213 (Entrez Gene)
PSMA7GeneProduct505050 (Entrez Gene)
PSMB10GeneProduct282328 (Entrez Gene)
PSMB1GeneProduct514237 (Entrez Gene)
PSMB2GeneProduct516919 (Entrez Gene)
PSMB3GeneProduct533874 (Entrez Gene)
PSMB4GeneProduct506203 (Entrez Gene)
PSMB5GeneProduct534640 (Entrez Gene)
PSMB6GeneProduct510069 (Entrez Gene) U13393
PSMB7GeneProduct511207 (Entrez Gene)
PSMB8GeneProduct282013 (Entrez Gene)
PSMB9GeneProduct510593 (Entrez Gene)
PSMC1GeneProduct506238 (Entrez Gene)
PSMC2GeneProduct530186 (Entrez Gene)
PSMC3GeneProduct508448 (Entrez Gene)
PSMC4GeneProduct510029 (Entrez Gene) PRS6 HUMAN
PSMC5GeneProduct282015 (Entrez Gene) PRS6 HUMAN
PSMC6GeneProduct518637 (Entrez Gene)
PSMD10GeneProduct535414 (Entrez Gene)
PSMD11GeneProduct513461 (Entrez Gene)
PSMD12GeneProduct538204 (Entrez Gene)
PSMD13GeneProduct513525 (Entrez Gene)
PSMD1GeneProduct511803 (Entrez Gene)
PSMD2GeneProduct539784 (Entrez Gene)
PSMD3GeneProduct504937 (Entrez Gene)
PSMD4GeneProduct282016 (Entrez Gene)
PSMD5GeneProduct515021 (Entrez Gene)
PSMD6GeneProduct538625 (Entrez Gene)
PSMD7GeneProduct512456 (Entrez Gene)
PSMD8GeneProduct785653 (Entrez Gene)
PSMD9GeneProduct513315 (Entrez Gene)
PSME1GeneProduct510041 (Entrez Gene)
PSME2GeneProduct509857 (Entrez Gene)
PSME3GeneProduct
RPN1GeneProduct507939 (Entrez Gene)
RPN2GeneProduct534231 (Entrez Gene)
UBA1GeneProduct282869 (Entrez Gene)
UBA7GeneProduct497204 (Entrez Gene)
UBBGeneProduct
UBCGeneProduct444874 (Entrez Gene)
UBE2BGeneProduct512207 (Entrez Gene)
UBE2D1GeneProduct535287 (Entrez Gene)
UBE2D2GeneProduct541003 (Entrez Gene)
UBE2D3GeneProduct
UCHL1_BOVINGeneProductENSBTAG00000005078 (Ensembl Cow)
UCHL3GeneProduct520170 (Entrez Gene)
UbiquitinProtein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1079"
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